[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 27, Issue 6 (1-2020) ::
sjimu 2020, 27(6): 96-105 Back to browse issues page
e Prevalence of Different Genotypes CASQ1 rs2275703 (A / C) in Patients with Type 2 Diabetes Mellitus
Rasoul Nasirikalmarzi1 , Somayee Bodaghi2, Azad Fatahirad3, Fatemeh Keshavarzi 4
1- Lung Diseases and Allergy Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran
2- Dept of Biology, Islamic Azad University, Sanandaj Branch, Sanandaj, Iran
3- Tohid Hospital, Kurdistan University of Medical Sciences, Sanandaj, Iran
4- Dept of Biology, Islamic Azad University, Sanandaj Branch, Sanandaj, Iran , gol.keshavarzi@gmail.com
Abstract:   (693 Views)
Introduction: Genetic factors play an important role in the development of type 2 diabetes. The aim of this study was to investigate the prevalence of polymorphism CASQ1 (rs2275703) in 100 patients with type 2 diabetes mellitus (T2DM) in Kurdistan, Iran.
 
Materials & Methods: This study was conducted based on a case-control design. After obtaining the informed consent, the blood samples were obtained from patients with T2DM who were over 35 years of age. In total, 100 blood samples from the patient group and 100 blood samples from the control group (with matched age and gender) were assessed for the status of CASQ1 (rs2275703) using Tetra-Arms polymerase chain reaction method. The data were then analyzed statistically. Ethics code: IR.MUK.REC.1396/319
 
Findings: Out of 100 healthy individuals (60 males and 40 females), 34 and 47 ones had genotype AA4, respectively. Moreover, 4 and 13 cases had genotype AC, and 0 and 2 individuals had genotype CC. Additionally, out of all healthy individuals and diabetic patients, 81 and 71 cases had genotype AA, respectively; moreover, 17 and 25 cases had genotype AC. In addition, out of 100 healthy individuals and 100 patients, 2 and 4 cases had genotype CC, respectively. There was no significant relationship between CASQ1 rs2275703 polymorphism and T2DM (P=0.241).
 
Discussion & Conclusions: According to the results, no significant relationship was observed between CASQ1 (rs2275703) polymorphism and T2DM in the population under study.
Keywords: polymorphism|CASQ1 rs2275703(A/C)|type 2 diabetes ,
Full-Text [PDF 798 kb]   (125 Downloads)    
Type of Study: Research | Subject: genetic mlvkly
Received: 2019/05/17 | Accepted: 2019/11/24 | Published: 2020/06/8
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Nasirikalmarzi R, Bodaghi S, Fatahirad A, keshavarzi F. e Prevalence of Different Genotypes CASQ1 rs2275703 (A / C) in Patients with Type 2 Diabetes Mellitus. sjimu. 2020; 27 (6) :96-105
URL: http://sjimu.medilam.ac.ir/article-1-5684-en.html


Volume 27, Issue 6 (1-2020) Back to browse issues page
مجله علمی پزوهشی دانشگاه علوم پزشکی ایلام scientific journal of ilam university of medical sciences
Persian site map - English site map - Created in 0.19 seconds with 31 queries by YEKTAWEB 4271