@article{ author = {Vesali-Akbarpour, leila and SamavatiSharif, Mohammad Ali and Heidarianpour, Ali}, title = {The Effects of Endurance Swimming Plus Vitamin C Supplement on the Indices of Oxidative Stress among Male Rats}, abstract ={Introduction: Majority of researches have referred to reduction of stress oxidative, during consumption of antioxidant supplements or exercise training. The aim of the present study, was to investigate "the effect of endurance swimming training plus consumption of vitamin C supplement, on the indices of oxidative stress among male wistar rats". Materials & methods: Twenty four male wistar rats weighing 250 to 300 g, were randomly divided into four groups:1-Taining (T), 2- Training plus vitamin C (T &VC), 3- control (C), and 4- control plus vitamin C (C &VC).Training groups participated in a swimming program 5 d/w, 1 h/d, for ten weeks. Using vitamin C supplement (100 mg/kg) ) started one week before starting training protocol, and continued to the end of tenth week. One day after the end of training protocol, sampling blood of rats were obtained to measure the indices of oxidative stress including malondyaldehyde (MDA), catalase (CAT), uric acid (U.A), and total antioxidant capacity (TAC). Results were analyzed using the one-way ANOVA followed by a Tukey test. Significance level was 0.05. Findings: The results of this research indicate that T &VC significantly reduced the level of MDA in comparison to C group (P = 0.008). A significant increase in the level of TAC was also observed in C &VC group in comparison to T group (P = 0.01). But there was no significant difference in the level of CAT and U.A. Discussion & conclusions: In conclusion, results of the current study indicates that consumption of VC may decrease the lipid peroxidation and increase the level of TAC, while it did not affect CAT and U.A antioxidants.}, Keywords = {Endurance swimming, Oxidative stress, Rat, Vitamin C}, volume = {24}, Number = {6}, pages = {1-10}, publisher = {Ilam University of Medical Sciences}, doi = {10.18869/acadpub.sjimu.24.6.1}, url = {http://sjimu.medilam.ac.ir/article-1-3015-en.html}, eprint = {http://sjimu.medilam.ac.ir/article-1-3015-en.pdf}, journal = {Journal of Ilam University of Medical Sciences}, issn = {1563-4728}, eissn = {2588-3135}, year = {2017} } @article{ author = {Parandin, Rahmatollah and BehnamRassouli, Morteza and MahdaviShahri, Nasser}, title = {Evaluation of Neonatal Exposure to Mycoestrogens Zearalenone and Alpha-zearalenol on Puberty and Reproductive Function in Female Mice}, abstract ={Introduction: It is well known that exposure to estrogenic compounds during critical and sensitive periods of lifespan could result in adverse effects on the development and function of reproductive system. In the present study, we examined the effects of neonatal mycoestrogens Zearalenone (Zen) and alpha-zearalenol (α-Zol) exposure on the onset of puberty and reproductive parameters such as estrous cycle and ovarian follicle pool in female mice. Materials & methods: Pups were injected subcutaneously at postnatal days (PND) 1-5 with sesame oil, estradiol benzoate (EB, 20µg/kg bw), Zen (0.2, 1, 2mg/kg bw) and alpha-Zol(0.2, 1, 2mg/kg bw). The control group received no treatment. Vaginal opening and estrous cycle were monitored from PND 23 to 70. Animals were sacrificed at PND 70, and blood and ovary were collected. Finding: Advanced vaginal opening, disrupted estrous cycles and decreased follicular pool were significantly observed in EB, 1 and 2 Zen and 1 and 2 α-Zol. Also, LH and estradiol levels impaired. Discussion & conclusions: Neonatal exposure to mycoestrogens accelerated the onset of puberty but decreased reproductive parameters in female mice. These alterations could result from disruption anywhere within the hypothalamic-pituitary-gonadalaxis in particular estrogen-sensitive neuronal populations of hypothalamus.}, Keywords = {Zearalenone, Reproducrive functions, Puberty, Female mice}, volume = {24}, Number = {6}, pages = {11-22}, publisher = {Ilam University of Medical Sciences}, doi = {10.18869/acadpub.sjimu.24.6.11}, url = {http://sjimu.medilam.ac.ir/article-1-3102-en.html}, eprint = {http://sjimu.medilam.ac.ir/article-1-3102-en.pdf}, journal = {Journal of Ilam University of Medical Sciences}, issn = {1563-4728}, eissn = {2588-3135}, year = {2017} } @article{ author = {PayedarArdakani, Mojtaba and Saki, Behzad and Kordi, Mohammad and Gaieni, Abbasali}, title = {Effect of Endurance Training on Plasma AGRP and NPY Levels in Wistar Rats}, abstract ={Introduction: Agouti-Related Protein (AGRP) and Neuropeptide Y (NPY) are neuropeptidesthat involved in appetite control. Few studies have been done on the long-term effects of endurance training on these neuropeptides.The purpose of this study was to investigate the effect of 16 weeks of endurance training on plasma AGRP and NPY levels in Wistar rats. Materials & methods: 20 male young Wistar rats, with mean ages of 50 to 60 days and the average weight of 158 ± 10 g were randomly divided into two groups: control (n = 10) and training (n = 10). Training program was Endurance training on treadmill for 50-60 min/d, 5d/wk at 25-30 m/min, which is equal to 65-85% VO2max, for 16 weeks. After 16 weeks, fasting blood sampling was conducted 24 hours after the last training session. t test was used for data analyses. Statistical significance was set at p<0.05. Findings: The results of the study indicated that endurance training with 65-85% of vo2 max causes a significant increase in plasma AGRP (p=0.001) and non-significant increase in plasma NPY levels in training group compared to control group. Discussion & conclusions: It seems that endurance training causes a negative energy balance in rats, and to compensate this negative energy balance, plasma AGRP increases significantly and plasma NPY increases insignificantly (increase by more than 23%).