Investigating the effect of cinnamon supplementation on menstrual cycle bleeding duration and body mass index in women with polycystic ovary syndrome: A single-blind randomized controlled clinical trial study

Behroozi-Lak, Tahereh; Zibarzani, Kheyronnesa

[Home ] [Archive]

[ فارسی ]

Journal of Ilam University of Medical Sciences

Main Menu

Home

Journal Information

Articles archive

Publication Ethics

Peer Review Process

Indexing Databases

For Authors

For Reviewers

Subscription

Contact us

Site Facilities

Google Scholar Metrics

	All	Since 2020
Citations	7121	3691
h-index	28	19
i10-index	203	78

Search in website

Receive site information

Registered in

Volume 33, Issue 2 (5-2025)

Journal of Ilam University of Medical Sciences 2025, 33(2): 115-127

Back to browse issues page

Investigating the effect of cinnamon supplementation on menstrual cycle bleeding duration and body mass index in women with polycystic ovary syndrome: A single-blind randomized controlled clinical trial study

Tahereh Behroozi-Lak ^*¹

, Kheyronnesa Zibarzani²

1- Reproductive Health Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran , T.behrooz2@yahoo.com
2- Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

Abstract: (224 Views)

Introduction: Polycystic ovary syndrome is one of the most common hormonal disorders among women. Cinnamon has shown beneficial effects in reducing the symptoms of the syndrome due to its anti-inflammatory compounds and insulin sensitivity-enhancing properties. The present study aimed to investigate the effect of this supplement on the duration of menstrual bleeding and body mass index in women with polycystic ovary syndrome.
Materials & Methods: A study at Urmia University of Medical Sciences involved 26 women with polycystic ovary syndrome who participated in a six-month intervention. Participants were divided into two groups: those taking cinnamon capsules daily and those taking medroxyprogesterone capsules daily. Body mass index and menstrual cycle bleeding duration were measured before, during, and after the intervention. Data analysis included SPSS V.21, independent t-tests, and ANOVA analysis to compare changes in body mass index.
Results: A significant increase in bleeding duration was observed in the second trimester in the intervention group, but there were no significant between-group changes for this index. There was a significant decrease in body mass index in the cinnamon group at the end of six months, but no significant changes were observed in the between-group comparison.
Conclusion: Changes in bleeding time and body mass index were not significant in the between-group comparison. Further studies with higher doses and larger sample sizes are recommended, along with evaluation of influential variables, including insulin resistance index.

Keywords: Cinnamon, Polycystic Ovary Syndrome, Menstrual Cycle, Body Mass Index

Full-Text [PDF 801 kb] (62 Downloads)

Type of Study: Research | Subject: obstetrics and gynecology
Received: 2024/11/15 | Accepted: 2025/03/3 | Published: 2025/05/26

References

1. Lizneva D, Suturina L, Walker W, Brakta S, Gavrilova-Jordan L, Azziz R. Criteria, prevalence, and phenotypes of polycystic ovary syndrome. Fertil Steril. 2016;106:6-15. doi: 10.1016/j.fertnstert.2016.05.003.

2. Wolf WM, Wattick RA, Kinkade ON, Olfert MD. Geographical prevalence of polycystic ovary syndrome as determined by region and race/ethnicity. Int J Environ Res Public Health. 2018;15:1-13. doi: 10.3390/ijerph15112589.

3. Witchel SF, Oberfield SE, Peña AS. Polycystic ovary syndrome: pathophysiology, presentation, and treatment with emphasis on adolescent girls. J Endocr Soc. 2019;3:1545-73. doi: 10.1210/js.2019-00078.

4. Saei Ghare Naz M, Ramezani Tehrani F. Effect of cinnamon on polycystic ovary syndrome (PCOS): A Systematic Review. Iran J Obst Gynecol Infert. 2021;23:86-97. doi: 10.22038/ijogi.2021.17831.

5. Fauser BC, Tarlatzis BC, Rebar RW, Legro RS, Balen AH, Lobo R, et al. Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group. Fertil Steril. 2012;97:28-38. doi: 10.1016/j.fertnstert.2011.09.024.

6. Salari N, Nankali A, Ghanbari A, Jafarpour S, Ghasemi H, Dokaneheifard S, et al. Global prevalence of polycystic ovary syndrome in women worldwide: a comprehensive systematic review and meta-analysis. Arch Gynecol Obstet. 2024:1-12. doi: 10.1007/s00404-024-07607-x. Epub 2024 Jun 26.

7. Farhadi-Azar M, Behboudi-Gandevani S, Rahmati M, Mahboobifard F, Khalili Pouya E, Ramezani Tehrani F, et al. The prevalence of polycystic ovary syndrome, its phenotypes and cardio-metabolic features in a community sample of Iranian population: Tehran lipid and glucose study. Front Endocrinol (Lausanne). 2022;13:1-11. doi: 10.3389/fendo.2022.825528.

