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Investigation the Effect of Valproate on Locomotor Activity,
Balance, Lipid Profile, and Serum Biochemical
Parameters before Sexual
Maturity in Rat
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Raha Zalkhani *    1, Hossein Najafzadevarzi2 , Ahmad Ali Moazi3 , Zohreh Ghotbeddin4 |
1- Dept of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran , rahazalkhani@gmail.com
2- Dept of Pharmacology, Faculty of Veterinary medicine, Shahid Chamran University of Ahvaz,Iran
3- Dept of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran
4- Dept of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran |
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Abstract: (3865 Views) |
Introduction: Valproate as an effective antiepileptic drug is used for the treatment of partial and generalized seizure in adults and children. This medication causes biochemical changes in liver functions and behavioral changes in childhood. Therefore, this study evaluated the effects of valproate on locomotor activity, balance, hepatic enzymes, and serum lipid profiles in immature female rats.
Materials & Methods: Postnatal female rats (23 days) were divided in two groups. The first group received valproate (200 mg/Kg/day) for two weeks and the second received saline. All injections were performed intraperitoneally. Locomotor activity and balance were evaluated using open field and rotarod apparatus, respectively. Subsequently, cholesterol (HDL, LDL, TC), triglyceride (TG), SGOT and SGPT enzymes in serum were measured.
Findings: Valproate decreased motor activity and increased hepatic enzymes (SGPT) and alkaline phosphatase. However, it had no effect on balance and serum lipid profiles.
Discussion &Conclusions: Subchronic injection of valproate has probably no effect on serum lipid profiles while increasing serum hepatic enzymes and reducing locomotor activity. Therefore, it seems that side effects of valproate occur with its long-term administration. |
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| Keywords: Biochemical parameters, Lipid profile, locomotor activity, Balance, Valproate, Rat |
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Full-Text [PDF 694 kb]
(1719 Downloads)
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Type of Study: Research |
Received: 2017/10/25 | Accepted: 2018/01/9 | Published: 2019/04/15
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