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:: Volume 26, Issue 6 (3-2019) ::
sjimu 2019, 26(6): 183-193 Back to browse issues page
Evaluation of the Effects of Ketorolac on Tolerance and Dependence to Morphine in Male Mice
Mahdieh Anoush 1, Maryam Afroogh Dr2
1- Applied Pharmacology Research Centre, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran , anoushm@zums.ac.ir
2- Dep of Pharmacology and Toxicology, Faculty of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
Abstract:   (795 Views)
Introduction: According to the high prevalence of pathologic and physiologic dependence to morphine as a strong opioid analgesics and tolerance to analgesic effects, it seems inevitable to find solutions to reduce these consequences. Previous studies addressed different types of drugs, such as anti-seizure drugs and anti-psychotics. This study aimed to investigate the effects of ketorolac on tolerance and dependence to the analgesic properties of the chronic use of morphine in male mice.
 
Materials & Methods: In this study, adult male albino mice were divided into 9 groups. In order to investigate the analgesic tolerance, mice received morphine plus ketorolac either on 5 consecutive days or a single dose in the fifth day. The hot plate test was performed and latency times were recorded. For the evaluation of chemical pain, formalin subplantar injection was administered and the pain marks were recorded. Finally, dependence assessment was performed using naloxone hydrochloride injection on the fifth day, and the withdrawal symptoms were recorded.
 
Findings: There was a significant difference (P<0.05) among the single dose of morphine, normal saline (as the negative control group), and chronic morphine administration; with no significant difference between taking a single dose of morphine or ketorolac in the addicted mice. Regarding the dependence, there was a significant difference (P<0.05) between the chronic use of morphine and chronic morphine plus ketorolac administration were reported.
 
Discussion & Conclusions: It can be concluded that ketorolac have an anti-analgesic effect on chemical pain. It reduces tolerance to morphine anti-analgesic effect and it is capable of reducing the withdrawal syndrome symptoms induced by naloxone.

 
Keywords: Morphine, Ketorolac, Tolerance, Dependence
Full-Text [PDF 877 kb]   (210 Downloads)    
Type of Study: Research |
Received: 2018/08/5 | Accepted: 2018/12/23
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Anoush M, Afroogh M. Evaluation of the Effects of Ketorolac on Tolerance and Dependence to Morphine in Male Mice . sjimu. 2019; 26 (6) :183-193
URL: http://sjimu.medilam.ac.ir/article-1-5112-en.html


Volume 26, Issue 6 (3-2019) Back to browse issues page
مجله علمی پزوهشی دانشگاه علوم پزشکی ایلام scientific journal of ilam university of medical sciences
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