:: Volume 22, Issue 7 (in press 2015) ::
Journal of Ilam University of Medical Sciences 2015, 22(7): 164-174 Back to browse issues page
Cardiopulmonary Exercise Testing (CPET) in Moist Environment, and Its Relation to the Selected Markers of Salivary Oxidative
Abstract:   (8353 Views)
Introduction: Asthma and obesity are asso-ciated with breathing problems. Exercising increases the probability of the production of harmful free radicals by increasing oxidative stress on the other hand, it decreases free radicals by stimulating anti oxidative enzymes. There is insufficient information about the evaluation of cardio – respiratory function…. in asthmatic chi-ldren doing acute exercise in humid env-ironment, and also about its relation to Salivary oxidative and anti-oxidative fact-ors. The purpose of this study was to inves-tigate the effect of aerobic and exhaustive exercises on cardio-respiratory indices, and its relation with selected markers of salivary oxidative stress in asthmatic obese children in comparison with healthy children. Materials & Methods: 10 asthmatic obese children (BMI 25.12 and fat 29.86%), and10 healthy obese children (BMI 26.8 and fat 31.49%) did a progressive and exhaustive exercise in a constant tempera-ture environment 2 ± 22 °C, and humidity 65 ± 5%. Saliva samples were collected to determine the levels of Maloen dialdehyde (MDA) and superoxid dismutase(SOD) in two stages, before and after exercise . During exercise, the steady-state levels of cardio-respiratory parameters, such as VO2 peak, oxygen pulse (OP), ventilation thres-hold (VT), were controlled using K4B2 . Heart rate (HR) was measured by the rate Polar gauge during exercising. Findings: Doing exhaustive exercise caused an insignificant decrease in MDA in asth-matic obese children (P = 0.366), and in healthy obese children (P = 0.127). It also caused an insignificant increase in SOD saliva in asthmatic obese children (P = 0.268), and in healthy obese children (P = 0.092). Ventilation threshold in asthmatic obese children was significantly lower than healthy obese children (P <0.005). There wasn´t any significant difference in cardio-respiratory indices )HR,OP,VO2peak (betw-een asthmatic obese children and healthy obese children. An insignificant negative correlation between MDA levels and cardi-ovascular parameters (HR, VT, OP) and SOD with OP was observed, and there was an insignificant positive correlation betwe-en SOD and HR, VT. Discussion & Conclusion: These results indicate that, although, the mild to moderate asthma is associated with salivary oxidative stress and cardiorespiratory dysfunction in the children of present study, but it just dec-reases the ventilation threshold consi-derably. However, further studies should be performed in order to identify the effect of cardio-respiratory exercise intervention on salivary oxidative stress in asthmatic children.
Keywords: Cardiorespiratory function, Ve-ntilation threshold, Salivary Stress, Exerc-ise-induced Asthma
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Type of Study: Research | Subject: physiology
Received: 2015/03/15 | Accepted: 2015/03/15 | Published: 2015/03/15

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Volume 22, Issue 7 (in press 2015) Back to browse issues page