:: Volume 19, Issue 4 (1-2012) ::
Journal of Ilam University of Medical Sciences 2012, 19(4): 1-11 Back to browse issues page
Efficacy of Prophylactic Intravenous Dexamethasone in
N Manuchehrian , M Arjomandi , M,H Bakhshaeu * 1, P Hajian , N Alipur , A Farhanchi
1- , Bakhshaei@umsha.ac.ir
Abstract:   (14241 Views)
Abstract Introduction: Post dural puncture headache (PDPH) is an important complication of spinal anesthesia, especially in young parturient women after cesarean section. The usage of glucocorticoids such as dexamethasone is a drug suggested to treat PDPH. The aim of this study was to determine the effect, of intravenous dexamethasone in prevention of PDPH after spinal anesthesia in cesarean section. Materials & Methods: This is a doubleblind randomized clinical trial in which 246 cases of parturients candidated for cesarean section. Patients were divided randomly in 6 equal groups(n=41) according to the number of punctures (1, 2 or > 2 punctures) and administration of 8 mg intravenous dexamethasone. All the patients received spinal anesthesia using 75 mg of 5% lidocaine with a 25G quincke needle. Then, thepatientqs age,history of surgery,previous spinal anesthesia and headache,new onset and duration of PDPH and vital signes of patients were recorded. Finally the obtained data were analyzied by SPSS software. Findings: 44(17.9%) patients out of the 246 ones were affected by headache. 12.2% of patients who had received dexamethasone and 23.6% of patients who had not received it suffered from headache,(p-v= 0.030)/ The frequency of hypotension during surgery in patients who had received dexamethasone and those who had not received it were 63.4% and 76.4%, respectedly, (P-v=0.037). Discussion & Conclusion: Administration of intravenous prophylactic dexamethasone caused a significantly decrease in the incidence of PDPH & intraoperative hypotension.So, we suggest the use of 8mg intravenous dexamethasone in susceptive patients for prevention of PDPH.
Keywords: post dural puncture headache, dexamethasone
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Type of Study: Research | Subject: General
Received: 2012/03/13 | Published: 2012/01/15

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Volume 19, Issue 4 (1-2012) Back to browse issues page