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Elevated Serum Levels of IL-6 and TNF-α in Patients with Irritable Bowel Syndrome
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Marzieh Azizyan1    , Habibolah Turki2 , Asad Mirzaei3 |
1- Dept of Biology, Faculty of Basic Sciences, Arak Branch, Islamic Azad University, Arak, Iran
2- Infectious and Tropical Diseases Research Center, Health Research Center, Hormozgan University of Medical Sciences, Hormozgan, Iran
3- Dept of Medical Parasitology, Paramedical Faculty, Ilam University of Medical Sciences, Ilam, Iran |
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Abstract: (4509 Views) |
Introduction: Irritable bowel syndrome (IBS) is accompanied by abdominal pain and intestinal discomforts. A line of evidence shows that the immune system plays important roles in the pathogenesis of the disease. Two main cytokines directing the immune system are IL-6 and TNF-α which may play a role in the immunopathogenesis of this disease. The present study aimed at investigating the serum levels of these cytokines in patients suffering from IBS.
Materials & Methods: This comparative case-control study was conducted on 40 patients suffering from IBS (case group) and 40 people who were affected by the symptoms of gastrointestinal disorders but not suffering from IBS (control group). The serum levels of TNF-α and IL-6 cytokines were measured using enzyme-linked immunosorbent assay. The amount of the above-mentioned cytokines was compared using independent-t-test in both groups. Ethics code: EC/92/H/132
Findings: The results showed significantly higher levels of IL-6 and TNF-α in IBS patients, compared to those in the control group (P=0.0001). According to the results obtained from the Spearman rank correlation coefficient, there was a strong correlation between the serum levels of IL-6 (Ρ=0.799, P=0.000) and TNF-α (Ρ=0.788, P=0.000) cytokines with IBS development.
Discussion & Conclusions: This study shows that serum levels of TNF-α and IL-6 cytokines are significantly higher in the case group with IBS. Moreover, there is an association between serum levels of IL-6 and TNF-α with the pathogenesis of IBS.
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| Keywords: Enzyme-linked immunosorbent assay, Interleukin-6, Irritable bowel syndrome, Tumor necrosis factor-α |
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Full-Text [PDF 816 kb]
(2873 Downloads)
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Type of Study: Research |
Received: 2018/02/26 | Accepted: 2019/03/5 | Published: 2019/06/15
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