:: Volume 25, Issue 2 (7-2017) ::
sjimu 2017, 25(2): 101-114 Back to browse issues page
Protective Effects of Simvastatin against Doxorubicin-Induced Changes in Mice Testicular Tissue
Golamreza Najafi 1, Ali Shalizar Jalali2, Mahla Mohammadi3
1- urmia universityDept of Basic Sciences, Faculty of Veterinary Medicine, UrmiaUniveraity, Urmia, Iran , g.najafi2006@yahoo.com
2- urmia universityDept of Basic Sciences, Faculty of Veterinary Medicine, UrmiaUniveraity, Urmia, Iran
3- Dept of Basic Sciences, Faculty of Veterinary Medicine, UrmiaUniveraity, Urmia, Iran
Abstract:   (3971 Views)

Introduction: Doxorubicin (DOX), a widely used antineoplastic compound, is associated with testicular damage and infertility. This study was carried out to disclose the possible preventive effects of simvastatin (SIM), a lipid lowering agent with antioxidant and anti-inflammatory activities, against testicular morphometric-stereological changes due to DOX treatment in mice.

Materials & methods: Male mice, five weeks old, were randomly divided into four groups of six mice each. The DOX was administered to two groups of mice in 5 equal intraperitoneal injections over a period of 4 weeks (4 mg/kg). One of these groups received 5 equal oral doses of SIM (12 mg/kg) along with DOX. A vehicle-treated control group and a SIM control group were also included. Morphometric measurement was determined using calibrated ocular micrometer.

Findings: Histomorphometrical examinations revealed significant reductions in the seminiferous tubules diameters and their epithelial heights along with an increase in testicular capsule thickness and interstitial space widening in DOX-treated mice. All above-mentioned parameters recovered significantly by SIM co-administration.

Discussion & conclusions: These results indicated that SIM may have a preventive role against morphometric-stereological changes caused by DOX in mouse testis.

Keywords: Doxorubicin, Simvastatin, Testis, Mouse
Full-Text [PDF 823 kb]   (1547 Downloads)    
Type of Study: Research |
Received: 2017/01/9 | Accepted: 2017/04/3 | Published: 2017/07/10



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Volume 25, Issue 2 (7-2017) Back to browse issues page