:: Volume 32, Issue 1 (4-2024) ::
Journal of Ilam University of Medical Sciences 2024, 32(1): 58-65 Back to browse issues page
Serological study of the frequency of human herpesvirus-8 in patients with liver cirrhosis
Ava Hashempour1 , Zahra Musavi1 , Javad Moayedi * 2
1- HIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran
2- HIV/AIDS Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran , cbrc@sums.ac.ir
Abstract:   (211 Views)
Introduction:  Various factors, including viruses, are involved in developing liver cirrhosis. Although the association of human herpesvirus-8 (HHV-8) with liver cirrhosis remains poorly understood, a significant increase in the titer of antibodies against this virus has been observed in cirrhotic patients. The present study aimed to evaluate the frequency of HHV-8-immunoglobulin G (HHV-8 IgG) in Iranian patients with liver cirrhosis.
Material & Methods: In this cross-sectional study, 30 healthy blood donors and 30 patients with liver cirrhosis related to hepatitis B (n=20) and hepatitis C (n=10) viruses from those waiting for liver transplantation were included. The serum seropositivity of HHV-8 IgG antibody was evaluated using the enzyme-linked immunosorbent assay (ELISA) technique.
Results: The seropositivity of HHV-8 IgG antibodies in patients and healthy groups was 6.7% (2 patients) and 3.3% (1 case), respectively, which did not show a significant difference between the two groups (P=0.554). In addition, the infection was not significantly related to the age and gender of the patients (P>0.05).
Discussion & Conclusion: Considering the low prevalence of HHV-8 infection in Iranian patients with liver cirrhosis, it can be concluded that HHV-8 may not be associated with the incidence and progression of liver cirrhosis. Therefore, HHV-8 monitoring will not raise the concern about the development or worsening of liver disorders.
Keywords: CMV infection, Kidney transplantation, Rejection
Full-Text [PDF 390 kb]   (127 Downloads)    
Type of Study: Research | Subject: gastrointestinal and hepatic
Received: 2023/10/16 | Accepted: 2023/12/11 | Published: 2024/05/4
References
1. Rohner E, Wyss N, Trelle S, Mbulaiteye SM, Egger M, Novak U, et al. HHV-8 seroprevalence: a global view. Syst Rev 2014; 3:11-18. doi: 10.1186/2046-4053-3-11.
2. Tseng KC, Lin MN, Chu TY, Tsai JP, Su CC. Predictors of seropositivity for human herpesvirus type 8 in patients with mild cirrhosis. Emerg Microbes Infect 2017;6: e45. doi: 10.1038/emi.2017.32.
3. Noaimi AA, Hameedi AD, Abdullah MM, Ibrahim GA, Hassan HG. Association of Human Herpesvirus Type 8 (HHV-8) expression in patients with Kaposi’s sarcoma: A clinico-immunohistochemical study. J Pak Assoc Dermatol 2023; 33:1446-53.
4. Balada E, Ramentol M, Felip L, Ordi-Ros J, Selva-O'Callaghan A, Simeon-Aznar CP, et al. Prevalence of HHV-8 in systemic autoimmune diseases. J Clin Virol 2015; 62:84-88. doi: 10.1016/j.jcv.2014.11.022.
5. Zhang T, He N, Ding Y, Crabtree K, Minhas V, Wood C. Prevalence of human herpesvirus 8 and hepatitis C virus in a rural community with a high risk for blood-borne infections in central China. Clin Microbiol Infect 2011; 17:395-401. doi: 10.1111/j.1469-0691.2010. 03287.x.
6. Zghair AN, Kasim SF, Mohammed NS, Sharma AK. Seroprevalence and Biomarkers Detection of Human Herpes Virus (HHV-8) in Patients with Kaposi Sarcoma. J Tech 2023; 5:141-46. doi: 10.51173/jt. v5i2.857.
7. Jalilvand S, Shoja Z, Mokhtari-Azad T, Nategh R, Gharehbaghian A. Seroprevalence of Human herpesvirus 8 (HHV-8) and incidence of Kaposi's sarcoma in Iran. Infect Agent Cancer 2011; 6:1-6. doi: 10.1186/1750-9378-6-5.