}, Keywords = {Endurance training, AGRP, NPY, Wistar rats}, volume = {24}, Number = {6}, pages = {23-32}, publisher = {Ilam University of Medical Sciences}, doi = {10.18869/acadpub.sjimu.24.6.23}, url = {http://sjimu.medilam.ac.ir/article-1-2960-en.html}, eprint = {http://sjimu.medilam.ac.ir/article-1-2960-en.pdf}, journal = {Journal of Ilam University of Medical Sciences}, issn = {1563-4728}, eissn = {2588-3135}, year = {2017} } @article{ author = {Mirzaei, Nadia and Shakarami, Fatemeh and Ajamian, Farzam and Hamidimadani, Ali and Sohani, Mohammad mehdi}, title = {The Analysis of HDAC1 Gene Expression Alteration in Patients with Prostate Cancer}, abstract ={Introduction: Chromatin Epigenetic changes have a key role in pathophysiology of prostate cancer. The most important epigenetic changes are change in DNA methylation, histones modifications, changes in chromatin status and micro RNAs regulatory patterns which are related to tumor creation. Histone deacetylases (HDACs) comprise a large family of enzymes which act as key regulators of nucleosomal histone consistency. HDACs have a great role to start and develop prostate cancer which is due to changes they create. Epigenetic modifications, in particular DNA hypermethylation and histone acetylation have an essential role in the regulation of genes that protect against prostate cancer. Since epigenetic changes are reversible, they are interesting targets for cancer therapy. Many epi-drugs such as histone deacetylase inhibitors (HDACi) show anti-cancer properties in either cell culture or in the animal models of prostate cancer.  Materials & methods: In this case-control study, RNA extraction was performed on samples then the expression of HDAC1 in human prostate cancer using reverse-transcription polymerase chain reaction (RT-PCR). This study was conducted comparing 20 patients diagnosed with prostate cancer to 20 disease free control subjects. Findings: Our findings suggest that the expression of HDAC1 mRNA is tangible and a significant difference was observed between patients and control subjects. Discussion & conclusions: These results imply that HDAC1 mRNA expression could have potential as a marker and may have prognostic implications for Prostate cancer progression.}, Keywords = {Epigenetics, Histones modifica-tions, Gene expression, Histonedeacetylase (HDAC), Histone deacetylase Inhibitor (HDACi), Prostate cancer}, volume = {24}, Number = {6}, pages = {33-40}, publisher = {Ilam University of Medical Sciences}, doi = {10.18869/acadpub.sjimu.24.6.33}, url = {http://sjimu.medilam.ac.ir/article-1-2845-en.html}, eprint = {http://sjimu.medilam.ac.ir/article-1-2845-en.pdf}, journal = {Journal of Ilam University of Medical Sciences}, issn = {1563-4728}, eissn = {2588-3135}, year = {2017} } @article{ author = {NikoseyrJahromi, Mohammad and Ranjbar, Reza and KhaksarMahabadi, Mahmood and Morovati, Hasan and Najafzadehvarzi, Hosey}, title = {Effects of Curcumin on Histologic Lesions of Testis Induced by Aflatoxin B1 in Rat Offspring before and after Puberty}, abstract ={Introduction: This study was done to evaluate the use of curcumin to protect testicular tissue in offspring which their mother was exposed to aflatoxin. Material & methods: Seventy adult female vistar rats were divided to control, sham and five experimental groups. Rats received serum physiology (the same volume a drugs), dimethyl sulfuxide (the same volume of drugs), Aflatoxin B1 (0.25 mg/kg), Aflatoxin B1 and curcumin (0.25 and 50 mg/kg), Aflatoxin B1 and curcumin (0.25 and 100 mg/kg), curcumin 50 mg/kg and curcumin 100 mg/kg intraperitoneally in the control and experimental groups. For histologic studies, testis samples were taken from male offspring at 1, 4 and 8 weeks. Samples fixed in formalin, 6µ thickness slides were prepared and stained with H&E. Findings: In all times of sampling diameter of seminiferous tubule, number of germ cells and thickness of epithelium of seminiferous tubule in rats received aflatoxin decreased compared to control but these changes were not significant. In rats which received curcumin all parameters increased significantly. Discussion & conclusion: Our results showed that curcumin could compensate undesirable effects of aflatoxin B1.}, Keywords = {Aflatoxin B1, Curcumin, Testis, Histology, Morphometry}, volume = {24}, Number = {6}, pages = {41-53}, publisher = {Ilam University of Medical Sciences}, doi = {10.18869/acadpub.sjimu.24.6.41}, url = {http://sjimu.medilam.ac.ir/article-1-2738-en.html}, eprint = {http://sjimu.medilam.ac.ir/article-1-2738-en.pdf}, journal = {Journal of Ilam University of Medical Sciences}, issn = {1563-4728}, eissn = {2588-3135}, year = {2017} } @article{ author = {AliMohammadzadeh, khalil and Hosseini, Seyed mojtaba and Maleki, Shahnaz}, title = {Investigating the Relationship between Psychological Empowerment and Quality of Work Life with Job Burnout among Health Experts of Health Deputy Ilam Province in 2014}, abstract ={Introduction: Today, job burnout and effective variables on its reduction or increase is one of the most important issues in human resource management. The relationship between key variables of psychological empowerment and quality of work life with job burnout is effective in solving problems of human resources and promotion of organization. Materials & methods: This study is descriptive and correlational. The study population included all health experts working in the health deputy of University of Medical Sciences in 2014. According to Krejcie & Morgan’s table (1970), the sample size determined equal to 