The Effect of Combined Resistance Training and Spirulina Supplementation on Metabolic and Inflammatory Markers in Older Adults: A Systematic Review

Hooshmand Moghadam, Babak; Gaeini, Abbas Ali

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Volume 33, Issue 5 (11-2025)

Journal of Ilam University of Medical Sciences 2025, 33(5): 119-130

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The Effect of Combined Resistance Training and Spirulina Supplementation on Metabolic and Inflammatory Markers in Older Adults: A Systematic Review

Babak Hooshmand Moghadam ^*¹

, Abbas Ali Gaeini²

1- Dept of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran , b.hooshmand.m@gmail.com
2- Dept of Exercise Physiology, Faculty of Sports and Health Sciences, University of Tehran, Tehran, Iran

Abstract: (34 Views)

Introduction: The objective of this systematic review was to investigate the effects of an association between resistance training and Spirulina supplementation on metabolic and inflammatory profile in older individuals.
Materials & Methods: This study is based on searching the databases of PubMed, Scopus, and Google scholar. The eligible criteria were RCT studies, which assessed the effects of resistance training and Spirulina in combination on glycemia, lipid profiles, blood pressure (BP) and inflammatory factors in older subjects.
Results: The outcomes revealed that Spirulina with resistance training resulted in significant decrease of fasting blood glucose, HbA1c, lipid profile (LDL and Triglyceride) and inflammatory markers (CRP and IL-6). Moreover, this intervention also conferred benefits in terms of reducing blood pressure and enhancing quality of life in older adults. Such effects may be attributed to the regulation of biological pathways, such as increased insulin sensitivity, decline in oxidative stress and attenuation of inflammatory responses by both Spirulina supplementation and resistance training.
Conclusion: Resistance training combined with Spirulina supplementation appears to be an effective non-pharmacological intervention in promoting metabolic health and ameliorating inflammation in older adults. Further studies with larger sample sizes and long-term follow-up would be needed to assess the sustainability of these effects.

Keywords: Resistance Exercise, Spirulina Supplementation, Aging, Metabolic Markers, Inflammatory Biomarkers, Systematic Review

Full-Text [PDF 710 kb] (22 Downloads)

Type of Study: Applicable | Subject: biochemistry and nutrition
Received: 2025/04/29 | Accepted: 2025/09/7 | Published: 2025/11/26

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Hooshmand Moghadam B, Gaeini A A. The Effect of Combined Resistance Training and Spirulina Supplementation on Metabolic and Inflammatory Markers in Older Adults: A Systematic Review. J. Ilam Uni. Med. Sci. 2025; 33 (5) :119-130
URL: http://sjimu.medilam.ac.ir/article-1-8610-en.html

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