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:: Volume 25, Issue 6 (3-2018) ::
sjimu 2018, 25(6): 199-208 Back to browse issues page
Investigating the Anti-Angiogenesis Effects of Zinc oxide Nanoparticles (ZnO) Synthesized from Aspergillus fungus using Green Method
Mansoureh Amiri 1, Faride Namvar 2, Ali Esahaghi 2, Parichehreh Yaghmaei 1
1- dept of biology, faculty of basic sciences, islamic azad university, tehran branch, tehran, iran
2- . dept of biology, faculty of basic sciences, islamic azad university, mashhad branch , mashhad, iran
Abstract:   (246 Views)

Introduction: Angiogenesis is a complex process. In fact, it is one of the most important biological events that can be observed with the production of new vessels in many stages of embryonic development and pathological conditions. In pathological conditions such as tumor growth, the progression of the disease is associated with angiogenesis. Therefore, in the present study, the effects of various doses of zinc oxide nanoparticles on chick chorioallantoic membrane (CAM) were assessed.
 
Materials & Methods: In this experimental study, 40 ROSS egg were randomly divided into four groups (controls-group 1-group 2-group 3). After the second day of incubation, a window was opened on the eggs and on the eighth day a gelatin sponge was placed on the chick chorioallantoic membrane. Experimental groups were treated with 500, 1000 and 2000 μg / ml zinc oxide nanoparticles, respectively. On the twelfth day after the incubation, samples were removed from the device and after removing the windows, all of them were viewed using a photo stereomicroscope.
 
Findings: The results showed that zinc oxide nanoparticles significantly reduced the number and length of blood vessels compared to the control sample (P <0.05). The mean length of blood vessels treated with nanoparticles of zinc oxide compared to the control group showed that there was a difference between the treated group with concentration of 500 μg / ml zinc oxide nanoparticle (3.16 ± 0.4 cm) with control group (4.13 ± 0.44 cm) at the level of P < 0.05 is significant.
 
Discussion & Conclusion: The results of this study showed that zinc oxide nanoparticles have anti- angiogenesis activity in an in vivo environment. In vivo studies showed that treatment with this nanoparticle inhibited angiogenesis would reduce the number and length of chick chorioallantoic membrane vein.

Keywords: Angiogenesis, Chick chorioallantoic membrane, Zinc oxide
Full-Text [PDF 670 kb]   (76 Downloads)    
Type of Study: Research | Subject: biochemistry
Received: 2015/08/10 | Accepted: 2016/01/5 | Published: 2018/03/14
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Amiri M, Namvar F, Esahaghi A, Yaghmaei P. Investigating the Anti-Angiogenesis Effects of Zinc oxide Nanoparticles (ZnO) Synthesized from Aspergillus fungus using Green Method. sjimu. 2018; 25 (6) :199-208
URL: http://sjimu.medilam.ac.ir/article-1-2963-en.html


Volume 25, Issue 6 (3-2018) Back to browse issues page
مجله علمی پزوهشی دانشگاه علوم پزشکی ایلام scientific journal of ilam university of medical sciences
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