148, which were selected using stratified sampling method. The tools used in the study were the standard psychological empowerment inventory of Spreitzer (1995), Walton’s questionnaire of quality of work life (1973), Maslach’s Job Burnout (1985) and a checklist made by the author. After collecting data, SPSS 22 and descriptive statistics were used to calculate the mean and related tables. Inferential statistics such as Kolmogorov-Smirnov, Pearson correlation coefficient, linear regression and variance analysis tables were used for the analysis of data. Findings: There is a significant inverse relationship between psychological empowerment and job burnout of health experts (r=0.280). Among dimensions of empowerment only the corresponding t with β of job was significant with coefficient of -0.314 in the error level of fewer than 5%. There is also a significant inverse relationship between quality of work life and job burnout of health experts (r=-0.154) and among dimensions of quality of work life only the corresponding t with β of providing opportunity of growth with coefficient of -0.379 was significant at the error level of fewer than 5%. Discussion & conclusion: These results indicated the importance of effective interventions in the field of implementing education programs on employee empowerment and improvement of the quality of work life with an emphasize on significant dimensions of job and providing growth opportunities in order to prevent job burnout among health experts by managers and planners of this field.}, Keywords = {Psychological empowerment, Quality of work life, Job burnout, Health experts}, volume = {24}, Number = {6}, pages = {54-65}, publisher = {Ilam University of Medical Sciences}, doi = {10.18869/acadpub.sjimu.24.6.54}, url = {http://sjimu.medilam.ac.ir/article-1-2793-en.html}, eprint = {http://sjimu.medilam.ac.ir/article-1-2793-en.pdf}, journal = {Journal of Ilam University of Medical Sciences}, issn = {1563-4728}, eissn = {2588-3135}, year = {2017} } @article{ author = {Arshadi, Sajad and Banaeifar, Abdolali and Tabatabaey, Hamid and Shakibatabar, Rodabeh}, title = {The Effect of Sleep and Sleep Deprivation on Cortisol and Testosterone Responses, Anaerobic Performance Indices and Blood Lactate in Active Men}, abstract ={Introduction: The aim of this study was to investigate the effects of sleep deprivation on the responses of cortisol and testosterone, anaerobic performance indices and blood lactate in active men. For this purpose we used active healthy subjects of physical education field with an average age of 23 ± 2.25 Height 174.5 ± 1.1 and the weight of 69.5 ± 7.8. Materials & methods: sleep deprivation was a night that was applied by reading, playing chess, computer game and so on. Cortisol and testosterone were measured by Liaison kit mad in England. Performance indicies were measured using the maximum Wingate anaerobic power test and blood lactate were measured using lactometer at the time of fasting, before, immediately and after the 5 minutes of anaerobic test. Data analysis using dependent and independent t test were evaluated. Findings: The results indicated that sleep deprivation than sleep leaded to significant increase in cortisol (p=0.03) and significant decrease in testosterone (p=0.01). The results showed that sleep than sleep deprivation don’t have significant differences in the performance of anaerobic power and fatigue index (p= 0.06, 0.11, 0.21) although a slight improvement in performance parameters of anaerobic power during sleep was observed. Blood lactate concentration at the time immediately after the Wingate test in sleep phase than full and partial sleep deprivation showed a significant reduction (p=0.02). At other times of rest, before and 5 minutes after the Wingate test, no significant changes (p= 0.061, 0.053, 0.61) were observed. Discussion & conclusions: Results of this study demonstrated that sleep deprivation didn’t have significant effects on reducing the anaerobic performance and fatigue in active subjects, but concentration lactate showed significant increase after sleep deprivation and after anaerobic exercise than sleep stage. These hormonal changes may be due to stress-induced sleep deprivation and sports activities.}, Keywords = {Cortisol, Sleep deprivation, Testosterone, Fatigue, Exercise performance, lactat}, volume = {24}, Number = {6}, pages = {66-76}, publisher = {Ilam University of Medical Sciences}, doi = {10.18869/acadpub.sjimu.24.6.66}, url = {http://sjimu.medilam.ac.ir/article-1-3130-en.html}, eprint = {http://sjimu.medilam.ac.ir/article-1-3130-en.pdf}, journal = {Journal of Ilam University of Medical Sciences}, issn = {1563-4728}, eissn = {2588-3135}, year = {2017} } @article{ author = {Mokhtari, Mokhtar and khatamsaz, Saeed and rahmani, fatemeh}, title = {The Effects of Hydro- alcoholic Extract of Stachys Lavandulifolia Vahl on the Hormonal Pituitary-Gonad Axis and Testis Tissue Changes in Adult Male Rat}, abstract ={Introduction: Stachys lavandulifolia is a Plant of the lamiaceas family and have flavonoid compositions. The aim of this study is to investigate the effects of hydroalcoholic extract of stachys lavandulifolia on the hormonal Pituitary-Gonadl axis and testis tissue changes in adult male rat. Materials & methods: In this experimental study fifty adult male rats of wistar race were divided into 5 groups of ten: The control group received normal diet, shame group took distilled water and experimental groups were intra peritoneal (i.p.) injected by 50, 100, 200 mg per kg body weight extract of stachys lavandulifolia. At the end of the 30th day, blood samples and levels of FSH, LH, testosterone and dihydrotestosterone were measured. Also, from tissue sections of testis