Examining changes in serum levels of Irisin and Brain-Derived Neurotrophic Factor in inactive middle-aged men in two phases of training and detraining

Afahar, Rezvan; Rahmati, Masoud; Mirnasuri, Rahim

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Volume 33, Issue 3 (7-2025)

Journal of Ilam University of Medical Sciences 2025, 33(3): 14-26

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Examining changes in serum levels of Irisin and Brain-Derived Neurotrophic Factor in inactive middle-aged men in two phases of training and detraining

Rezvan Afahar¹

, Masoud Rahmati ^*²

, Rahim Mirnasuri¹

1- Dept of Physical Education and Sports Sciences, Faculty of Literature and Humanities, Lorestan University, Khorramabad, Iran
2- Dept of Physical Education and Sports Sciences, Faculty of Literature and Humanities, Lorestan University, Khorramabad, Iran , rahmati.mas@lu.ac.ir

Abstract: (30 Views)

Introduction: Resistance training increases irisin and brain-derived neurotrophic factor secretion, impacting myogenic regulatory factors and muscle function, but maintaining these adaptations remains a challenging challenge. Accordingly, the present study was designed to investigate changes in serum irisin and brain-derived neurotrophic factor levels in inactive middle-aged men during two phases of training and detraining.
Materials & Methods: This quasi-experimental study was conducted on middle-aged men with an average age of 39.87±6.05 years. The exercise protocol was performed 3 times a week for 12 weeks, and then 24 weeks of detraining were performed. Irisin and brain-derived neurotrophic factor were measured on 3 occasions before the start of training, at 12 and 36 weeks. Repeated measures ANOVA and independent t-tests were used in SPSS V.27 with significance set at p≤0.05.
Results: Serum levels of Irisin, brain-derived neurotrophic factor, and muscle strength increased significantly after 12 weeks in the training group compared to the control group (p=0.001). However, 24 weeks of detraining led to a significant decrease in irisin and muscle strength to baseline levels, and no difference was observed between the training and control groups (p=0.001). While despite the significant decrease of brain-derived neurotrophic factor in the training group following detraining (p=0.001), the level of brain-derived neurotrophic factor in the training group remained higher than the control group (p=0.052), and a significant difference between the training group and control was observed (p=0.001).
Conclusion: Resistance training can improve muscle strength and increase irisin and brain-derived neurotrophic factor secretion in middle-aged people.

Keywords: Detraining, Irisin, Brain-Derived Neurotrophic Factor, Resistance training

Full-Text [PDF 888 kb] (3 Downloads)

Type of Study: Research | Subject: Physical Education
Received: 2024/10/23 | Accepted: 2025/03/11 | Published: 2025/07/27

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Afahar R, Rahmati M, Mirnasuri R. Examining changes in serum levels of Irisin and Brain-Derived Neurotrophic Factor in inactive middle-aged men in two phases of training and detraining. J. Ilam Uni. Med. Sci. 2025; 33 (3) :14-26
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