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:: Volume 24, Issue 4 (11-2016) ::
sjimu 2016, 24(4): 21-31 Back to browse issues page
The Effect of Endurance Exercise Training and Atorvastatin on VEGF in Rat Following Experimental Myocardial Infarction
Akbar Azamian Jazi 1, Mohammad Reza Haffezi2, Hamid Opera3, Hadi Abdi4
1- Dept of Exercise Physiology, Shahrekord University, Shahrekord, Iran , azamianakbar@yahoo.com
2- Dept of Pathobiology, Faculty of Medicine, Ilam University of Medical Science, Ilam, Iran
3- Dept of Exercise Physiology, Shahrekord University, Shahrekord, Iran
4- . Dept of Physical Education,Payame Noor University, Tehran, Iran
Abstract:   (5288 Views)

Introduction: Statins and exercise training may have synergic beneficial effects on angiogenesis process following myocardial infarction. Therefore, the present study aimed to investigate the effect of endurance exercise training (EET), atorvastatin and their combination on expression of vascular endothelial growth factor (VEGF) in the cardiac muscle of male rat following experimental myocardial infarction.

Materials & methods: 45 rats (8-10 weeks old, 230 ±10 g body weight) were randomly divided to five groups: Sham, control, EET, atorvastatin, and EET + atorvastatin. Myocardial infarction was induced by subcutaneous injection of isoprenaline (150 mg/kg) in two consecutive days. Drug and training interventions were initiated 2 days after infarction and continued for 4 weeks. In order to assess the expression of VEGF, immunohistochemical staining was used. Data were analyzed by using one-way analyses of variance (ANOVA) and scheffe test at P<0.05 level.

Findings: VEGF expression in the atorvastatin group was significantly less than the control group (P=0.006). Also, VEGF expression in the Combined (EET + atorvastatin) and EET groups was not significant (P=0.534 and P=0.055 respectively), but its expression was significantly higher in the combined group (EET + atorvastatin) compared to the EET group (P=0.002) and atorvastatin group (P=0.001).

Discussion & conclusion: It seems that combination of EET and atorvastatin compared to EET and or atorvastatin alone has a favorable effect on VEGF expression and as a result, on angiogenesis process following myocardial infarction. 

Keywords: Endurance exercise training, Atorvastatin, VEGF, Myocardial infarction, Rat
Full-Text [PDF 624 kb]   (2062 Downloads)    
Type of Study: Research | Subject: Physical Education
Received: 2015/09/7 | Accepted: 2015/10/25 | Published: 2016/10/31
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Azamian Jazi A, Haffezi M R, Opera H, Abdi H. The Effect of Endurance Exercise Training and Atorvastatin on VEGF in Rat Following Experimental Myocardial Infarction. sjimu. 2016; 24 (4) :21-31
URL: http://sjimu.medilam.ac.ir/article-1-3032-en.html


Volume 24, Issue 4 (11-2016) Back to browse issues page
مجله علمی پزوهشی دانشگاه علوم پزشکی ایلام scientific journal of ilam university of medical sciences
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