8. ESHRE TR, Group A-SPCW. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81:19-25 doi: 10.1016/j.fertnstert.2003.10.004.

9. Ozcan Dag Z, Alpua M, Isik Y, Buturak SV, Tulmac OB, Turkel Y. The evaluation of temperament and quality of life in patients with polycystic ovary syndrome. Gynecol Endocrinol. 2017;33:250-3. doi: 10.1080/09513590.2016.1254610.

10. Dou L, Zheng Y, Li L, Gui X, Chen Y, Yu M, et al. The effect of cinnamon on polycystic ovary syndrome in a mouse model. Reprod Biol Endocrinol. 2018;16:1-10. doi: 10.1186/s12958-018-0418-y.

11. Rodgers RJ, Avery JC, Moore VM, Davies MJ, Azziz R, Stener-Victorin E, et al. Complex diseases and co-morbidities: polycystic ovary syndrome and type 2 diabetes mellitus. Endocr Connect. 2019;8:R71-R5. doi: 10.1530/EC-18-0502.

12. Sam S. Obesity and polycystic ovary syndrome. Obes Manag. 2007;3:69-73. doi: 10.1089/obe.2007.0019.

13. Celik O, Acbay O. Effects of metformin plus rosuvastatin on hyperandrogenism in polycystic ovary syndrome patients with hyperlipidemia and impaired glucose tolerance. J Endocrinol Invest. 2012;35:905-10. doi: 10.3275/8371. Epub 2012 Apr 18.

14. Norman RJ, Dewailly D, Legro RS, Hickey TE. Polycystic ovary syndrome. Lancet. 2007;370:685-97. doi: 10.1016/S0140-6736(07)61345-2.

15. Arentz S, Smith CA, Abbott J, Fahey P, Cheema BS, Bensoussan A. Combined lifestyle and herbal medicine in overweight women with polycystic ovary syndrome (PCOS): a randomized controlled trial. Phytother Res. 2017;31:1330-40. doi: 10.1002/ptr.5858. Epub 2017 Jul 7.

16. Escobar-Morreale HF. Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol. 2018;14:270-84. doi: 10.1038/nrendo.2018.24.

17. Moini Jazani A, Nasimi Doost Azgomi H, Nasimi Doost Azgomi A, Nasimi Doost Azgomi R. A comprehensive review of clinical studies with herbal medicine on polycystic ovary syndrome (PCOS). Daru. 2019;27:863-77. doi: 10.1007/s40199-019-00312-0.

18. Pundir J, Charles D, Sabatini L, Hiam D, Jitpiriyaroj S, Teede H, et al. Overview of systematic reviews of non-pharmacological interventions in women with polycystic ovary syndrome. Hum Reprod Update. 2019;25:243-56. doi: 10.1093/humupd/dmy045.

19. Günalan E, Yaba A, Yılmaz B. The effect of nutrient supplementation in the management of polycystic ovary syndrome-associated metabolic dysfunctions: A critical review. J Turk Ger Gynecol Assoc. 2018;19:220-32. doi: 10.4274/jtgga.2018.0077.

20. Hosseinkhani A, Asadi N, Pasalar M, Zarshenas MM. Traditional Persian medicine and management of metabolic dysfunction in polycystic ovary syndrome. J Tradit Complement Med. 2018;8:17-23. doi: 10.1016/j.jtcme.2017.04.006.

21. Lunny CA, Fraser SN. The use of complementary and alternative medicines among a sample of Canadian menopausal-aged women. J Midwifery Womens Health. 2010;55:335-43. doi: 10.1016/j.jmwh.2009.10.015.

22. Barnes PM, Bloom B, Nahin RL. Complementary and alternative medicine use among adults and children: United States, 2007. Natl Health Stat Report. 2008;10:1-23.

23. Hadi A, Moradi S, Ghavami A, Khalesi S, Kafeshani M. Effect of probiotics and synbiotics on selected anthropometric and biochemical measures in women with polycystic ovary syndrome: a systematic review and meta-analysis. Eur J Clin Nutr. 2020;74:543-7. doi: 10.1038/s41430-019-0434-9.

24. Hajimonfarednejad M, Nimrouzi M, Heydari M, Zarshenas MM, Raee MJ, Jahromi BN. Insulin resistance improvement by cinnamon powder in polycystic ovary syndrome: A randomized double‐blind placebo controlled clinical trial. Phytother Res. 2018;32 :276-83. doi: 10.1002/ptr.5970.

25. Rao P, Gan S. Cinnamon: a multifaceted medicinal plant. Evid Based Complement Alternat Med. 2014 ;2014:642942. doi: 10.1155/2014/642942.

