Theoretical, Instrumental, and Cytotoxic Evaluation of Synthetic Zinc Ferrite Nanoparticles for their Use in Targeted Drug Delivery to Target Tissue: Nano-Biophysical Chemistry Approach

Safari, Reza; Hadi, Hamid; Nazemi, Maryam

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Volume 30, Issue 5 (12-2022)

Journal of Ilam University of Medical Sciences 2022, 30(5): 51-67

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Theoretical, Instrumental, and Cytotoxic Evaluation of Synthetic Zinc Ferrite Nanoparticles for their Use in Targeted Drug Delivery to Target Tissue: Nano-Biophysical Chemistry Approach

Reza Safari ^*

¹, Hamid Hadi²

, Maryam Nazemi³

1- Dept of Chemistry, Faculty of Basic Sciences, University of Qom, Qom, Iran , R.SAFARI@QOM.AC.IR
2- Dept of Chemistry, Faculty of Basic Sciences, Lorestan University, Khoramabad, Iran
3- Dept of Women, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract: (1159 Views)

Introduction: Today, the use of magnetic nanomaterials promises purposeful and intelligent drug delivery. These magnetic drug nanocarriers can respond appropriately and intelligently to the external magnetic field, which can be used to selectively release the drug into the target tissue. Therefore, this study investigated the synthesis of zinc ferrite nanoparticles and some of their structural, electronic, and magnetic properties. The ultimate goal of this study is to use nanotechnology and quantum mechanics in intelligent and targeted drug delivery to improve the patient's quality of life and reduce the destructive effects of unwanted drug distribution in healthy tissues.
Material & Methods: In this study, zinc ferrite nanoparticles were prepared using heat treatment, and then the structural and magnetic properties of these nanoparticles were investigated using imaging-measurement methods on the nanoscale. In addition, cytotoxicity test (MTT) was performed on mouse fibroblast cell line (NIH3T3), and the results were analyzed using SPSS software. Moreover, using the results of quantum calculations, the chitosan molecular system was proposed as a coating for this drug carrier.
Findings: Analysis of the results obtained from X-ray diffraction (XRD) and electron microscopy (SEM) spectra confirmed the existence of spinel structure and the small size of these particles (20-23 nm). Furthermore, the results obtained from the vibrating magnetometer and the paramagnetic resonance spectrometer showed the presence of paramagnetic properties in the synthetic nanoparticles. In addition, the analysis of the results obtained from the vibrating magnetometer shows the low magnetic residue of the synthetic magnetic nanoparticles. This can be useful in the mechanism of targeted drug release. In addition, analysis of cytotoxicity (MTT) test results on synthetic nanoparticles showed that the toxicity of these nanoparticles depends on the concentration (dose) and time. Therefore, at concentrations higher than 20 µg/ml and also over time, the vital activity of cells decreased.
Discussion & Conclusion: Based on the results obtained in this study, the use of magnetic zinc ferrite nanoparticles (coated with chitosan) for targeted drug delivery to the target tissue was suggested. The unique properties of these drug-carrying nanoparticles, such as good magnetic field response, good particle size, and low toxicity, enable the physician to have more precise control over targeted drug delivery to the target tissue.

Keywords: Targeted drug delivery - Drug release - Magnetic nanoparticles - Magnetic field - Superparamagnetic - Zinc ferrite - Chitosan - X-ray diffraction (XRD) - Electron microscopy (SEM) - Vibrating magnetometer (VSM)

Full-Text [PDF 2187 kb] (542 Downloads)

Type of Study: Research | Subject: biophysics
Received: 2020/12/29 | Accepted: 2022/04/10 | Published: 2022/12/6

References

1. Kadyrzhanov K, Egizbek K, KozlovskiyA, Zdorovets M. Synthesis and Properties of Ferrite-Based Nanoparticles. Nanomaterials 2019; 9: 1079. doi: 10.3390/nano9081079.

2. Reck M, Mellemgaard A, Novello S, Postmus PE , Gaschler-Markefski B, Kaiser R , et al. Change in non-small-cell lung cancer tumor size in patients treated with nintedanib plus docetaxel: analyses from the Phase III LUME-Lung 1 study. Onco Targets Ther 2018; 11:4573-82. doi: 10.2147/OTT.S170722.

