1. Miller JN, Black DW. Bipolar disorder and suicide a review. Curr Psychiatr Rep 2020;22:6. doi. 10.1007/s11920-020-1130-0

2. Scaini G, Rezin GT, Carvalho AF, Streck EL, Berk M, Quevedo J. Mitochondrial dysfunction in bipolar disorder evidence pathophysiology and translational implications. Neurosci Biobehav Rev 2016; 68:694-713. doi. 10.1016/j.neubiorev.2016.06.040

3. Muller JK, Leweke FM. Bipolar disorder clinical overview. Med Monatsschr Pharm 2016; 39:363-9.

4. Amy L, Gabrielle R. Bipolar disorders: a review. Am Fam Phys2012; 85:483.

5. Craddock N, Sklar P. Genetics of bipolar disorder. Lancet. 2013; 381:1654-62. doi. 10.1016/S0140-6736(13)60855-7

6. Jezek P, Holendova B, Garlid KD, Jaburek M. Mitochondrial uncoupling proteins subtle regulators of cellular redox signaling. Antioxid Red Sign 2018 1; 29:667-714. doi. 10.1089/ars.2017.7225

7. Pierelli G, Stanzione R, Forte M, Migliarino S, Perelli M, Volpe M, et al. Uncoupling Protein 2: A Key Player and a Potential Therapeutic Target in Vascular Diseases. Oxid Med Cell Longev 2017; 2017:7348372. doi. 10.1155/2017/7348372

8. Sreedhar A, Zhao Y. Uncoupling protein 2 and metabolic diseases. Mitochondrion 2017; 34:135-40. doi.10.1016/j.mito.2017.03.005

9. Galluzzi L, Blomgren K, Kroemer G. Mitochondrial membrane permeabilization in neuronal injury. Nature Rev Neurosci 2009; 10:481-94. doi.10.1038/nrn2665

10. Andreazza AC, Shao L, Wang JF, Young LT. Mitochondrial complex I activity and oxidative damage to mitochondrial proteins in the prefrontal cortex of patients with bipolar disorder. Arch Gen Psychiatr 2010; 67:360-8. doi. 10.1001/archgenpsychiatry.2010.22

11. Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, et al. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity beta cell dysfunction, and type 2 diabetes. Cell 2001; 105:745-55. doi. 10.1016/s0092-8674(01)00378-6

12. Hashemi M, Rezaei H, Kaykhaei MA, Taheri M. A 45bp insertion/deletion polymorphism of UCP2 gene is associated with metabolic syndrome. J Diabetes Metab Disord. 2014; 13:12. doi. 10.1186/2251-6581-13-12

13. Gigante AD, Andreazza AC, Lafer B, Yatham LN, Beasley CL, Young LT. Decreased mRNA expression of uncoupling protein 2 a mitochondrial proton transporter in post mortem prefrontal cortex from patients with bipolar disorder and schizophrenia. Neurosci Lett 2011; 505:47-51. doi.10.1016/j.neulet.2011.09.064

14. Mwer S, Dykes D, Polesky H. A simple salting out procedure for extracting DNA from human nucleated cells. Nucle Acids Res 1988; 16:1215. doi. 10.1093/nar/16.3.1215

15. Wang X, Axelsson J, Nordfors L, Qureshi AR, Avesani C, Barany P, et al. Changes in fat mass after initiation of maintenance dialysis is influenced by the uncoupling protein 2 exon 8 insertion/deletion polymorphism. Nephrol Dial Transplant 2007; 22:196-202. doi.10.1093/ndt/gfl504

16. Ghaderi A, Kohan L, Anvar Z. [Association of UCP2 45bp ins/del gene polymorphism with idiopathic male infertility]. Sci J Ilam Uni Med Sci 2019; 26:189-95. (Persian)

17. Klaus S, Ost M. Mitochondrial uncoupling and longevity a role for mitokines? Exp Gerontol 2020; 130:110796. doi.10.1016/j.exger.2019.110796

18. Andrews ZB, Diano S, Horvath TL. Mitochondrial uncoupling proteins in the CNS in support of function and survival. Nat Rev Neurosci 2005; 6:829-40. doi. 10.1038/nrn1767

19. Gaudry MJ, Jastroch M. Molecular evolution of uncoupling proteins and implications for brain function. Neurosci Lett 2019; 696:140-5. doi. 10.1016/j.neulet.2018.12.027

20. Sullivan PG, Dube C, Dorenbos K, Steward O, Baram TZ. Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death. Ann Neurol 2003; 53:711-7. doi.10.1016/j.neulet.2018.12.027

21. Sans N, Petralia RS, Wang YX, Blahos J, Hell JW, Wenthold RJ. A developmental change in NMDA receptor-associated proteins at hippocampal synapses. J Neurosci 2000; 20:1260-71. doi.10.1523/JNEUROSCI.20-03-01260.2000

22. Hermes G, Nagy D, Waterson M, Zsarnovszky A, Varela L, Hajos M, et al. Role of mitochondrial uncoupling protein-2 in higher brain functions, neuronal plasticity and network oscillation. Mol Metab 2016; 5:415-21. doi.10.1016/j.molmet.2016.04.002

23. Heise V, Zsoldos E, Suri S, Sexton C, Topiwala A, Filippini N, et al. Uncoupling protein 2 haplotype does not affect human brain structure and function in a sample of community dwelling older adults. PLos One 2017; 12:181392. doi. 10.1371/journal.pone.0181392

24. Kaabi YA, Mansor AS, Alfagih AS, Hakami AM, Summ MA, Mjery YA, et al. Frequency of UCP2 45bp ins del polymorphism in Saudi population from Jazan area and its association with autoimmune hypothyroidism UCP2 45bp ins del frequency in hypothyroidism. Int J Health Sci 2020; 14:11-6.

25. Crispim D, Fagundes NJ, Santos KG, Rheinheimer J, Bouças AP, et al. Polymorphisms of the UCP2 gene are associated with proliferative diabetic retinopathy in patients with diabetes mellitus. Clin Endocrinol 2010; 72:612-9. doi.10.1111/j.1365-2265.2009. 03684.x

26. Ghaderi A, Kohan L, Anvar Z. [Association of UCP2 45bp ins del gene polymorphism with idiopathic Male infertility]. SJIMU 2019; 26:189-95. (Persian)

27. Sigitova E, Fisar Z, Hroudova J, Cikankova T, Raboch J. Biological hypotheses and biomarkers of bipolar disorder. Psychiatr Clin Neurosci 2017; 71:77-103. doi.10.1111/pcn.12476