26. Ainehchi N, Khaki A, Farshbaf-Khalili A, Hammadeh M, Ouladsahebmadarek E. The effectiveness of herbal mixture supplements with and without clomiphene citrate in comparison to clomiphene citrate on serum antioxidants and glycemic biomarkers in women with polycystic ovary syndrome willing to be pregnant: a randomized clinical trial. Biomolecules. 2019;9:215. doi: 10.3390/biom9060215.

27. Akhavan Amjadi M, Mojab F, Shagbazzadegan S. Efficacy of cinnamomum zeylanicum on primary dysmenorrhea and systemic symptom of it on the students of Gilan university of medical sciences 2007. J Ardabil Univ Med Sci. 2009;9(3):204-9.

28. Parseh S, Shakerian S, Alizadeh AA. Effect of Chronic Aerobic/Resistive exercises with supplementation of cinnamon on insulin resistance in women with polycystic ovary syndrome in Ahvaz City in 2017. Journal of Arak University of Medical Sciences. 2019; 9 : 204-9.

29. Kort DH, Lobo RA. Preliminary evidence that cinnamon improves menstrual cyclicity in women with polycystic ovary syndrome: a randomized controlled trial. Am J Obstet Gynecol. 2014;211:1-6. doi: 10.1016/j.ajog.2014.05.009.

30. Azmoudeh BE, Habibian M, Askari B. The Effectiveness of the Combination of Cinnamon and Ginger with Exercise Training in the Treatment of Dysmenorrhea and Premenstrual Syndrome. Iran J Nurs. 2019;32:68-81. doi:10.29252/ijn.32.121.68.

31. Salehpour S, Parsay S, Onsouri S, Setavand S. Comparison of cinnamon extract o metformin effect upon nsulin resistance, apoliporporotein B/apolipoproein A1 ratio and body mass index of obese adolsent girls with polycystic ovary syndrome: a double blind placebo controlde trial. ESPE Abstracts, 54th Annual ESPE. 2015;84:P2-347.

32. Heydarpour F, Hemati N, Hadi A, Moradi S, Mohammadi E, Farzaei MH. Effects of cinnamon on controlling metabolic parameters of polycystic ovary syndrome: A systematic review and meta-analysis. J Ethnopharmacol. 2020;254:1-9. doi: 10.1016/j.jep.2020.112741.

33. Peivandi S, Heydari-Latibari S, Ghasemzadeh F, Zamaniyan M, Bahar A, Majidi H, et al. Metabolic and endocrine changes induced by cinnamon in women with polycystic ovarian syndrome: A pilot study. Avicenna J Phytomed. 2024;14:242-51. doi: 10.22038/AJP.2023.23357.

34. Namazi N, Khodamoradi K, Khamechi SP, Heshmati J, Ayati MH, Larijani B. The impact of cinnamon on anthropometric indices and glycemic status in patients with type 2 diabetes: A systematic review and meta-analysis of clinical trials. Complement Ther Med. 2019;43:92-101. doi: 10.1016/j.ctim.2019.01.002.

35. Dastgheib M, Barati-Boldaji R, Bahrampour N, Taheri R, Borghei M, Amooee S, et al. A comparison of the effects of cinnamon, ginger, and metformin consumption on metabolic health, anthropometric indices, and sexual hormone levels in women with poly cystic ovary syndrome: A randomized double-blinded placebo-controlled clinical trial. Front Nutr. 2022;9:1071515. doi: 10.3389/fnut.2022.1071515.

36. Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP, et al. Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity. J Agric Food Chem. 2004;52:65-70. doi: 10.1021/jf034916b.

37. Wang JG, Anderson RA, Graham III GM, Chu MC, Sauer MV, Guarnaccia MM, et al. The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: a pilot study. Fertil Steril. 2007;88:240-3. doi: 10.1016/j.fertnstert.2006.11.082.

38. Vallianou NG, Evangelopoulos A, Kollas A, Kazazis C. Hypoglycemic and hypolipidemic effects of cinnamon. Curr Top Nutraceuticals Res. 2014;12:1-9.

39. Mohammad P, Zienab B, Hossein KJ. The Effect of cinnamon extract on gonadotrop in changes (FSH& LH) in rats treated with gelophen. Biomed Pharmacol J. 2015;7:363-7 doi: 10.13005/bpj/499.

Send email to the article author

Add your comments about this article

Ethics code: IR.Umsu.rec.1396.133

Mendeley

Zotero

RefWorks

Behroozi-Lak T, Zibarzani K. Investigating the effect of cinnamon supplementation on menstrual cycle bleeding duration and body mass index in women with polycystic ovary syndrome: A single-blind randomized controlled clinical trial study. J. Ilam Uni. Med. Sci. 2025; 33 (2) :115-127
URL: http://sjimu.medilam.ac.ir/article-1-8447-en.html

Rights and permissions
	This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Volume 33, Issue 2 (5-2025)

Back to browse issues page

Persian site map - English site map - Created in 0.15 seconds with 41 queries by YEKTAWEB 4701