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:: Volume 18, Issue 2 (2010 2010) ::
sjimu 2010, 18(2): 30-36 Back to browse issues page
Furazolidone, Amoxicillin, Omeprazole With or Without Bismuth for Eradication of Helicobacter Pylori in Peptic Ulcer Disease
Abstract:   (14157 Views)
Introduction: Furazolidone has been introduced as an effective drug against helicobacter pylori infection in Iran, but intolerable side-effects may limit its use. We compared quadruple and triple furazolidone-based regimens to achieve an economically affordable regimen with acceptable efficacy rate and fewer complications. Matherials & Methods: Patients with H.pylori positive peptic ulcer disease were randomly divided into two groups. They were treated with amoxicillin 1gm/BID, furazolidone 200 mg/BID, omeprazole 20mg/BID with and without bismuth sub-citrate 240 mg/BID for two weeks (AFOB & AFO regimens, respectively) H.pylori eradication was confirmed by 13C-urea breath test 12 weeks after the end of the treatment. Findings: Eighty six patients were enrolled but 16 ones discontinued their therapy or follow-up. The eradication rates in AFOB & AFO were 85.3% and 61.1% by per-protocol analysis, respectively (P=0.02), and 67.4% & 51.2% by intention–to-treat analysis respectively (P<0.05). The most frequent adverse effects in the two study groups were weakness, nausea, anorexia and dizziness that demonstrated no significant differences. Discussion & Conclusion: In this study, furazolidone-based triple therapy (without bismuth) was not recommended for H.pylori eradication, due to the lower eradication rate and unchanged frequency of adverse effects.
Keywords: gastric ulcer, H.pylori, eradication, triple therapy, quadruple therapy
Full-Text [PDF 231 kb]   (3390 Downloads)    
Type of Study: Research | Subject: General
Received: 2011/06/8 | Accepted: 2015/04/8 | Published: 2015/04/8
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Furazolidone, Amoxicillin, Omeprazole With or Without Bismuth for Eradication of Helicobacter Pylori in Peptic Ulcer Disease. sjimu. 2010; 18 (2) :30-36
URL: http://sjimu.medilam.ac.ir/article-1-291-en.html

Volume 18, Issue 2 (2010 2010) Back to browse issues page
مجله علمی پزوهشی دانشگاه علوم پزشکی ایلام scientific journal of ilam university of medical sciences
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