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The effect of Alhagi maurorum(aerial parts)hydroachoholic extract on acute gentamicin nephrotoxicity in rat
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Fatemeh Yaghubian1   , Javad Cheraghi * 2, Minoo Mahmudi3 |
1- Islamic Azad University of Hamedan
2- Ilam university , J.cheraghi@ilam.ac.ir
3- Islamic Azad University of Hamedanamic Azad University |
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Abstract: (9611 Views) |
| Abstract:
Introduction
Gentamicin is an Aminoglycosid antibiotics that is clinically useful in the treatment of urinary tract infection, but an unwanted side effects on the physiological function of the kidneys can cause harmful effects that effects limits its use. Antioxidant compounds found in medicinal plants are good candidate for protecting against the damaging of gentamicin. In the present study for the first time , the protective effect of hydroalcholic extract of aerial parts Alhajy Mayrorum against gentamicin-induced nephrotoxicity in rats is evaluated.
Materials and methods
28 male wistar rats in the weight range of 300±20g were randomly divided into 4 groups(n=7). All rats received the desired compounds in 8 days. In the last day blood samples were taken and serum concentrations of urea, uric acid, creatinine and BUN were measured.
Findings
Gentamicin caused a significant increases in serum urea, uric acid, creatinine and BUN levels in blood rats under investigation and coadministration of gentamicin+plant extract was adjusted to baseline values.
Discussion and Conclusion
Findings of this study showed that Alhajy Maurorum extract can effectively prevents side effects of the gentamicin on the kidneys. Probably Alhajy Maurorum extract can preventunwanted effects of gentamicin on urinary tract function recommended. |
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| Keywords: Alhagi maurorum, gentamicin, nephrotoxicity |
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Full-Text [PDF 2737 kb]
(3302 Downloads)
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Type of Study: Research |
Subject:
physiology
Received: 2013/05/19 | Accepted: 2014/02/10 | Published: 2014/06/15
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