[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 24, Issue 4 (11-2016) ::
sjimu 2016, 24(4): 83-94 Back to browse issues page
The Microscopic and Ultra Structural Study of Testicular Tissue Following Time Dependent Administration of Methylphenidate in Adult Rats
Zahra Mousavi Pourgohar1, Davoud Kianifard Dr 2, Emad Khalilzadeh Dr1
1- Dept of Basic Sciences, Faculty of Veterinary Medicine, Tabriz University, Tabriz, Iran
2- Dept of Basic Sciences, Faculty of Veterinary Medicine, Tabriz University, Tabriz, Iran , davoudkianifard@gmail.com
Abstract:   (4097 Views)

Introduction: Testicular tissue is susceptible to environmental risk factors. Structural and functional alterations in spermatogenesis are the most important factors involved in fertility complications. Methylphenidate is amphetamine derivatives. This drug can approve for treatment of attention-deficit/hyperactivity disorder (ADHD), tachycardia syndrome, narcolepsy, depression. There is a little data about the effects of methylphenidate on testicular tissue. In this study, time dependent effects of methylphenidate were evaluated on testicular tissue in microscopic and ultrastructural levels.

Materials & methods: 30 adult Wistar rats were divided into three groups as control, short-term methylphenidate (10 mg/kg/day) treated for two weeks and long-term methylphenidate (10 mg/kg/day) treated for eight weeks. Histomorphological and ultrastructural assessments were prepared on testicular tissue through routine histologic and electron microscopic methods.

Findings: Some alterations such as tubular atrophy and transformation and disarrangement of spermatogenic cells were observed in testicular tissue following time dependent administration of methylphenidate. Deformation of mitochondria, increment of collagen fibers and basement membrane thickness, were the main cellular and structural alterations observed in ultrastructural level.

Discussion & conclusions: The results of this study indicated that the process of spermatogenesis reduces temporary following short term administration of methylphenidate; however, it seems that repeated administration of methylphenidate progressively leads to some degrees of tissue habitation and resistance.

Keywords: Methylphenidate, Rat, Testicular tissue, Ultrastructure
Full-Text [PDF 1547 kb]   (3042 Downloads)    
Type of Study: Research | Subject: anatomy
Received: 2015/12/30 | Accepted: 2016/04/9 | Published: 2016/11/14
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mousavi Pourgohar Z, Kianifard D, Khalilzadeh E. The Microscopic and Ultra Structural Study of Testicular Tissue Following Time Dependent Administration of Methylphenidate in Adult Rats. sjimu. 2016; 24 (4) :83-94
URL: http://sjimu.medilam.ac.ir/article-1-3281-en.html


Volume 24, Issue 4 (11-2016) Back to browse issues page
مجله علمی پزوهشی دانشگاه علوم پزشکی ایلام scientific journal of ilam university of medical sciences
Persian site map - English site map - Created in 0.18 seconds with 31 queries by YEKTAWEB 4241