3. Naoyo N, Hirohisa Y, Takashi N, Toshiharu K, Masamichi K. Angiogenesis in Cancer. Vasc Health Risk Manag. 2006; 2: 213-19. doi: 10.2147/vhrm.2006.2.3.213

4. Manshadi M, Saadat M, Mohammadi M, Shamsi M, Dejam M, KamaliR,Sanati-Nezhad A. Delivery of magnetic micro/nanoparticles and magnetic-based drug/cargo into arterial flow for targeted therapy. Drug Deliv 2018; 25: 1963–73. doi: 10.1080/10717544.2018.1497106.

5. Safari R, Hadi H. Use of Dextran-Coated Cobalt-Zinc Ferrite Nanoparticles to Improve Image Quality in Magnetic Resonance Imaging: Non-Clinical Approach. Russian J Phys Chem 2021; 95: 99-108. doi:10.1134/S0036024421130203.

6. Sònia T , Satoshi H, Christian K, Oriol N, Marie H, Johan B, et al. Genetic deficiency in plasma protein HRG enhances tumor growth and metastasis by exacerbating immune escape and vessel abnormalization. Cancer Res 2012; 72: 1953-63. doi:10.1158/0008-5472.CAN-11-2194.

7. Silvia C, Faridah Y, Wan W, Nadzri l, Mohammad O. An overview of drug delivery vehicles for cancer treatment: Nanocarriers and nanoparticles including photovoltaic nano-particles. J Photochem Photobiol B 2016; 164: 151-59. doi: 10.1016/j.jphotobiol.2016.09.013.

8. Zhao Z, Ukidve A, Kim J, Mitragotri S. Targeting Strategies for Tissue-Specific Drug Delivery. Cell 2020; 181: 151-67. doi: 10.1016/j.cell.2020.02.001.

9. Ebrahimi M, Raeisi Shahraki R, Seyyed Ebrahimi SA. Magnetic Properties of Zinc Ferrite Nanoparticles Synthesized by Coprecipitation Method. J Supercond Nov Magn 2014; 27, 1587-92. doi:10.1007/s10948-014-2485-4.

10. Yadollahpour A. Magnetic Nanoparticles in Medicine: A Review of Synthesis Methods and Important Characteristics. Orient J Chem 2015; 31: 271-77. doi:10.13005/ojc/31.

11. Ebrahimi M, RaeisiShahraki R, Ebrahimi S, Masoudpanah S. Magnetic Properties of Zinc Ferrite Nanoparticles Synthesized by Copre-cipitation Method. J Supercond Nov Mag 2014; 27: 1587-92. doi:10.1007/s10948-014-2485-4.

12. Goodarznaseri M, Saion E, Hashim M, Abbastabar H. Synthesis and characterization of zinc ferrite nanoparticles by a thermal treatment method. Solid State Commun 2011; 151:1031-35. doi:10.1016/j.ssc.2011.04.018.

13. Thirupathi G , Singh R . Magnetic Properties of Zinc Ferrite Nanoparticles. IEEE Trans Mag 2012; 48: 3630 - 33. doi: 10.1109/TMAG.2012.2199475.

14. Stuart C, Humphrey H, Jon D. Magnetic nanoparticles for gene and drug delivery. Int J Nanomedicine 2008; 3: 169-80. doi: 10.2147/ijn.s1608.

15. Sutapa B, Samir M. Challenges associated with Penetration of Nanoparticles across Cell and Tissue Barriers: A Review of Current Status and Future Prospects. Nano Today 2014; 9: 223-43. doi: 10.1016/j.nantod.2014.04.008.

16. Hadi H, Safari R, Shamlouei H R. Impact of calcination temperature on the spin-spin relaxation time (T2) of MgFe2O4 nanoparticles (In-vitro). Canadian J Chem 2022. doi: 10.1139/cjc-2022-0105.

17. Simon DA, Vanessa VG, Christopher DG. Magnetic Functionalized Nanoparticles for Biomedical, Drug Delivery and Imaging Applications. Nanoscale Res Lett 2019;14:188. doi: 10.1186/s11671-019-3019-6.

