1. Gupta M, Desai K, Thanadar R, Kotwal A, Chindris AM. Thyroid: year-in-review 2024-2025. Endocr Pract. 2026; 32:280-85. doi: 10.1016/j.eprac.2025.12.014.

2. Yu D, Zhou H, Yang Y, Jiang Y, Wang T, Lv L, et al. The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats. Horm Behav. 2015; 69:106-15. doi: 10.1016/j.yhbeh.2015.01.003.

3. Urgatz B, Razvi S. Subclinical hypothyroidism, outcomes and management guidelines: a narrative review and update of recent literature. Curr Med Res Opin. 2023; 39:351-65. doi: 10.1080/03007995.2023.2165811.

4. Chaker L, Bianco AC, Jonklaas J, Peeters RP. Hypothyroidism. Lancet. 2017; 390:1550-62. doi: 10.1016/S0140-6736(17)30703-1.

5. Piccinni MP, Raghupathy R, Saito S, Szekeres-Bartho J. Cytokines, hormones and cellular regulatory mechanisms favoring successful reproduction. Front Immunol. 2021; 12:717808. doi: 10.3389/fimmu.2021.717808.

6. Van den Berghe G, Téblick A, Langouche L, Gunst J. The hypothalamus-pituitary-adrenal axis in sepsis- and hyperinflammation-induced critical illness: Gaps in current knowledge and future translational research directions. EBioMedicine. 2022; 84:104284. doi: 10.1016/j.ebiom.2022.104284.

7. Yao Z, Guo F, Tan Y, Zhang Y, Geng Y, Yang G, et al. Causal relationship between inflammatory cytokines and autoimmune thyroid disease: a bidirectional two-sample Mendelian randomization analysis. Front Immunol. 2024; 15:1334772. doi: 10.3389/fimmu.2024.1334772.

8. Mancini A, Di Segni C, Raimondo S, Olivieri G, Silvestrini A, Meucci E, et al. Thyroid hormones, oxidative stress, and inflammation. Mediators Inflamm. 2016; 2016:6757154. doi: 10.1155/2016/6757154.

9. Lai R, Yin B, Feng Z, Deng X, Lv X, Zhong Y, et al. The causal relationship between 41 inflammatory cytokines and hypothyroidism: Bidirectional two-sample mendelian randomization study. Front Endocrinol (Lausanne). 2024; 14:1332383. doi: 10.3389/fendo.2023.1332383.

10. Lear SA, Hu W, Rangarajan S, Gasevic D, Leong D, Iqbal R, et al. The effect of physical activity on mortality and cardiovascular disease in 130000 people from 17 high-income, middle-income, and low-income countries: the PURE study. Lancet. 2017; 390:2643-54. doi: 10.1016/S0140-6736(17)31634-3.

11. Krohn T, Hänscheid H, Müller B, Behrendt FF, Heinzel A, Mottaghy FM, et al. Maximum dose rate is a determinant of hypothyroidism after 131I therapy of Graves' disease but the total thyroid absorbed dose is not. J Clin Endocrinol Metab. 2014; 99:4109-15. doi: 10.1210/jc.2014-1347.

12. Klasson CL, Sadhir S, Pontzer H. Daily physical activity is negatively associated with thyroid hormone levels, inflammation, and immune system markers among men and women in the NHANES dataset. PloS One. 2022;17: e0270221. doi: 10.1371/journal.pone.0270221.

13. Aguiari P, Villani V, Liu YY, Carraro G, Brent GA, Perin L, et al. Hypothyroidism impairs skeletal muscle regeneration after injury by altering myogenic and nonmyogenic pathways. JCI Insight. 2026;11(6): e197761. doi: 10.1172/jci.insight.197761.

14. El Assar M, Álvarez-Bustos A, Sosa P, Angulo J, Rodríguez-Mañas L. Effect of physical activity/exercise on oxidative stress and inflammation in muscle and vascular aging. Int J Mol Sci. 2022; 23:8713. doi: 10.3390/ijms23158713.

15. Carr AC, Maggini S. Vitamin C and immune function. Nutrients. 2017; 9:1211. doi: 10.3390/nu9111211.

16. Yao L, Zhang M, Wang S, Yao Q, Chen S, Qin Z, et al. Ascorbic acid relieves neuropathic pain and depressive behavior by reducing inflammation and activating antioxidant responses. Mol Pain. 2025; 21:17448069251359598. doi: 10.1177/17448069251359598.

17. Movahhed Avval N, Fereidoni M. The Effect of vitamin C on inflammation induced by formalin in rats. J Adv Med Biomed Res. 2015; 23:122-30.

18. Chen L, Mao Y, Chen G. Association between total vitamin C intake and hypothyroidism among Hashimoto thyroiditis: National Health and Nutrition Examination Survey, 2007-2012. Br J Nutr. 2024; 132:1575-83. doi: 10.1017/S0007114524001715.

