:: Volume 25, Issue 1 (5-2017) ::
Journal of Ilam University of Medical Sciences 2017, 25(1): 1-11 Back to browse issues page
The Effect of a Continuous Training on Necrosis and Apoptosis Changes in the Hippocampus of Diabetic Rats
Nabi Shamsaei * 1, Hadi Abdi2 , Morteza Shamsi3
1- Dept of Physical Education and Sports Science, Faculty of Literature and Humanities, Ilam University, Ilam, Iran , shamsaeinabi@gmail.com
2- Dept of Physical Education, Payame Noor University, Tehran, Iran
3- Dept of Parasitology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran
Abstract:   (7577 Views)

Introduction: Diabetes is associated with different neurological disorders in the nervous system that will eventually lead to cell damage. The previous studies have shown the beneficial effects of exercise on brain damage caused by diabetic neuropathy in animal models. In the present study, the effect of aerobic exercise training on cell death in the hippocampal CA1 area neurons in diabetic male rats was investigated.

Materials & methods: 21 adult male Wistar rats (weighing 260-300 g) were purchased from Tehran Pasteur Institute and were randomly divided into three groups: sham group, diabetic group and diabetic + exercise training group (7 rats per group). Diabetes was induced intraperitoneally streptozotocin (STZ) administration at the dose of 60mg/kg. The diabetes criterion was the blood glucose level higher than 250 mg/dl. One week after induction of diabetes, the rats in exercise training group were trained to run on a treadmill 5 days a week for 4 weeks. Necrotic cell death was detected by Nissl staining and apoptosis was detected by TUNEL staining.

Findings: The results showed that aerobic exercise training significantly reduced the diabetes-induced necrotic cell death (p<0.01) and apoptosis (p<0.05) in the hippocampal CA1 area neurons.

Discussion & conclusions: This study showed that aerobic exercise training has neuroprotective effects against diabetic neuropathy. This neuroprotective mechanism of exercise can be an effective way to reduce cerebral complications of diabetes. 

Keywords: Exercise training, Diabetes, Necrosis, Apoptosis
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Type of Study: Research |
Received: 2015/10/20 | Accepted: 2015/12/26 | Published: 2017/04/22

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