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Relationship Between the Platelet to Lymphocyte Ratio and Neutrophil to Lymphocyte Ratio with the Severity of Acute Coronary Syndrome in Ilam
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Sajjad Monghad Monfared1    , Aliashraf Mozafari2 , Yousef Mohamadi *3 , Abbas Soleimani4 |
1- School of Medicine, Ilam University of Medical Sciences, Ilam, Iran
2- Dept of Epidemiology, School of Health, Ilam University of Medical Sciences, Ilam, Iran
3- Dept of Anatomy, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran , yosefmohamadi1365@gmail.com
4- Dept of Cardiology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran |
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Abstract: (3 Views) |
Introduction: Platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio are simple and cost-effective inflammatory biomarkers, reflecting systemic inflammation, and play an important role in the pathophysiology of acute coronary syndrome. The aim of this study was to investigate the relationship between these markers and the severity of this disease in Ilam, Iran.
Materials & Methods: This cross-sectional study was conducted on 130 patients with acute coronary syndrome hospitalized in Mustafa Khomeini Hospital of Ilam. Platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, and severity of acute coronary syndrome were collected from patients' electronic medical records system. Severity of the syndrome was classified into three types: unstable angina, myocardial infarction with ST-segment elevation, and myocardial infarction without ST-segment elevation. Data analysis was performed using t-test, ANOVA, Kruskal-Wallis, Mann-Whitney, and nominal logistic regression in SPSS version 16.
Results: The mean of the platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio was significantly different in patients with different severities of acute coronary syndrome, such that high values of the platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio were significantly associated with the severity of acute coronary syndrome (p < 0.05). In addition, increasing neutrophil-to-lymphocyte ratio increased the risk of acute coronary syndrome in patients with ST-elevation myocardial infarction and myocardial infarction without ST-elevation compared to patients with unstable angina (p < 0.05).
Conclusion: High PLR and NLR were found to be associated with the severity of ACS in this study and reflect the inflammatory and thrombotic processes. Increased NLR was significantly associated with a greater risk of both STE-ACS and non-STE-ACS. Smoking and older age were also significant risk factors. PLR and NLR may be simple biomarkers for ACS risk stratification but need to be confirmed by larger prospective studies.
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| Keywords: Acute coronary syndrome, platelet, neutrophil, lymphocyte |
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Full-Text [PDF 868 kb]
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Editorial Note: Research |
Subject:
Clinical pathology
Received: 2026/05/31 | Accepted: 2026/06/22 | Published: 2026/09/27
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