18. Hadi H, Safari R, Shamlouei H R. Synthesis and experimental/theoretical evaluation of β-CD/MTX nanostructure for use in targeted drug delivery systems. Chem Pap 2022. doi:10.1007/s11696-022-02459-8.

19. Ranjita S, Nanosuspensions: a new approach for organ and cellular targeting in infectious diseases. J Pharm Investig 2013; 43: 1-26. doi:10.1007/s40005-013-0051-x.

20. Youqing S, Huadong T, Maciej R, Edward V, William J. pH-responsive nanoparticles for cancer drug delivery. Methods Mol Biol 2008; 437:183-216. doi: 10.1007/978-1-59745-210-6-10.

21. Daniel H, Matthias K, Annette M, Emmanuel K, Philipp B, Sabrina D. Directing the orientational alignment of anisotropic magnetic nanoparticles using dynamic magnetic fields. Faraday Discuss 2015; 181: 449-61. doi: 10.1039/C4FD00242C.

22. Kumar C, Mohammad F. Magnetic Nanomaterials for Hyperthermia-based Therapy and Controlled Drug Delivery. Adv Drug Deliv Rev 2011; 63: 789-808. doi: 10.1016/j.addr.2011.03.008.

23. Arruebo M, Fernández-Pacheco R, Ibarra M, Santamaría J. Magnetic nanoparticles for drug delivery. Int J Nanotoday 2007; 2: 22-32. doi:10.1016/S1748-0132(07)70084-1.

24. Weiwei G, Juliana C, Omid arokhzad F. pH-responsive Nanoparticles for Drug Delivery. Mol Pharm 2010; 7: 1913-20. doi:10.1021/mp100253e.

25. Moghanizadeh A, Ashrafizadeh F, Varshosaz J. Study the effect of static magnetic field intensity on drug delivery by magnetic nanoparticles. Sci Rep 2021; 11: 18056. doi:10.1038/s41598-021-97499-7.

26. Jessica F, Bian J, David I, Andrew T. Use of Magnetic Fields and Nanoparticles to Trigger Drug Release and Improve Tumor Targeting. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2019; 11: e1571. doi: 10.1002/wnan.1571. Epub 2019 Jun 26.

27. Slavko K, Tanja P, Petra K, Silvia M, Darko M. Design and Fabrication of Magnetically Responsive Nanocarriers for Drug Delivery. Curr Med Chem 2017; 24:454-69. doi: 10.2174/ 0929867323666160813211736.

28. Malathi L, Amsaveni R, Anitha N, Balachander N. Reticuloendothelial malignancy of head and neck: A comprehensive review. J Pharm Bioallied Sci 2015; 7: S145–S157. doi: 10.4103/0975-7406.155867.

29. Schleicher C, Baas JC, Elser H, Senninger N. Reticuloendothelial system blockade promotes progression from mild to severe acute pancreatitis in the opossum. Ann Surg 2001;233(4):528-36. doi: 10.1097/00000658-200104000-00008.

30. Kianfar E. Magnetic Nanoparticles in Targeted Drug Delivery: A Review. J Supercond Nov Mag 2021; 34: 1709-35. doi:10.1007/s10948-021-05932-9.

31. Kravanja G, Primožič M, Knez Z, Leitgeb M. Chitosan-based (Nano)materials for Novel Biomedical Applications. Molecules 2019; 24: 1960. doi: 10.3390/molecules24101960.

32. Umbreen H, Sagun P, Hui K, Andrew M S. Antibody Drug Conjugates for Cancer Therapy. Molecules 2020; 25: 4764. doi: 10.3390/ molecules25204764.

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Safari R, Hadi H, Nazemi M. Theoretical, Instrumental, and Cytotoxic Evaluation of Synthetic Zinc Ferrite Nanoparticles for their Use in Targeted Drug Delivery to Target Tissue: Nano-Biophysical Chemistry Approach. J. Ilam Uni. Med. Sci. 2022; 30 (5) :51-67
URL: http://sjimu.medilam.ac.ir/article-1-6927-en.html

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