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The Evaluation of Lavender Aqueous Extract on Human Fibroblast Cells
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S Dalirian   , S Haidari kashl , M Zamanian azodi * 1, R Omidi , R Roeintan , R Hoseini |
| 1- , mona.azodi@gmail.com |
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Abstract: (19892 Views) |
| Introduction: Application of herbals subst-ances has been prevalent in the treatment of neoplasm diseases such as cancers. Laven-der has different biological activates and aqueous extracts of the plant has been shown promising future in the treatment of cancer neurodegenerative diseases.
Materials & Methods: The lavender plant and its derivative substances were prepared from the herbarium of Shahid Beheshti University. Fibroblast cells were cultured at RPMI 1640 medium (containing 20% fetal bovine serum and 5% CO2 gas at 37ºC) to achieve appropriate cell numbers. Microscopic studies were performed in the presents of 100 μgml-1 of the extract. MTT assay was applied for cell survival determi-nation in the present of different concentrations of the extract from 0 to 100 μgml-1.
Findings: Viability test and morphological studies indicated that the population of fibr-oblast cells decreased significantly at the concentrations of 0 to 100 μgml-1 of the lavender extract.
Discussion & Conclusion: It could con-clude that application of the aqueous extract of lavender should be carry out under certa-in consideration due to its adverse side effects that might accompany with its eff-ective dosages in cancer therapy. In addi-tion, in vivo studies would be crucial to confirm cytotoxic effects on cancer and normal cells. |
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| Keywords: lavender aqueous extract, fibr-oblast, MTT assay, cytotoxic effects |
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Full-Text [PDF 310 kb]
(4861 Downloads)
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Type of Study: Research |
Subject:
Medical microbiology
Received: 2013/06/11 | Accepted: 2013/09/1 | Published: 2013/09/1
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