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Investigation of Antiangiogenic Properties of Green ZnO Nanoparticles Synthesized By Root Extract of Persicaria bistorta
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Elham Safavi1    , Masoud Homayouni Tabrizi * 2, Ehsan Karimi1 |
1- Dept of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran
2- Dept of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran , mhomayouni6@gmail.com |
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Abstract: (4642 Views) |
Introduction: Angiogenesis is a dynamic procedure that plays a key role in physiological and pathological conditions such as tumor growth. Today, the green synthesized nanoparticles are applied for cancer treatment due to their anti-angiogenic properties. In the green method, the plant extract is used for metal ions exchange into a nanoparticle as an economic and environmental-friendly procedure. In the present study, the anti-angiogenic effects of green ZnO nanoparticles synthesized by Persicaria bistorta root extract were evaluated.
Materials & Methods : As to investigate the anti-angiogenic effects of green synthesized ZnO nanoparticles, 30 Ross eggs were randomly divided into 6 groups including the control ,laboratory control, and 4 experimental groups treated by 250, 500, 1000, and 2000 μg/ml ZnO nanoparticles. On the day 12 after incubation, the effects of ZnO were assessed. The obtained data was analyzed using the SPSS software and ANOVA statistical test. The P<0.05 was regarded as a significance.
Findings: The obtained data showed that the 1000 and 2000 μg/ml of green synthesized ZnO nanoparticles significantly decreased the number and length of chorioallantoic membrane vascular splits (P<0.001), weight and size and the head to tail length of the chicken’s embryos in comparison to the normal controls (P<0.05).
Discussion & Conclusion: Our results demonstrated that the green ZnO nanoparticles synthesized by aqueous Persicaria bistorta root extract restricted the angiogenesis. |
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| Keywords: angiogenesis, ZnO, Chorioallantoic membrane |
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Full-Text [PDF 1091 kb]
(2411 Downloads)
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Type of Study: Research |
Received: 2017/11/21 | Accepted: 2018/04/3 | Published: 2018/06/15
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