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:: Volume 23, Issue 4 (10-2015) ::
sjimu 2015, 23(4): 135-147 Back to browse issues page
Application of Diffusion Tensor Imaging in Multiple Sclerosis Patients
Narges Akbarian Firozabadi1, Fariborz Faeghi 2, Ayoob Rostamzadeh3, Mehran Jalali1, Kavous Firoznia4
1- Shahid Beheshti University of Medical Sciences
2- Shahid Beheshti University of Medical Sciences , f_faeghi@sbmu.ac.ir
3- Kurdistan University of Medical Sciences
4- Tehran University of Medical Sciences
Abstract:   (5920 Views)

Introduction: The pathological changes associated with multiple sclerosis (MS) produce changes in uniformity of the neural networks of brain white matter that result in more perceptible changes on diffusion tensor imaging (DTI). Increase in mean diffusivity (MD) and reduction in fractional anisotropy (FA) on DTI seen in MS patients may be due to the degradation of membrane or other cell structures. The aim of this study was to investigate the pathological changes made in the brains of MS patients using the DTI technique.
 Materials & methods: This study was performed on 15 patients with multiple sclerosis. To investigate the location of plaques and normal appearing white matter (NAWM) some routine protocols for the brain, including T2-FLAIR and T2, were taken and to normalize the images of DTI, the T1 MPRAGE protocol was applied. After image processing using SPM, FSL, and MedINRIA software, the data were analyzed with the Mann-Whitney test.
Findings: The results showed that there is a significant difference between the mean of MD (mean=4.3±1.01) and FA (mean=0.24±0.05) values in MS plaques and the mean of MD (mean=2.1±1.1) and FA (mean=0.55±0.56) values in the normal white matter (NWM) tissue of the control group (P=0.00001). Comparing the data obtained from the NAWM tissue with expanded disability status scale (EDSS) of patients showed that patients with higher EDSS show higher MD values (P=0.004) and lower FA values than patients with lower EDSS (P=0.001).
 Discussion & Conclusion: This study showed that factors of MD and FA in DTI technique can provide valuable information as imaging biomarkers about the MS plaques.

Keywords: Magnetic resonance imaging, Diffusion tensor imaging, Multiple sclerosis, Mean diffusivity, Fractional anisotropy
Full-Text [PDF 678 kb]   (1607 Downloads)    
Type of Study: Research | Subject: nearology
Received: 2015/02/25 | Accepted: 2015/05/24 | Published: 2015/10/25
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Akbarian Firozabadi N, Faeghi F, Rostamzadeh A, Jalali M, Firoznia K. Application of Diffusion Tensor Imaging in Multiple Sclerosis Patients. sjimu. 2015; 23 (4) :135-147
URL: http://sjimu.medilam.ac.ir/article-1-2541-en.html

Volume 23, Issue 4 (10-2015) Back to browse issues page
مجله علمی پزوهشی دانشگاه علوم پزشکی ایلام scientific journal of ilam university of medical sciences
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