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:: Volume 23, Issue 7 (2-2016) ::
sjimu 2016, 23(7): 101-109 Back to browse issues page
Evaluating the Effect of Interferon Alpha Therapy on Plasma Levels of Hemocysteine in Patients with Hepatitis B
Abstract:   (3933 Views)

Introduction: Hyperhemocysteinemia is a risk factor for cardiovascular diseases. Some studies reported that plasma level of hemocysteine increases in patients with hepatitis B. The aim of this study was to peruse the effect of interferon-alpha on hemocysteine levels in patients with hepatitis B. Interferon alpha (IFN-α) is a therapeutic agent for treatment of hepatitis B.

Materials & methods: 20 patients with hepatitis B participated in this study. Plasma levels of hemocysteine assayed before and after IFN-α therapy and data were compared by using t-test and correlation.

Findings: Plasma levels of hemocysteine in patients group showed a significant increase compared to the control group (p<0.001). IFN-&alpha; therapy reduced plasma levels of hemocysteine compared to before treatment (p<0.0001) and hemocysteine levels after treatment did not show any significant difference compared to the control group (P> 0.806).

Discussion & Conclusions: Results showed that plasma levels of hemocysteine increased in patients with hepatitis B and treatment by Interferon-alpha reduced hemocysteine levels. Interferon-alpha was also able to inhibit atherogenesis development.

Keywords: Hemocysteine, Interferon-alpha (IFN-α), Hepatitis B
Full-Text [PDF 476 kb]   (1365 Downloads)    
Type of Study: Research | Subject: clinical biochemistry
Received: 2015/03/16 | Accepted: 2015/05/20 | Published: 2016/02/23
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Evaluating the Effect of Interferon Alpha Therapy on Plasma Levels of Hemocysteine in Patients with Hepatitis B. sjimu. 2016; 23 (7) :101-109
URL: http://sjimu.medilam.ac.ir/article-1-2601-en.html


Volume 23, Issue 7 (2-2016) Back to browse issues page
مجله علمی پزوهشی دانشگاه علوم پزشکی ایلام scientific journal of ilam university of medical sciences
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