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:: Volume 25, Issue 1 (5-2017) ::
sjimu 2017, 25(1): 211-219 Back to browse issues page
The Effects of Ginger Supplementation on Cardiovascular Risk Factors in Patients with Non-alcoholic Fatty Liver Disease: A Randomised, Double-blind, Placebo-controlled Study
Mehran Rahimlou1, Hoda Ahmadnia2, Azita Hekmatdoost3, Moayed Alavian Seyed4, Ali Keshavarz Seyed 5
1- Dept of nutrition science,Faculty of Nutrition and Dietetic, Tehran University of Medical Sciences,Tehran, Iran
2- Shiraz University of Medical Science
3- Depat of Clinical Nutrition, Faculty of Nutrition and Dietetic, Shahid Beheshti University of Medical Sciences,Tehran, Iran
4- Gastroenterology and Hepatology Research Center of Baqiyatallah Hospital,Tehran, Iran
5- Dept of nutrition science,Faculty of Nutrition and Dietetic, Tehran University of Medical Sciences,Tehran, Iran , s_akeshavarz@yahoo.com
Abstract:   (4556 Views)

Introduction: Nonalcoholic fatty liver is a very common chronic liver disease that is caused by some factors such as insulin resistance, central obesity, type 2 diabetes mellitus and dyslipidemia. The beneficial effects of ginger on metabolic disorders have been shown previously. The aim of this study was to investigate the effect of ginger supplementation on cardiovascular risk factors in patients with non-alcoholic fatty liver disease.

Materials & methods: In this randomized controlled clinical trial study, 50 patients with non-alcoholic fatty liver disease participated in the intervention and placebo groups. For 12 weeks the intervention and placebo groups received 2 gram of ginger or placebo, respectively.  Both groups were advised to follow a balanced diet and physical activity recommendations. Levels of inflammatory biomarkers, lipid profile, fasting blood glucose, insulin and insulin resistance were measured at the beginning and end of the study.

Findings: Ginger supplementation reduced inflammatory biomarkers, fasting blood glucose, insulin resistance and triglyceride levels more than placebo, but there were no significant changes in total cholesterol, HDL and LDL in each group.

Discussion & conclusions: Ginger supplementation reduced levels of some cardiovascular risk factors in patients with non-alcoholic fatty liver disease.

Keywords: Non-alcoholic fatty liver, Cardiovascular diseases, Ginger, Inflammatory biomarkers, Insulin resistance
Full-Text [PDF 783 kb]   (1275 Downloads)    
Type of Study: Research |
Received: 2015/09/19 | Accepted: 2015/12/5 | Published: 2017/05/22
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Rahimlou M, ahmadnia H, hekmatdoost A, alavian M, keshavarz A. The Effects of Ginger Supplementation on Cardiovascular Risk Factors in Patients with Non-alcoholic Fatty Liver Disease: A Randomised, Double-blind, Placebo-controlled Study. sjimu. 2017; 25 (1) :211-219
URL: http://sjimu.medilam.ac.ir/article-1-3063-en.html


Volume 25, Issue 1 (5-2017) Back to browse issues page
مجله علمی پزوهشی دانشگاه علوم پزشکی ایلام scientific journal of ilam university of medical sciences
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