8. Gras J, Helary M, Carette D, Minier M, Salmona M, Gabassi A, et al. Prevalence, Risk Factors, and Shedding of Human Herpes Virus-8 Among Men Having Sex with Men Enrolled in a Pre-Exposure Prophylaxis Study. Clin Infect Dis 2023; 502:1-7. doi: 10.1093/cid/ciad502.
9. Tung YC, Ke LY, Tsai SM, Lu PL, Tsai WC. High seroprevalence of human herpesvirus 8 infection in patients with systemic lupus erythematosus. Int J Rheum Dis 2013; 16:709-14. doi: 10.1111/1756-185X.12193.
10. Atamna A, Yahav D, Hirzel C. Prevention of Oncogenic Gammaherpesvirinae (EBV and HHV8) Associated Disease in Solid Organ Transplant Recipients. Transpl Int 2023; 36:1-12. doi: 10.3389/ti.2023.11856.
11. Ferrarese A, Zanetto A, Gambato M, Bortoluzzi I, Nadal E, Germani G, et al. Liver transplantation for viral hepatitis in 2015. World J Gastroenterol 2016; 22:1570-80. doi: 10.3748/wjg. v22.i4.1570.
12. Welker MW, Zeuzem S. Pre-and post-transplant antiviral therapy (HBV, HCV). Visc Med 2016; 32:105-09. doi: 10.1159/000445152.
13. Alborzi A, Hashempour T, Moayedi J, Musavi Z, Pouladfar G, Merat S. Role of serum level and genetic variation of IL-28B in interferon responsiveness and advanced liver disease in chronic hepatitis C patients. Med Microbiol Immunol 2017; 206:165-74. doi: 10.1007/s00430-017-0497-y.
14. Hashempoor T, Alborzi AM, Moayedi J, Ajorloo M, Bamdad T, Sharifi AH, et al. A Decline in Anti-Core+ 1 Antibody Titer Occurs in Successful Treatment of Patients Infected with Hepatitis C Virus. Jundishapur J Microbiol 2018;11: e58294. doi: 10.5812/jjm.58294.
15. Chou A, Huang W, Lin M, Su C. Human herpesvirus type 8 in patients with cirrhosis independent of thrombocytopenia. J Clin Pathol 2010; 63:254-58. doi: 10.1136/jcp.2009.071621.
16. Martini S, Tandoi F, Romagnoli R, Rizzetto M. Liver transplantation in hepatitis B/hepatitis D (delta) virus coinfected recipients. Transplantation 2022; 106:1935-39. doi: 10.1097/TP.0000000000004138.
17. Mahmud S, Akbarzadeh V, Abu-Raddad LJ. The epidemiology of hepatitis C virus in Iran: Systematic review and meta-analyses. Sci Rep 2018; 8:150. doi: 10.1038/s41598-017-18296-9.
18. Merat S, Malekzadeh R, Rezvan H, Khatibian M. Hepatitis B in Iran. Arch Iran Med 2000; 3:192-201.
19. Sarvari J, Mansouri M, Hashempoor T, Hosseini SY, Moattari A, Pirbonyeh N, et al. Association of genotype and haplotype of IL-28B Gene with Hepatitis C infection outcome in iran: Spontaneous clearance versus chronic infection. Hepat Mon 2017;17: e45745. doi: 10.5812/hepatmon.45745.
20. Salehi-Vaziri M, Sadeghi F, Almasi Hashiani A, Gholami Fesharaki M, Alavian SM. Hepatitis B Virus Infection in the General Population of Iran: An Updated Systematic Review and Meta-Analysis. Hepat Mon 2016;16: e35577. doi: 10.5812/hepatmon.35577.
21. Hladik W, Dollard SC, Mermin J, Fowlkes AL, Downing R, Amin MM, et al. Transmission of human herpesvirus 8 by blood transfusion. N Engl J Med 2006; 355:1331-38. doi: 10.1056/NEJMoa055009.
