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:: Volume 23, Issue 4 (10-2015) ::
sjimu 2015, 23(4): 279-293 Back to browse issues page
Assessment of Degree of Agreement between Automated and Manual Volumetry for Quantification of Hippocampal Volume on MRI Images of Epileptic Patients
Mahsa Haji Abadian1, Fariborz Faeghi 2, Ayoob Rostamzadeh3, Mahmood Motamedi4, Homan Bahrami Motlagh4, Mohammad Reza Kaffashian5, Gholamreza Bakhshandepour1
1- Shahid Beheshti University of Medical Sciences
2- Shahid Beheshti University of Medical Sciences , f.drfaeghi@yahoo.com
3- Kurdistan University of Medical Sciences
4- Tehran University of Medical Sciences
5- Ilam University of Medical Sciences
Abstract:   (3837 Views)

Introduction: localizing of the epileptogenic zone is a key step in the preoperative assessment of patients with medically refractory medial temporal lobe epilepsy (mTLE). Quantitative measurement of hippocampal volume (HV) using a standard method of manual tracing is very time consuming, difficult and operator-dependent that is why several automated hippocampal volumetric methods are used. The purpose of this study was to assess the degree of agreement between the automated hippocampal volumetric methods and measurements obtained from standard method (manually) in mTLE patients.

Materials & methods: This study was performed in10 patients with mTLE, and 10 healthy controls participated. For each case, the right and left hippocampal volumes were measured using manual tracing method and three automated hippocampal volumetric methods include FSL, FreeSurfer and atlas-based. Degree of agreement between these methods was analyzed using statistical tests of the Pearson correlation coefficient and the Intra-class Correlation Coefficient (ICC).

Findings: The Pearson correlation coefficients of HV between the manual tracing and FreeSurfer methods were 0.80(right) and 0.88(left), between the manual tracing   and FSL methods were 0.80(right) and 0.79(left), and between the manual tracing   and atlas-based methods were 0.72(right) and 0.66(left). The ICCs of HV between the manual tracing and FreeSurfer methods were 0.80(right) and 0.87(left), between the manual tracing and FSL methods were 0.77(right) and 0.78(left), and between the manual tracing and atlas-based methods were 0.70(right) and 0.66(left).

Discussion & Conclusion: Findings of this study showed that automated methods could be valuable tools for the evaluation of epileptic patients and preoperative assessment.

Keywords: Magnetic resonance imaging, Manual volumetry, Automated volumetry, Hippocampus
Full-Text [PDF 1064 kb]   (1398 Downloads)    
Type of Study: Research | Subject: nearology
Received: 2015/02/15 | Accepted: 2015/05/20 | Published: 2015/12/22
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Haji Abadian M, Faeghi F, Rostamzadeh A, Motamedi M, Bahrami Motlagh H, Kaffashian M R et al . Assessment of Degree of Agreement between Automated and Manual Volumetry for Quantification of Hippocampal Volume on MRI Images of Epileptic Patients. sjimu. 2015; 23 (4) :279-293
URL: http://sjimu.medilam.ac.ir/article-1-2512-en.html


Volume 23, Issue 4 (10-2015) Back to browse issues page
مجله علمی پزوهشی دانشگاه علوم پزشکی ایلام scientific journal of ilam university of medical sciences
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