tissues were taken. The collected data were analyzed by the SPSS software using ANOVA and t-test. Findings: A significant increased concentration of LH and FSH hormones was observed in experimental groups receiving the maximum extract in compared with the control and shame groups (P<0.05). Concentration of testosterone hormone in maximum dose of extract and DHT hormone in intermediate and maximum doses of extract showed a significant decrease compared to the control and shame groups (P<0.05). Also, a histological study of the number of spermatocyte cells in seminiferous tubules of the testis of the maximum dose showed   a significant reduction compared to the control and shame groups (P<0.05). Discussion & conclusions: According to the results, stachys lavandulifolia extract reduces the amount of testosterone and DHT hormones. Apigenin in extracts will possibly impair the function of the male reproductive system.}, Keywords = {Stachys lavandulifolia vahl, Pituitary gonad, Testosterone, Dihydrotestosterone , Rat}, volume = {24}, Number = {6}, pages = {77-86}, publisher = {Ilam University of Medical Sciences}, doi = {10.18869/acadpub.sjimu.24.6.77}, url = {http://sjimu.medilam.ac.ir/article-1-2971-en.html}, eprint = {http://sjimu.medilam.ac.ir/article-1-2971-en.pdf}, journal = {Journal of Ilam University of Medical Sciences}, issn = {1563-4728}, eissn = {2588-3135}, year = {2017} } @article{ author = {Nosratabadi, Mehdi and Halvaipoor, Zohreh and GhaedAminiHarooni, Gholamrez}, title = {Predicting Suicide Ideation Based on Psycho-Social Factors and Probability of Drug Abuse in Soldiers: A structural model}, abstract ={Introduction: Military service is entry to a new environment with a particular order in which various stressors can increase the possibility of forming psycho-social harms (including suicidal ideation, depression and substance abuse). The purpose of this study was to explain the suicide ideation among soldiers based on some Psycho-Social variables. Materials and methods: In this correlation-based structural modeling study, 176 soldiers were selected using stratified random sampling. The Beck Scale for suicidal Ideation, The Beck depression Scale, Social support Scale and Possibility of substance abuse Scale were completed and analyzed by SPSS and AMOS Software. Findings: 28.4 of the studied individuals were at high risk for suicidal thoughts, there was significant and positive association between depressions, possibility of substance abuse with suicidal ideation (p<.05). Social support and familial, socio-economic status only indirectly affect suicidal ideation. The final model showed that 73% of the overall variance of suicidal ideation was attributed to these variables. Discussion & conclusions: According to results we can conclude that High-risk behaviors such as suicide result from the interaction of environmental, social, personal and family factors. Due to the increased risk of suicidal thoughts, taking serious action to promote mental and social health of soldiers is more crucial. }, Keywords = {Suicide Ideation, Substance abuse, Psycho-Social Factors, Solidiers}, volume = {24}, Number = {6}, pages = {87-96}, publisher = {Ilam University of Medical Sciences}, doi = {10.18869/acadpub.sjimu.24.6.87}, url = {http://sjimu.medilam.ac.ir/article-1-2788-en.html}, eprint = {http://sjimu.medilam.ac.ir/article-1-2788-en.pdf}, journal = {Journal of Ilam University of Medical Sciences}, issn = {1563-4728}, eissn = {2588-3135}, year = {2017} } @article{ author = {Shamsi, Morteza and Dalimi, Abdolhoseyn and Khosravi, Afra and Ghafarifard, Fatemeh and Pourahmad, Fazel}, title = {Determination and Sequencing of Genotypes of Echinococcus granulosus from Stray Dogs isolates with Cox1 Gen in Ilam, West of Iran}, abstract ={Introduction: Hydatidosisis one of the most common diseases of human and animals from Cestoda class with worldwide distribution. This disease of both public health and economic damage is very important. This parasite has a high genetic diversity and includes a complex of different genotypes .Usually in areas where disease is endemic; biologically there is a relatively high genetic diversity in parasites. Studies in different parts of the world demonstrate that genotype variation and the nature of Echinococcus granulosus influenced on the life cycle of parasite, transmission routes, pathogenesis, and antigenicity, immunogenicity, response to medication, epidemiology and control of the disease. The main aim of the present study was to investigate genotype diversity of E. granulosus which was isolated from stray dogs in Ilam city, West of Iran. Materials & methods: Adult worms were collected from the small intestine of the stray dogs. DNA was extracted from the adult worms and the partial mitochondrial DNA Cytochrome Oxidasesubunit 1 (Cox1) was amplified by PCR then the products were digested by using Alu1 and HpaII restriction enzymes. Finally, a number of PCR products were bidirectionally sequenced. Sequence and phylogenetic analyses were performed using MEGA6 (Mega software. net). Findings: Totally, twenty stray dogs out of 75 (26.66%) showed infection with E. granulosus. Amplified PCR product for all isolates was a band of approximately 450bp. Alu1 digested the product into two bands of approximately 175bp and 275bp fragments, while the HpaII cut the product into 265bp and 185bp fragments for all dog samples. Based on the DNA sequencing and PCR-RFLP results, dog samples indicated to pertain the genotypic similarities. According to the phylogenetic tree, there is at least one genotype of parasite, which belongs to E. granulosous sensu stricto (G1–G3) complex and overall isolates sequences of mtDNA indicated 100 % homology with references G1, G2, and G3 sequences in the GenBank database. Discussion & conclusions: The results of this study indicated that genotypic similarities between the sizes of DNA bands of E. granulosus from all isolates with PCR-RFLP and sequencing methods indicated the occurrence of similarities genotypes of E.granulosus in Ilam region. There is at least one genotype of parasite, which belongs to E. granulosous sensu stricto(G1-G3)complex.