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:: Volume 25, Issue 4 (11-2017) ::
sjimu 2017, 25(4): 161-170 Back to browse issues page
Investigation of Spinal nerve Ligation Effect on Muscular Neurotrophin-4 Gene Expression in Male Wistar Rats
Mohammad Pourranjbar1, Samaneh Mehri2, Masoud Rahmati3, Abdolreza Kazemi 4
1- Dept of Physical Education, Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran
2- Dept of Exercise physiology, Faculty of Literature and Humanities, Islamic Azad University, Kerman Branch, Kerman, Iran
3- Dept of Physical Education, Faculty of Literature and Humanities, Lorestan University, Khoramabad, Iran
4- Dept of Physical Education, Faculty of Literature and Humanities, Vali-E-Asr University of Rafsanjan, Rafsanjan, Iran , rkazemi22@yahoo.com
Abstract:   (2229 Views)

Introduction: Motor neurons in spinal cord dictate the structural and contractile properties of muscles. Damage to motor neurons change muscles gene expression pattern. Given that Neurotrophin-4 (NT-4) is required for survival and normal function of muscle fibers, the aim of present study is investigation effect of Decreased activity model as Spinal Nerve Ligation on muscular NT-4 gene expression.
 
Materials & methods: Ten adult male wistar rats in the weight range of 250±20 gr randomly were divided into two groups including healthy control (C), Spinal nerve ligation (SNL). Over the six weeks after SNL, neuropathic pain behavior tests were conducted continually in groups. In the end of Sixth weeks, change of NT-4 gene expression in soleus muscle was measured with Real time technique.
 
Findings: Behavioral tests demonstrated that spinal nerve ligation induce thermal Hyperalgesia and mechanical Allodynia in the SNL group which decreased pain threshold seen in allover period of study (P≤0.05). Also, compared to the C group, NT-4 gene expression in soleus muscle was higher in SNL group significantly (P≤0.05).
 
Discussion & conclusions: The present study demonstrated that decreased activity in the form of SNL is associated with increased NT-4 gene expression in soleus muscle. However, the mechanisms and pathophysiologic issues of this increase are remaining elusive.
 

Keywords: Decreased activity, NT-4 gene expression, Neuropathic pain, Soleus muscle
Full-Text [PDF 788 kb]   (450 Downloads)    
Type of Study: Research |
Received: 2016/01/31 | Accepted: 2016/08/17 | Published: 2017/11/28
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Pourranjbar M, Mehri S, Rahmati M, Kazemi A. Investigation of Spinal nerve Ligation Effect on Muscular Neurotrophin-4 Gene Expression in Male Wistar Rats . sjimu. 2017; 25 (4) :161-170
URL: http://sjimu.medilam.ac.ir/article-1-3354-en.html


Volume 25, Issue 4 (11-2017) Back to browse issues page
مجله علمی پزوهشی دانشگاه علوم پزشکی ایلام scientific journal of ilam university of medical sciences
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