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Investigation of the Association between Rs13075270 and
Rs13092160 Polymorphisms of CCR1 and
CCR3 Genes with Behcet’s Disease
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Mahdieh Mohammadzadeh1   , Shohreh Zare Karizi * 2, Reza Mirfakhraie3 |
1- Dept of Genetics, Faculty of Biological Sciences, Islamic Azad University ,Varamin-Pishva Branch, Varamin, Iran
2- Dept of Genetics, Faculty of Biological Sciences, Islamic Azad University ,Varamin-Pishva Branch, Varamin, Iran , shohrehzare@yahoo.com
3- Dept of Medical Genetics, Faculty of Medicine, Shahid Beheshti University, Tehran, Iran |
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Abstract: (3790 Views) |
Introduction: Behcet's disease is an autoimmune disease that can affect various parts of the body. This disease manifests itself with skin, oral and ocular lesions. Although it is an idiopathic disease, various factors, including environmental and genetic factors, contribute to the onset of it. In this study, the association between two polymorphisms, namely rs13075270 and rs13092160 of CCR1 and CCR3 genes and susceptibility to Behcet’s disease were investigated in Iranian population.
Materials & Methods: Totally, 100 patients with Behcet's disease and 100 healthy individuals were selected in this study. After DNA sampling and extraction, polymorphisms of CCR1 and CCR3 receptor genes were examined using PCR-RFLP method. The findings were analyzed in SPSS software (Version 22). P-value less than 0.05 were considered statistically significant.
Findings: According to the results, the frequencies of CT genotype of rs13092160 polymorphism in the patient and control groups were 18% and 23%, respectively; moreover, the frequencies of TT genotype were 82% and 77%, respectively. Furthermore, the frequencies of CC genotype of rs13075270 polymorphism were 1% and 5%, the frequencies of CT genotype were 80% and 19%, and TT genotype were 19% and 76% in the patient and control groups, respectively.
Discussion & Conclusions: In rs13075270 polymorphism, CT genotype is associated with Behcet’s disease (P<0.005). Moreover, there is no significant difference between the patients with Behcet's disease and the control group regarding the rs13092160 polymorphism.
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| Keywords: Autoimmune diseases, Behcet’s disease, Chemokine receptor, Polymorphism |
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Full-Text [PDF 699 kb]
(1365 Downloads)
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Type of Study: Research |
Received: 2017/11/11 | Accepted: 2018/03/10 | Published: 2019/04/15
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