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:: Volume 34, Issue 2 (5-2026) ::
Journal of Ilam University of Medical Sciences 2026, 34(2): 71-90 Back to browse issues page
The effect of alumina nanoparticles from hydroalcoholic extract of Rheum persicum on biofilm production genes in Pseudomonas aeruginosa
Sajad Karimi ghahfarokhi1 , Farhad Gilavand1 , Abdolrazagh Marzban2 , Amirarsalan Kavyanifard *3
1- Dept of Microbiology, Islamic Azad University, Khorramabad Branch, Khorramabad, Iran
2- Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran
3- Dept of Biology, Payame Noor University, Tehran, 1395-4697, Iran , kavyanifarda@pnu.ac.ir
Abstract:   (522 Views)
Introduction:  Pseudomonas aeruginosa is an opportunistic bacterium that is naturally resistant to antimicrobial substances. This bacterium is one of the most important causes of hospital-acquired infections in infants and burn patients. The aim of this study was to synthesise alumina nanoparticles using Rheum persicum hydroalcoholic extract and investigate its effect on biofilm production genes in P. aeruginosa.
Materials & Methods: In this study, alumina nanoparticles were successfully synthesised from hydraulic Rheum persicum extract. To ensure the formation of nanoparticles with UV-VIS absorption, SEM scan, FTIR spectrum, nanoparticle size and volume study, and XRD spectrum were performed, and then antimicrobial activity was investigated by determining MIC and MBC values. Finally, the expression of the mvfR and pslA biofilm generator genes was evaluated.
Results: The results of the different analyses showed that the alumina nanoparticles are produced from R. persicum hydraulic extract. The MIC and MBC values of the nanoparticles were determined as 1000 and 1500 micrograms per ml, respectively. The results of the effect of nanoparticles on biofilm genes showed a significant decrease in expression of mvfR and pslA genes.
Conclusion: The results show that the efficiency of this nanoparticle is very good and can be used to inhibit the growth of this bacterium.

 
Keywords: Antibofilm, Alumina Nanoparticle, Pseudomonas aeruginosa, mvfR, pslA
Full-Text [PDF 1190 kb]   (184 Downloads)    
Editorial Note: Research | Subject: Medical microbiology
Received: 2025/07/31 | Accepted: 2026/02/25 | Published: 2026/05/26
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Karimi ghahfarokhi S, Gilavand F, Marzban A, Kavyanifard A. The effect of alumina nanoparticles from hydroalcoholic extract of Rheum persicum on biofilm production genes in Pseudomonas aeruginosa. J. Ilam Uni. Med. Sci. 2026; 34 (2) :71-90
URL: http://sjimu.medilam.ac.ir/article-1-8709-en.html
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Volume 34, Issue 2 (5-2026) Back to browse issues page
مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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