}, Keywords = {Echinococcus granulosus, Genotypes, PCR-RFLP, Sequencing, Ilam}, volume = {24}, Number = {6}, pages = {97-106}, publisher = {Ilam University of Medical Sciences}, doi = {10.18869/acadpub.sjimu.24.6.97}, url = {http://sjimu.medilam.ac.ir/article-1-3243-en.html}, eprint = {http://sjimu.medilam.ac.ir/article-1-3243-en.pdf}, journal = {Journal of Ilam University of Medical Sciences}, issn = {1563-4728}, eissn = {2588-3135}, year = {2017} } @article{ author = {NakhaeiMoghaddam, Mahboobeh and Najafi, Maliheh}, title = {Effect of Zinc Oxide Nanoparticles on the Pigment Production of Clinical Isolates of Pseudomonas aeruginosa}, abstract ={Introduction: Nanoparticles with the different sizes, surfaces and chemical characteristics can have different applications. Pseudomonas aeruginosa is an opportunistic bacterium that has the ability to produce pigment. The aim of this study was to investigate the effect of zinc oxide (ZnO) nanoparticles on pigment production of clinical isolates of Pseudomonas aeruginosa. Materials & methods: In this description cross-sectional study, 15 clinical isolates of Pseudomonas aeruginosa were collected from hospitals in Mashhad. Bacteria were identified using biochemical tests and polymerase chain reaction (PCR) by specific primers of exoA gene. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of zinc oxide nanoparticles (diameter of 4-7 nm) were determined by agar dilution method. Glycerol- alanine (GA) medium containing different concentrations (0, 20, 40 and 60 mg/ml) of nanoparticles were used for investigation of the effect of ZnO nanoparticles on pigment production. The pigment was extracted by adding chloroform.  Findings: All clinical isolates were identified by biochemical experiments as P. aeruginosa and exoA gene was detected in all bacteria. The average MIC and MBC of ZnO nanoparticles were 60 mg/ml and 70 mg/ml, respectively. All isolates were examined and compared for pyocyanin pigment production. The pigment production was significantly reduced with increasing concentrations the ZnO nanoparticles (p < 0.05). Discussion & Conclusion: Zinc oxide nanoparticles had inhibitory effect on bacteria and pigment production. Pigment production decreased with increasing concentrations of nanoparticles. ZnO nanoparticles could be used in prevention or helping to treat P. aeruginosa infections.}, Keywords = {Pyocyanin, Nanoparticles, Zinc oxide, Pseudomonas aeruginosa}, volume = {24}, Number = {6}, pages = {107-116}, publisher = {Ilam University of Medical Sciences}, doi = {10.18869/acadpub.sjimu.24.6.107}, url = {http://sjimu.medilam.ac.ir/article-1-3425-en.html}, eprint = {http://sjimu.medilam.ac.ir/article-1-3425-en.pdf}, journal = {Journal of Ilam University of Medical Sciences}, issn = {1563-4728}, eissn = {2588-3135}, year = {2017} } @article{ author = {HosseinpourFeizi, MohammadAli and Dastmalchi, Narges and Pouladi, Nasser and Safaralizadeh, Reza and Azarfam, Parvi}, title = {Association of FAS Gene Polymorphism(-1378G>A) with Risk of Breast Cancer in Northwestern Iran}, abstract ={Introduction: Breast-cancer is the most common cancer among women. FAS gene is crucial and important in the apoptotic pathway of cell death. Decreased expression of FAS gene and consequently de-regulation of proapoptotic signaling have been seen in various tumors such as breast-tumors. Single-nucleotide polymorphisms in the promoter of FAS gene such as G>A substitution at nucleotide position -1378 that is located within the Sp1 transcription-factor binding site, may influence FAS expression. This study investigated the association between FAS-1378G>A polymorphism and susceptibility to breast-cancer in northwestern Iran. Materials & methods: This study was conducted on 170 breast-cancer patients and 154 healthy controls. Different genotypes of FAS-1378G>A were determined using Tetra-ARMS-PCR and direct DNA-sequencing and compared. Findings: In the control-group, the genotype distribution of FAS polymorphism, showed 62.17%, 35.25%, 1.28% for GG, AG, AA genotypes, respectively. In the cancer-group, the distribution was 59.41%, 38.23% and 2.35% for GG, AG, AA genotypes, respectively. Distribution differences in the FAS-1378G>A polymorphism between the cases and controls were not statistically significant (p>0.05). Discussion & conclusions: The present investigation is the first study in regard to the association of FAS-1378G>A polymorphism with breast-cancer risk in northwestern population of Iran. The results of this study showed that there were no significant differences in the genotype/allele distribution between cases and controls. These findings suggest that FAS-1378G>A polymorphism may contribute to breast cancer susceptibility in northwestern Iran. According to the results of this study, rs2234767 polymorphism can be as a marker for lymph-node involvement and age at diagnosis in the studied population.   }, Keywords = {Polymorphism, FAS gene, Breast cancer}, volume = {24}, Number = {6}, pages = {117-126}, publisher = {Ilam University of Medical Sciences}, doi = {10.18869/acadpub.sjimu.24.6.117}, url = {http://sjimu.medilam.ac.ir/article-1-3570-en.html}, eprint = {http://sjimu.medilam.ac.ir/article-1-3570-en.pdf}, journal = {Journal of Ilam University of Medical Sciences}, issn = {1563-4728}, eissn = {2588-3135}, year = {2017} } @article{ author = {Yarnazai, Ameneh and Nouroziyeganeh, Morteza and Poursalehkachoumesghali, Adeleh and Zarei, Reza and Najafi, Mohammad and Esfandiari, Golnaz}, title = {The Study of Relationships between Some Antioxidants in Patients with Glaucoma}, abstract ={Introduction: Glaucoma is a chronic optic degenerative neuropathy in which people may lose their peripheral vision. Since various factors are involved in the pathogenesis of this disease the aim of this study was to investigate the relationships between serum and aqueous humor selenium levels, serum glutathione and hemolysate and aqueous humor glutathione peroxidase 1 values with primary open angle glaucoma. Materials & methods: In this study, 45 patients with open-angle glaucoma and 45 controls were randomly selected and diagnosed by specialists. Measurement of erythrocyte glutathione peroxidase 1 was normalized by hemoglobin. Hemoglobin and glutathione measurements were performed by colorimetric method. Serum and aqueous humor selenium values were measured using graphite furnace atomic absorption spectrophotometry and atomic absorption spectroscopy with hydride generator. Statistical analysis was performed using SPSS ver.18. Findings: Total aqueous humor antioxidant value showed no significant difference between patient and control groups (p=0.84). However, both groups showed comparable levels of aqueous humor selenium so that in patients was significantly higher than controls (p=0.02). It was also observed that serum selenium increased significantly in comparison with aqueous humor selenium (p=0.0001). It was also found that aqueous humor selenium was not correlated to intraocular pressure (p=0.045). Discussion & conclusions: It seems that selenium has an important role in biological pathways associated with pathogenesis of disease.}, Keywords = {Selenium, Glutathione peroxidase1, Antioxidants }, volume = {24}, Number = {6}, pages = {127-137}, publisher = {Ilam University of Medical Sciences}, doi = {10.18869/acadpub.sjimu.24.6.127}, url = {http://sjimu.medilam.ac.ir/article-1-3640-en.html}, eprint = {http://sjimu.medilam.ac.ir/article-1-3640-en.pdf}, journal = {Journal of Ilam University of Medical Sciences}, issn = {1563-4728}, eissn = {2588-3135}, year = {2017} } @article{ author = {Sadoghi, Seyed Damoon and Rahbariyan, Raheleh}, title = {Investigation the Effect of Glycyrrhizic Acid on Ovarian Follicle in Polycystic Ovarian Syndrome Mice Model}, abstract ={Introduction: Polycystic ovary syndrome (PCOS), as the most important reason for anovulation and is the most prevalent endocrine disorder in reproductive-aged women. Glycyrrhizic acid is the most important saponins from licorice. Considering the hypoandrogenic and antioxidant properties of licorice, the aim of this study was to evaluate the effect of glycyrrhizic acid on ovarian follicle in polycystic ovarian syndrome mice model. Materials & methods: In this experimental study 28 mice were divided into 4 equal groups. Control, PCOS control and experimental PCOS treated with glycyrrhizic acid (25 and 50 mg/kg, ip). PCOS was induced by a single intramuscular injection of estradiol valerate in PCOS control and experimental PCOS groups. Glycyrrhizic acid was intraperitoneally injected into experimental PCOS groups for 16 days. Saline solution was injected to the animals of control and PCOS control groups. At the end of injection, ovarian tissue samples were stained with Hematoxylin-Eosin and histologic changes were examined. Data were analyzed using one-way ANOVA, and Tukey statistical tests. Findings: The number of preantral follicles, antral follicles and corpus luteum in the PCOS group treated with 50 mg/kg glycyrrhizic acid compared to the PCOS control group significantly increased and the number of cystic follicles significantly decreased (p<0.05). Discussion & conclusions: Glycyrrhizic acid with protective effect on ovarian tissue is effective in improving follicular symptoms of polycystic ovarian syndrome.}, Keywords = {Polycystic ovarian syndrome, Glycyrrhizic acid, Ovarian follicles, Mice}, volume = {24}, Number = {6}, pages = {138-148}, publisher = {Ilam University of Medical Sciences}, doi = {10.18869/acadpub.sjimu.24.6.138}, url = {http://sjimu.medilam.ac.ir/article-1-3702-en.html}, eprint = {http://sjimu.medilam.ac.ir/article-1-3702-en.pdf}, journal = {Journal of Ilam University of Medical Sciences}, issn = {1563-4728}, eissn = {2588-3135}, year = {2017} } @article{ author = {Abdi, Soheil}, title = {Evaluating the Impact of Static and Alternative Electromagnetic Fields on Cardiovascular Disease Parameters}, abstract ={Introduction: Recently, investigation about the effects of magnetic fields on human cardiovascular parameters becomes a subject of a public concern and private debate. This study was conducted to evaluate the effects of static magnetic fields (SMFs) and extremely low frequency (ELF) electromagnetic fields (EMFs) on cardiovascular parameters such as LDL physicochemical modifications. Materials & methods: LDL was separated from a pooled serum of 20 male volunteers by sequential ultracentrifugation. Then effect of SMFs and EMFs on LDL modification such as LDL aggregation and surface charge of LDL was investigated. Findings: The results demonstrated that the static magnetic flux densities of 0.25 and 0.5 mT decrease, and static magnetic flux densities of 3 and 4 mT increase the zeta potential in comparison to the control. Weak ELF-EMFs of 0.125-0.5 mT cause to decrease in LDL zeta potential in a time and dose dependent manner while in moderate ELF-EMFs of 1-4 mT  LDL zeta potential was started to increase after the initial decrease at the first hour of exposure. All doses of SMF and ELF-EMF used in