[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 26, Issue 3 (9-2018) ::
sjimu 2018, 26(3): 177-186 Back to browse issues page
Histopathologic and biochemical study of zinc oxide nanoparticles effect on renal tissue in rats
Mohammad Hosseini Seyed 1, Reza Amani 2 , Vahid Razavimehr Seyed3 , Amir Hossein Moshrefi 3 , Mohammad Hasan Aghajanikhah 3
1- Department of Pathobiology, Islamic Azad University, Babol Branch, Babol, Iran , dr_hosseini2323@yahoo.com
2- . Young Researchers and Elite Club, Islamic Azad University, Babol Branch, Babol, Iran
3- Young Researchers and Elite Club, Islamic Azad University, Babol Branch, Babol, Iran
Abstract:   (361 Views)
Introduction: Zinc oxide nanoparticles that are used for industrial and domestic purposes can cause a widespread environmental contamination. Regarding this, the present study was conducted to investigate the effect of zinc oxide nanoparticles on renal tissue in terms of bioaccumulation of nanoparticles, histopathology, serum biochemical index, and oxidative damage.
 
Materials & Methods: This experimental study was conducted on 80 male Wistar rats that were divided into eight groups, including one control group, one sham group (receiving saline), and six groups administered zinc oxide nanoparticles at doses of 4, 8, 25, 50, 100, and 200 mg/kg for 28 days twice a week. The measurement of blood urine nitrogen (BUN), uric acid, and creatinine was accomplished using an autoanalyzer. Furthermore, histopathological examinations were performed after tissue processing. The digestion of the renal tissue by nitric-perchloric acid provided suitable solutions for the determination of zinc oxide nanoparticles by atomic absorption spectrometry.
 
Findings: According to the results, the histopathological lesions in the renal tissue at the dose of 200 mg/kg included glomerular proliferation and fibrosis. The groups treated with zinc oxide nanoparticles showed a higher increase in the serum levels of BUN and creatinine, compared with the control group, which indicated renal toxicity. Furthermore, a significantly higher level of zinc oxide nanoparticles was observed in the renal tissue of the groups receiving higher doses than those of the other groups (P<0.05).
 
Discussion & Conclusions: The findings of the current study revealed that zinc oxide nanoparticles exerted a destructive effect on the kidney. Moreover, it was found that these nanoparticles had a toxic effect on the renal tissue at a high concentration.
Keywords: rat, kidney, zinc oxide, nanoparticle
Full-Text [PDF 1004 kb]   (163 Downloads)    
Type of Study: Research | Subject: pathology
Received: 2017/12/21 | Accepted: 2018/05/28
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA code


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Hosseini M, Amani R, Razavimehr V, Moshrefi A H, Aghajanikhah M H. Histopathologic and biochemical study of zinc oxide nanoparticles effect on renal tissue in rats . sjimu. 2018; 26 (3) :177-186
URL: http://sjimu.medilam.ac.ir/article-1-4734-en.html


Volume 26, Issue 3 (9-2018) Back to browse issues page
مجله علمی پزوهشی دانشگاه علوم پزشکی ایلام scientific journal of ilam university of medical sciences
Persian site map - English site map - Created in 0.24 seconds with 31 queries by YEKTAWEB 3781