[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 25, Issue 5 (1-2018) ::
sjimu 2018, 25(5): 120-132 Back to browse issues page
Effect of Soybean Consumption on Histometry and Histochemistry of Tibial Plateau Cartilage in Female NMRI Mice after Osteoarthritis Induction
Reyhaneh Hooshmandabbasi Dr.1, Zahra Tootian Prof. 2, Hasan Morovati Prof.1, Simin Fazelipour Prof.3, Bahador Shojaei Prof.4, Ali Kazemian Dr.1
1- Dept of Basic Sciences, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran
2- Dept of Basic Sciences, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran , ztotian@ut.ac.ir
3- Dept of Anatomy, Tehran Medical Branch, Islamic Azad University, Tehran, Iran
4- Dept of Basic Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran
Abstract:   (3108 Views)
Introduction: Osteoarthritis is the most frequent knee joint disorder among old generation where it causes serious motion limitation. The objective of present study is investigating the effects of a diet containing soybean meal ingestion on relative treatment effect on knee articular cartilage in osteoarthritis induced mice.
 
Material & methods: Fifty immature female NMRI mice were accidentally divided into five groups. Control group received tap water and normal diet for three months. Sham group, as induced osteoarthritis model, received Ciprofloxacin by stomach Gavage method over two weeks, 20 Mg/kg of their body weight daily. First experimental group were osteoarthritis induced over two weeks and then received null soybean meal diet by three months. The second experimental group, were fed with designed diet based on %15 soybean meal during these three months. The third experimental group was ingested with the designed diet after osteoarthritis induction. After the experimental period, values of cartilage thickness at the middle part of tibial plateau, concentration of the extracellular matrix, and concentration of alkaline phosphatase in blood serum were determined among the groups.
 
Findings: Comparison between the groups showed that among the groups which were fed with the diet based on %15 soybean meal either with or without osteoarthritis induction, not only the cartilage thickness at the middle part of tibial plateau but also the concentration of the glycoproteins in extracellular matrix was significantly higher than those of the groups which received the normal diet (p<0.05). Furthermore, in those groups which received the designed diet either with or without osteoarthritis induction, more concentration of alkaline phosphatase in blood serum was measured. This difference, however, was not significant.
 
Discussion & conclusions: Regarding the positive effects of the designed diet based on soybean meal on cartilage, addition of soybean meal in regimen in order to decrease the incidence of articular disorders can be recommended.
 
Keywords: Soybean meal, Osteoarthritis, Tibial plateaus cartilage, Histometry
Full-Text [PDF 973 kb]   (556 Downloads)    
Type of Study: Research |
Received: 2017/06/28 | Accepted: 2017/10/22 | Published: 2018/01/15
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Hooshmandabbasi R, Tootian Z, Morovati H, Fazelipour S, Shojaei B, Kazemian A. Effect of Soybean Consumption on Histometry and Histochemistry of Tibial Plateau Cartilage in Female NMRI Mice after Osteoarthritis Induction. sjimu. 2018; 25 (5) :120-132
URL: http://sjimu.medilam.ac.ir/article-1-4409-en.html


Volume 25, Issue 5 (1-2018) Back to browse issues page
مجله علمی پزوهشی دانشگاه علوم پزشکی ایلام scientific journal of ilam university of medical sciences
Persian site map - English site map - Created in 0.19 seconds with 30 queries by YEKTAWEB 4272