Introduction: Patellofemoral pain syndrome, cause disturbance in pain and performance. The aim of this study was to compare the effect of core stabilization muscles of the trunk with a quadriceps muscle strengthening on pain and functional disability in patients with Patellofemoral pain syndrome.
 
Materials and methods: Among 43 man patients with Patellofemoral pain syndrome, twenty two men were selected and randomly divided into two groups: experimental group 1 (n=11) and experimental group 2 (n=11) respectively. Group 1 participated in strengthing core stability exercises, while group 2 underwent quadriceps strengthening in the same period. Before and after training, pain and performance assessed using a pain scale and a function questionnaire. Collected data were analyzed by paired t-test and independent t-test.
 
Findings: Both groups showed significant differences between pre and post-intervention conditions regarding the VAS, and WOMAC values (P<0/05). Data comparison between the two groups in pain scale VAS and function scale WOMAC showed significant difference before and after the training period, so the rate of healing in group 1 was higher than that of Group 2.
 
Disussion & conclusions: After exercise, groups showed a reduction in pain and improvement in performance. Core stability trainings can increase pelvise stability and prevent frmur adduction and internal rotation. So the results show that exercise was more effective in group 1 than group 2, so it is recommended to exercise therapists in the treatment of patients with Patellofemoral pain syndrome in addition to strengthening the quadriceps muscles use the core stability trainings.