:: Volume 21, Issue 2 (6-2013) ::
Journal of Ilam University of Medical Sciences 2013, 21(2): 28-36 Back to browse issues page
Comparison of metformin and pioglitazone on hs-CRP levels in patients with Type II diabetes
Amir Ziaee1, Sima Hashemipour1, Samiramis Ghavam2, Amir Javadi1, Ramak Ghavam *3, Ameneh Barikani1, Neda Esmailzadehha1
1- Metabolic Disease Research Center, Qazvin University of Medical Science, Qazvin, Iran
2- Ilam University of Medical Sciences
3- Metabolic Disease Research Center, Qazvin University of Medical Science, Qazvin, Iran , ramak.ghavam@yahoo.com
Abstract:   (26819 Views)
Background: Heart disease, particularly coronary heart disease is a major cause of mortality among patients with diabetes mellitus. High level of hs-CRP is considered as a risk factor for heart diseases. Treatment with pioglitazone in patients with or without type II diabetes decreases serum concentrations of hs-CRP. The purpose of this study was to compare the effects of pioglitazone and metformin on hs-CRP level. Material and methods: A randomized clinical trial was performed on 40 patients with type 2 diabetes and defined inclusion criteria. Patients were divided into two groups receiving metformin and pioglitazone. Blood levels of cholesterol, triglycerides, fasting blood glucose, Alanine transaminase, Aspartat aminotransferase, HbA1C and hs-CRP were measured in all subjects before and after 3 month drug therapy. The average change in each group before and after drug therapy were analyzed by paired T-test, the mean change between groups were compared by T-test. Results: In both groups, hs-CRP level was significantly decreased after drug therapy. The mean change of hs-CRP, HbA1C, cholesterol was significantly higher in metformin treated group. Conclusion: Since the average reduction in the level of hs-CRP, cholesterol and HbA1C in diabetic patients treated with metformin is significantly higher than patients treated with pioglitazone treatment with metformin is recommended to reduce risk of heart disease
Keywords: Diabetes mellitus, Metformin, Pioglitazone, hs-CRP, HbA1C
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Type of Study: Research | Subject: gp
Received: 2012/04/18 | Accepted: 2013/08/6 | Published: 2013/09/1

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Volume 21, Issue 2 (6-2013) Back to browse issues page