[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 27, Issue 2 (6-2019) ::
sjimu 2019, 27(2): 169-178 Back to browse issues page
Involvement of Dorsal Hippocampal Muscarinic Cholinergic Receptors of CA1 Area on Anxiety Induced by Iron Oxide Nanoparticles in Adult Male Rats
Lotfollah Khajehpour1 , Azam Karimi 2, Mahnaz Kesmati1 , Mozhgan Torabi1
1- Dept of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran
2- Dept of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran , a-karimi-6813@yahoo.com
Abstract:   (314 Views)
Introduction: Recent findings revealed the biological effects of iron oxide nanoparticles on the central nervous system. Moreover, the brain cholinergic system plays a role in the modulation of anxiety behaviors. Therefore, this study aimed to evaluate the role of dorsal hippocampal muscarinic cholinergic receptors of the CA1 area on anxiety induced by iron oxide nanoparticles in adult male rats.
 
Materials & Methods: This experimental study was conducted on adult male Wistar rats with a weight range of 200-250 g. All animals were cannulated in the CA1 area using stereotactic surgery. One week after the recovery the intracerebroventricular injection followed by intraperitoneal (IP) injection after 5 min were administered. Anxiety-like behavior and locomotor activity were performed by elevated plus maze apparatus one week after the injections. The groups were divided into control (saline), iron oxide nanoparticle (5, 7.5 mg/kg,IP), pilocarpine (1,2 µg/rat, intra-hippocampal injection), pilocarpine (1µg/rat, intra-hippocampal injection)+iron oxide nanoparticle (7.5mg/kg, IP) ,and pilocarpine (2µg/rat, intra-hippocampal injection)+iron oxide nanoparticle (7.5mg/kg, IP). Ethics code: EE/96.24.3.88369/SCU.AC.IR
 
Findings: Iron oxide nanoparticles (7.5 mg/kg) increased the anxiety level, compared to the control group (P<0.05). However, pilocarpine injection (1μg/rat) before iron oxide nanoparticles (7.5 mg/kg) improved the anxiety induced by iron oxide nanoparticle (P<0.05).
 
Discussion &Conclusions: It seems that probably the anxiogenic effect of iron oxide nanoparticles is mediated through the reduction of dorsal hippocampal muscarinic cholinergic receptor functions in CA1area.
 
Keywords: Anxiety, Hippocampus, Iron oxide nanoparticle, Muscarinic receptors, Rat
Full-Text [PDF 772 kb]   (96 Downloads)    
Type of Study: Research | Subject: animal physiology
Received: 2018/05/29 | Accepted: 2018/10/16
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Khajehpour L, Karimi A, Kesmati M, Torabi M. Involvement of Dorsal Hippocampal Muscarinic Cholinergic Receptors of CA1 Area on Anxiety Induced by Iron Oxide Nanoparticles in Adult Male Rats . sjimu. 2019; 27 (2) :169-178
URL: http://sjimu.medilam.ac.ir/article-1-5001-en.html


Volume 27, Issue 2 (6-2019) Back to browse issues page
مجله علمی پزوهشی دانشگاه علوم پزشکی ایلام scientific journal of ilam university of medical sciences
Persian site map - English site map - Created in 0.21 seconds with 33 queries by YEKTAWEB 3986