Introduction: With this mind that the high prevalence of Autistic Spectrum Traits (AST) between pediatrics Depression Disorder and also, simultaneity of mood disorders in individual with high level of Autism spectrum traits, Therefore, this study was conduct to found out the relationships of autistic spectrum traits (Social skill, Attention switching, communication, Attention to details, Imaginary) and Depression disorder among girl students of medical sciences university in Ilam. Material & Methods: The statistical society of current research included all of the girl student of medical sciences university in Ilam. The sample of this study includes 250 students who were chosen by multistage randomly sampling method. The Measures used in this research are as follow: Autism spectrum Quotient (AQ) and Depression scale of SCL-90. The outcomes of questionnaire were précised by multiple regression in Stepwise and Enter style. Findings: The results of multiple regression analysis indicated that 7 percent of depression variance was explained by autistic traits also deficiency in communication and social skills emerged as the strongest predictors of depression in students.