this research increased the LDL aggregation in a time and dose dependent manner. Discussion & conclusions: It is concluded that weak and moderate SMFs and ELF-EMFs can alternate the tendency of LDL to aggregation and this alteration is dependent on the applied magnetics flux density and time of exposure. Static and electromagnetic fields in addition to their role in producing and stability of free radicals and promoting lipid peroxidation can influence the metabolism of lipoproteins and their interaction with other molecules such as apo lipoproteins, enzymes and receptors through the alteration of the LDL zeta potential and its particles tendency to aggregation. With regard to the effects of ELF-EMFs and moderate SMFs on LDL aggregation as important modifications of LDL that involved in the promotion and progression of atherosclerosis, these magnetic fields can be considered as a risk factor in CVD and atherosclerosis.  }, Keywords = {Low density lipoprotein, Static magnetic field, Extremely low frequency electromagnetic field, LDL aggregation, LDL zeta potential}, volume = {24}, Number = {6}, pages = {149-158}, publisher = {Ilam University of Medical Sciences}, doi = {10.18869/acadpub.sjimu.24.6.149}, url = {http://sjimu.medilam.ac.ir/article-1-3682-en.html}, eprint = {http://sjimu.medilam.ac.ir/article-1-3682-en.pdf}, journal = {Journal of Ilam University of Medical Sciences}, issn = {1563-4728}, eissn = {2588-3135}, year = {2017} } @article{ author = {Bageri, Ozra and Olad, Gholam reza and Shahcheraghi, Fereshteh and Sororizanjani, Rahim}, title = {Isolation and identification of strains of Imipenem-resistant Pseudomonas aeruginosa Strains Isolated in clinical samples from 4 major hospitals of tehran, using MIC method}, abstract ={Introduction: Pseudomonas aeruginosa is a major agent of hospital infection which has a resistance intrinsic to a wide range of Antibiotics. It is resistant to beta-lactam antibiotics because of Beta-lactamase and Metalo-lactamase enzymes production. They have crucial problems in the treatment. The goal of this research is to isolate and characterize strains which are resistant to beta-lactam and Imipenem Antibiotics in clinical samples from four major hospitals in Tehran. Methods & methods:  In this study 600 samples of Pseudomonas aeruginosa were  collected  from patients and those people  referring to Baqyiatallah hospital ,  Imam Khomeini hospital , Shahid Motahari Burns Center and Pediatrics Center during two years, In the first step Antibacterial resistance were prefer by wide range of Antibiotics (Kirby-Bauar). The MIC test was used to Ceftazidime and Imipenem by Microdiution tube and  CLSI protocol. Findings: This research demonstrated that the highest sensitivity of bacteria is to Imipenem (92%) and Tetracycline (91.2%) The results showed that 6 % of the MIC of strains are resistant to imipenem (4μg/ml≤ MIC) and the 39/5 % of them are resistant to Ceftazidime (16μg/ml ≤ MIC), respectively. Discussion & conclusions: These results showed that consumption of these Antibiotics should be used precisely due to the highest resistance of these bacteria to Imipenem and third generation Cephalosporin’s otherwise it can transfer to other strains Gram-Negative bacteria special.}, Keywords = {Pseudomonas aeruginosa, Imipenem, Antimicrobial resistance, MIC}, volume = {24}, Number = {6}, pages = {159-168}, publisher = {Ilam University of Medical Sciences}, doi = {10.18869/acadpub.sjimu.24.6.159}, url = {http://sjimu.medilam.ac.ir/article-1-3150-en.html}, eprint = {http://sjimu.medilam.ac.ir/article-1-3150-en.pdf}, journal = {Journal of Ilam University of Medical Sciences}, issn = {1563-4728}, eissn = {2588-3135}, year = {2017} } @article{ author = {Akbari, Ghasem and Shahbazfar, Amirali and Kianifard, Davoud and Rezaei, Heresh and Shokrollahi, Siamak and Mohebi, Dony}, title = {Microscopic Study of the Healing Effects of the Mixture of Olive Oil and Lime Water on the Second Degree Burning in Rats}, abstract ={Introduction: Burning injuries are among physical and chemical  destructive phenomena which sometimes cause death . Anti bacterial effects of olive oil and lime water has been proved previously. Olive oil and lime water are used to treat burning injuries in Iran by traditional practitioners . The aim of this study was a microscopic survey on the healing effects of olive oil and lime water on second degree burning injuries in rat . Material & methods: In this study, 36 Wistar rats were used. After the production of a second degree burning injury, the rats were randomly divided into three groups. The first group were treated with the combination of olive oil and lime water, the second group were treated with silver sulfadiazine 1% and the third group received normal saline. Untill the end of the 4th week 3 of the rats were killed each week and tissue specimens were taken from them. Afterwards microscopic slides were made of them. The slides were studied qualitatively using a light microscope. The number of blood vessels were counted in the surface unit too. Findings: The number of blood vessels enhanced with the time. This enhancement is more in the group of olive oil and lime water. With the maturity of the wounds the number of the vessels reduced. Qualitative study showed that olive oil and lime water treat the injuries faster and vascularization, granulation tissue growth and maturity and epithelialization were faster in this group. Discussion & conclusions: Olive oil and lime water can be used as a cheap treatment for second burning injuries.