Effects of Eight Weeks of Endurance and Resistance Training on Serum Level of Apoptotic Indicators in Elderly Women

Mortezaei, Parvin; Arshadi, Sajad; Banaeifar , Abdolali; Izadi , Mojtaba

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Volume 33, Issue 3 (7-2025)

Journal of Ilam University of Medical Sciences 2025, 33(3): 97-112

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Effects of Eight Weeks of Endurance and Resistance Training on Serum Level of Apoptotic Indicators in Elderly Women

Parvin Mortezaei¹

, Sajad Arshadi ^*²

, Abdolali Banaeifar¹

, Mojtaba Izadi³

1- Dept of Exercise Physiology, South Tehran Branch, Islamic Azad University, Tehran, Iran
2- Dept of Exercise Physiology, South Tehran Branch, Islamic Azad University, Tehran, Iran , Arshadi.sajad@yahoo.com
3- Dept of Exercise Physiology, Saveh Branch, Islamic Azad University, Tehran. Iran

Abstract: (21 Views)

Introduction: The elderly's increased apoptosis causes physical function decline and quality of life loss, requiring non-pharmacological apoptosis regulation techniques. The present study was aimed at examining the effects of eight weeks of endurance and resistance training on apoptotic markers in elderly women.
Materials & Methods: A study involving 39 women over 60 years old was conducted to measure their fitness levels. The participants were divided into three groups: endurance training, resistance training, and control. The endurance training involved walking on a treadmill at 40-70% of maximum heart rate, while the resistance training involved movements with body weight and light dumbbells at 40-70% of one repetition maximum. The exercises were performed in three 20-35-minute sessions per week for eight weeks. Blood samples were collected before and after the intervention, and serum BAX and BCL2 levels were measured using ELISA. SPSS V.21, Shapiro-Wilk test, two-way mixed analysis of variance, and Bonferroni post hoc test were employed for statistical analysis (p<0.05).
Results: Both endurance and resistance training resulted in significant decreases in serum levels of the proapoptotic protein BAX and the BAX/BCL2 ratio, as well as significant increases in the antiapoptotic protein BCL2 (P < 0.05). A comparison between the two training groups showed that resistance training produced a greater decrease in BAX, while endurance training produced a greater increase in BCL2. This difference in protein response between the two training types was statistically significant (P = 0.026).
Conclusion: Regular physical activity, particularly endurance and resistance training, may be an effective non-pharmacological strategy for enhancing cellular health and modulating apoptotic processes in older adults.

Keywords: Resistance training, Endurance training, Apoptosis, Aging

Full-Text [PDF 972 kb] (4 Downloads)

Type of Study: Research | Subject: Physical Education
Received: 2025/02/27 | Accepted: 2025/06/17 | Published: 2025/07/27

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Mortezaei P, Arshadi S, Banaeifar A, Izadi M. Effects of Eight Weeks of Endurance and Resistance Training on Serum Level of Apoptotic Indicators in Elderly Women. J. Ilam Uni. Med. Sci. 2025; 33 (3) :97-112
URL: http://sjimu.medilam.ac.ir/article-1-8561-en.html

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