19. Wu J, Jia C, Wang Q, Li X. Association between vitamin C intake and thyroid function among U.S. adults: A population-based study. Front Endocrinol (Lausanne). 2024; 15:1462251. doi: 10.3389/fendo.2024.1462251.

20. Kazemi Tanha M, Nayebifar SH, Ghasemi E, Nosrat Zehi SH. The synergistic effect of nasturtium officinale extract and high-intensity interval training on fatty acid-binding protein 4 (FABP4) and high-sensitivity C-reactive protein (hs-CRP) in overweight subclinical hypothyroid patients: A randomized clinical trial. Sport Physiol. 2023; 14:177-200. doi: 10.22089/spj.2022.13463.2214.

21. Nabilpour M, Sadeghi A. Effect of eight-week aerobic moderate-intensity continuous training on IL-1β and IL-13 levels of soleus muscle tissue in male diabetic rats. IJDLD. 2021; 21:129-38.

22. Habibian M, Amirnia Shobi S, Zakeri Khatir E. The Effects of 8 weeks of regular aerobic exercise on the TNF-α levels and lipid profile in obese girls. J Sabzevar Univ Med Sci. 2021; 28:134-42.

23. Noor Z, Agustiningsih D, Soesatyo MH, Soejono SK. The effect of swimming exercise on thyroid function, spatial memory and anxiety in normal and propylthiouracil-induced hypothyroidism in Wistar rats. Physiol Pharmacol. 2021; 25:231-41. doi: 10.52547/ppj.25.3.231.

24. Shafia S, Mohammadi M. Treadmill exercise improves neuronal survival by inhibiting apoptosis in the prefrontal cortex of congenital hypothyroid rats. Koomesh. 2023;25: e152843.

25. Leandro CG, Levada AC, Hirabara SM, Manhães-de-Castro R, De-Castro CB, Curi R, et al. A program of moderate physical training for wistar rats based on maximal oxygen consumption. J Strength Cond Res. 2007; 21:751-6. doi: 10.1519/R-20155.1.

26. Khordad E, Alipour F, Beheshti F, Hosseini M, Rajabzadeh AA, Asiaei F, et al. Vitamin C prevents hypothyroidism associated neuronal damage in the hippocampus of neonatal and juvenile rats: A stereological study. J Chem Neuroanat. 2018; 93:48-56. doi: 10.1016/j.jchemneu.2017.11.011.

27. Kubiak K, Szmidt MK, Kaluza J, Zylka A, Sicinska E. Do dietary supplements affect inflammation, oxidative stress, and antioxidant status in adults with hypothyroidism or hashimoto's disease? A systematic review of controlled trials. Antioxidants (Basel). 2023; 12:1798. doi: 10.3390/antiox12101798.

28. Mehdi SF, Qureshi MH, Pervaiz S, Kumari K, Saji E, Shah M, et al. Endocrine and metabolic alterations in response to systemic inflammation and sepsis: A review article. Mol Med. 2025; 31:16. doi: 10.1186/s10020-025-01074-z.

29. Yamamoto S, Shimizu S, Kiyonaka S, Takahashi N, Wajima T, Hara Y, et al. TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nature Medicine. 2008; 14:738-47. doi: 10.1038/nm1758.

30. Hotchkiss RS, Moldawer LL, Opal SM, Reinhart K, Turnbull IR, Vincent JL. Sepsis and septic shock. Nat Rev Dis Primers. 2016; 2:16045. doi: 10.1038/nrdp.2016.45.

31. Lira FS, Koyama CH, Rosa JC, Zanchi NE, Batista ML, Seelaender M. Chronic exercise decreases cytokine production in healthy rat skeletal muscle. Cell Biochem Fun. 2009; 27:458461. doi: 10.1002/cbf.1594.

32. Rose GL, Skinner TL, Mielke GI, Schaumberg MA. The effect of exercise intensity on chronic inflammation: A systematic review and meta-analysis. J Sci Med Sport. 2021; 24:345-51. doi: 10.1016/j.jsams.2020.10.004.

33. Powers SK, Deminice R, Ozdemir M, Yoshihara T, Bomkamp MP, Hyatt H. Exercise-induced oxidative stress: Friend or foe? J Sport Health Sci. 2020; 9:415-25. doi: 10.1016/j.jshs.2020.04.001.

34. Brooks SV, Vasilaki A, Larkin M, McArdle A, Jackson J. Repeated bouts of aerobic exercise lead to reductions in skeletal muscle free radical generation and nuclear factor kappaB activation. J Physiol. 2008; 586:3979-90. doi: 10.1113/jphysiol.2008.155382.

35. Suh M, Kwon J, Wee W, Han Y, Kim J, Lee J. Protective effect of ascorbic acid against corneal damage by ultraviolet B irradiation: A pilot study. Cornea. 2008; 27:916-22. doi: 10.1097/ICO.0b013e31816f7068.

36. Genç B, Karaman M. Effect of ascorbic acid on oxidative stress parameters of fruit fly in the presence of Fe (II). Biol Trace Elem Res. 2024; 202:3810-15. doi: 10.1007/s12011-023-03960-1.