22. Zavitsanou A, Sypsa V, Petrodaskalaki M, Kalapothaki V, Whitby D, Hatzakis A. Human herpesvirus 8 (HHV‐8) infection in healthy urban employees from Greece: Seroprevalence and associated factors. J Med Virol 2007; 79:591-96. doi: 10.1002/jmv.20812.
23. Chou AL, Huang WW, Tsao SM, Li CT, Su CC. Human herpesvirus type 8 in patients with cirrhosis: correlation with sex, alcoholism, hepatitis B virus, disease severity, and thrombocytopenia. Am J Clin Pathol 2008; 130:231-37. doi: 10.1309/4FMBN316N4792UQ4.
24. Su CC, Tseng KC, Lin MN, Hsieh TC, Chu TY. High seroprevalence of human herpesvirus type 8 in patients with hepatocellular carcinoma. Eur J Clin Microbiol Infect Dis 2015; 34:55-62. doi: 10.1007/s10096-014-2206-8.
25. Wang W, Gehris BT, Mai B, Chen L, Hu S, You MJ, et al. HHV8-Negative Effusion-Based lymphoma in a patient with recurrent HCV hepatitis status post liver transplantation. Leuk Lymphoma 2022; 63:3480-83. doi: 10.1080/10428194.2022.2123233.
26. Ozaki Y, Tajiri H, Tanaka-Taya K, Mushiake S, Kimoto A, Yamanishi K, et al. Frequent detection of the human herpesvirus 6-specific genomes in the livers of children with various liver diseases. J Clin Microbiol 2001; 39:2173-77. doi: 10.1128/jcm.39.6.2173-2177.2001.
27. Li JC. Reactivation of human herpesvirus (HHV) 6 as etiology of acute liver injury in drug reaction with eosinophilia and systemic symptoms (dress) syndrome: a case report. Cureus 2022; 14:1-7. doi: 10.7759/cureus.29697.
28. Khademolhosseini F, Malekhosseini S, Salahi H, Nikeghbalian S, Bahador A, Lankarani KB, et al. Outcome and characteristics of patients on the liver transplant waiting list: Shiraz experience. Middle East J Dig Dis 2009; 1:63-67.
29. Cohen GM, Langer AL, Sima H, Chang C, Troy K, Taimur S. Hemophagocytic lymphohistiocytosis due to primary HHV-8 infection in a liver transplant recipient. Transplant Direct 2018; 4:411-14. doi: 10.1097/TXD.0000000000000850.
30. Hashempour A, Moayedi J, Musavi Z, Ghasabi F, Halaji M, Hasanshahi Z, et al. First report of HHV-8 viral load and seroprevalence of major blood-borne viruses in Iranian patients with systemic sclerosis. Mult Scler Relat Disord 2021; 51:102872. doi: 10.1016/j.msard.2021.102872.
31. Light TP, Brun D, Guardado-Calvo P, Pederzoli R, Haouz A, Neipel F, et al. Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling. PLoS Biol 2021;19: e3001392. doi: 10.1371/journal.pbio.3001392.
32. Liu CY, Chen BJ, Chuang SS. Primary effusion lymphoma: a timely review on the association with HIV, HHV8, and EBV. Diagnostics 2022; 12:713-31. doi: 10.3390/diagnostics12030713.
33. Meidani M, Aminzadeh Z, Faghih M, Ahmadi N. Are the preventive services for HHV-8 necessary in HIV positive persons in central zone of Iran? Iran J Pathol 2014; 9:133-37.
34. Gharehbaghian A, Zaghal A, Farhadi Langerudi M, Karimi G. Seroepidemiology of the human Herpesvirus (HHV-8) in the haemodialysis patients’ blood donors and HIV-positive individuals in City of Tehran. J Sch Public Health Inst Public Health Res 2006; 4:57-63.
35. Copeland MMM, Trainor J, Cash WJ, Braniff C. Fatal donor-derived Kaposi sarcoma following liver transplantation. BMJ Case Rep 2021;14: e236061. doi: 10.1136/bcr-2020-236061.

Ethics code: IR.SUMS.REC.1397.772

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