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Evaluation of acute toxicity of Fe2NiO4 nanoparticle on biochemical parameters in rat liver
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Rashed Golmohammadi1    , Zahra Hooshmandi * 2, Mahbubeh Setorki3 |
1- Dept of Biology, Islamic Azad University, Zanjan Branch, Zanjan, Iran
2- Dept of Biology, Islamic Azad University, Sanandaj Branch, Sanandaj, Iran , zhoushmandi@yahoo.com
3- Dept of Biology, Islamic Azad University, Izeh Branch, Izeh, Iran Abstract |
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Abstract: (4855 Views) |
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Evaluation of acute toxicity of Fe2NiO4 nanoparticle
on biochemical parameters in rat liver
Golmohammadi R1, Hooshmandi Z2*, Setorki M3
(Received: May 2, 2017 Accepted: April 14, 2017)
Abstract
Introduction: Magnetic nanoparticles composed of iron and nickel have broad application in biological and medical sciences. Increased production and application of nanoparticles has raised concern about their negative side effects on human health. Materials & Methods: In the present study, we examined the toxicity of Fe2NiO4 nanoparticle on some biochemical parameters of rat’s liver. In this experimental study, 24 male rats were divided into three groups, including the group receiving Fe2NiO4 nanoparticles at a concentratios of 100 ppm, a group receiving the nanoparticle at a concentration of 200 ppm, and the control group. Then, 2, 7, and 14 days after the intervention, we drew blood samples from the rats and the levels of liver biochemical parameters were determined. Findings:According to the results, during the exposure period, serum albumin level was not significantly different between the groups. In the nanoparticle-treated rats, serum transferrin level showed a significant increase on the seventh day and a significant decline on the 14th day (P<0.05). Exposure of rats to the nanoparticle at the doses of 100 and 200 significantly reduced lactate dehydrogenase level compared to the control group (P<0.05). Alkaline phosphatase levels in the groups exposed to nanoparticles were not significantly different from that in the control group.
Conclusion: Results of this study indicated Fe2NiO4 cause to injury of liver.
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| Keywords: Fe2Nio4, Transferrin, Albumin, Lactate dehydrogenase, Alkaline phosphatase |
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Type of Study: Research |
Received: 2017/04/24 | Accepted: 2017/08/12 | Published: 2018/09/15
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