Synthesis and designing of nanofibers containing zeolitic nanozymes as a wound dressing

Mohammadpour, Mahnaz; Ghanbari, Hamed; Izadi, Zhila; Rezaee, Hanieh; Derakhshankhah, Hossein

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Volume 33, Issue 4 (9-2025)

Journal of Ilam University of Medical Sciences 2025, 33(4): 57-78

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Synthesis and designing of nanofibers containing zeolitic nanozymes as a wound dressing

Mahnaz Mohammadpour¹

, Hamed Ghanbari²

, Zhila Izadi³

, Hanieh Rezaee⁴

, Hossein Derakhshankhah ^*⁵

1- Dept of chemistry, Faculty of Sciences, Tarbiat Modares University, Tehran, Iran
2- Dept of Organic Chemistry, Faculty of Chemistry, Razi University, Kermanshah, Iran
3- Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
4- Pharmaceutical Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
5- Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran , derakhshankhah.hossein@gmail.com

Abstract: (16 Views)

Introduction: Wound healing is crucial for improving patients' quality of life, especially in conditions like diabetes, burns, and surgical wounds. Fiber-based dressings with antioxidant and antibacterial agents, natural polymers, and zeolite nanoparticles accelerate healing and regeneration. The aim of this study was to design and fabricate nanofiber scaffolds based on polyvinyl alcohol (PVA), chitosan, and tragacanth gum, containing zeolite nanoparticles as wound dressings.
Materials & Methods: MT-type zeolite crystals with molecular dimensions and sizes ranging from approximately 10 to 20 nm were synthesized via a low-temperature hydrothermal method using colloidal precursors, without the need for organic templates. The physical and structural properties of the synthesized nanoparticles, including Fourier-transform infrared spectroscopy (FTIR) analysis, particle size distribution, and surface zeta potential, were characterized. Subsequently, nanofibers based on polyvinyl alcohol (PVA), chitosan (CS), and tragacanth gum (TG), incorporating the zeolite nanoparticles, were fabricated through electrospinning. The nanofibers were thoroughly evaluated for their physicochemical, structural, mechanical, cellular toxicity, antioxidant activity, and antibacterial performance.
Results: The characterization tests demonstrated that the nanofiber wound dressings containing zeolite nanoparticles exhibited superior properties compared to the control group without nanoparticles. These nanofibers showed enhanced performance in terms of morphology, fiber diameter, mechanical strength, swelling ratio, degradation rate, porosity, antioxidant activity, cellular biocompatibility, and antibacterial efficacy.
Conclusion: The results of this study demonstrated that nanofibers composed of polyvinyl alcohol (PVA), chitosan (CS), and tragacanth (TG) possess optimal physical and biological properties, creating a suitable environment to accelerate the wound healing process. The study suggests that the incorporation of EMT-type zeolite nanoparticles in PVA/CS/TG/EMT-ZIF nanofibers can enhance their antioxidant and antibacterial properties, making them promising for biomedical engineering applications.

Keywords: EMT-Type Zeolite, Nanofiber Wounds Dressing, Polyvinyl Alcohol, Tragacanth, Chitosan

Full-Text [PDF 1501 kb] (11 Downloads)

Type of Study: Applicable | Subject: research
Received: 2025/04/28 | Accepted: 2025/08/20 | Published: 2025/09/27

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Mohammadpour M, Ghanbari H, Izadi Z, Rezaee H, Derakhshankhah H. Synthesis and designing of nanofibers containing zeolitic nanozymes as a wound dressing. J. Ilam Uni. Med. Sci. 2025; 33 (4) :57-78
URL: http://sjimu.medilam.ac.ir/article-1-8608-en.html

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