}, Keywords = {Olive oil and lime water, Rat, Second degree burning, Microscopic study}, volume = {24}, Number = {6}, pages = {169-177}, publisher = {Ilam University of Medical Sciences}, doi = {10.18869/acadpub.sjimu.24.6.169}, url = {http://sjimu.medilam.ac.ir/article-1-3660-en.html}, eprint = {http://sjimu.medilam.ac.ir/article-1-3660-en.pdf}, journal = {Journal of Ilam University of Medical Sciences}, issn = {1563-4728}, eissn = {2588-3135}, year = {2017} } @article{ author = {Mohammadi, Esfandyar and Zareie, Ghodratollah}, title = {Investigating the Effect of Health Care Improvement Plan on the Payment of the Insured in Iranian Health Insurance Organization (Case Study: Hospitalized Patients in Collegiate Hospitals of Ilam City in December 2013 and 2014)}, abstract ={Introduction: The health system reform plan was carried out in university hospitals with eight practical plans in the second half of June 2014. One of these plans is the decrease in the payment made by inpatients. The present research has been conducted aiming at studying the effect of the design of changing health system pays of insurance by people. Materials & methods: The present study is analyzing- descriptive and field studies that were done in 2013-2014 in quantitative and cross sectional way.  The statistical population of this research consists of 2178 people under the insurance of health care organization of Iran that were hospitalized in the hospitals of Ilam of whom 937 belong to 2013 and 1205 belong to 2014. Out of these patients, 331 subjects have been selected by Morgan table as the research sample. In the present study the librarian method and theoretical bases were used to collect athering data and statistical findings have been selected by field method. The bases of collecting findings were statistics and documents of costs of inpatients that were analyzed by Excel and SPSS22 software in two parts of descriptive and inferential statistics. Findings: The findings show that the mean of total of costs of each inpatient in 2014 had growth compared to 2013 in 44 percent. Final share of pay of people in 2014 compared to 2013 in women and delivery part had decreased in 11.2 percent and reached 26 percent and other parts with 10.6 percent decreasing, it reached 4.6 percent that the share of rural insurance was more than other ones. During the design of changing health system, governmental subsidies covered 6.1 of hospital costs and mean of base cost of insurance with growth of 5.9 percent was 86 percent. Discussion & conclusions: According to the results of the present study, the variables of the health system reform plan, the subsidies paid by the govermment to the health care system as well as having an agraring certificate lead to a decrase in payment made by the patients. Nevertheless the implementation of the health system reform plan has had the general effects of an increase in the expenses.}, Keywords = {Health system reform plan, Decrease in the payments, Health insurance organization}, volume = {24}, Number = {6}, pages = {178-188}, publisher = {Ilam University of Medical Sciences}, doi = {10.18869/acadpub.sjimu.24.6.178}, url = {http://sjimu.medilam.ac.ir/article-1-3713-en.html}, eprint = {http://sjimu.medilam.ac.ir/article-1-3713-en.pdf}, journal = {Journal of Ilam University of Medical Sciences}, issn = {1563-4728}, eissn = {2588-3135}, year = {2017} } @article{ author = {Jafari, Asghar and Hesampoor, Fatemeh}, title = {The Comparison of Coping Strategies and Psychological Hardiness between Parents of Children with Cancer of Positive and Negative Responding to Treatment}, abstract ={Introduction: Pediatric cancer as a prevalent disease and chronic effect parents and its treatment process depend on psychological traits and empowerments of parents. So the present study aimed to compare coping strategies and psychological hardiness between parents of children with cancer of positive and negative responding to treatment. Materials & methods: Methodology was ex-post facto. Population was all between parents of children with cancer under treatment in Mahak hospital in Tehran in 2016. Subjects were parents of children with cancer (50 positive and 50 negative responding to treatment) selected by available sampling. Coping strategies and psychological hardiness of parents were measured by coping strategies (WOCQ) and Cobasa's personal views (P.V.S) questionnaires and data analyzed by test of t- student. Findings: The research findings indicated that there is a significant difference between coping strategies (focused emotion and focused problem) and psychological hardiness children's parents with cancer of positive and negative responding to treatment (P<0/01). Discussion & conclusions: The results provide some evidence to suggest that the coping strategy of focused problem and psychological hardiness of children's parents with cancer of positive responding to treatment is higher than children's parents with cancer of negative responding to treatment. In other words, the coping strategy of focused problem and psychological hardiness of parents can affect positively on treatment of children with cancer. Therefore, it is suggested that in beginning of treatment process of children with cancer, promote the coping strategy of focused problem and psychological hardiness of parents or caregivers.}, Keywords = {Coping strategies, Psychological hardiness, Children with cancer, Responding to treatment}, volume = {24}, Number = {6}, pages = {189-202}, publisher = {Ilam University of Medical Sciences}, doi = {10.18869/acadpub.sjimu.24.6.189}, url = {http://sjimu.medilam.ac.ir/article-1-3966-en.html}, eprint = {http://sjimu.medilam.ac.ir/article-1-3966-en.pdf}, journal = {Journal of Ilam University of Medical Sciences}, issn = {1563-4728}, eissn = {2588-3135}, year = {2017} } @article{ author = {Asadi, Pouyan and Alivaisi, Elahe and Norollahimoghadam, Nazani}, title = {Pharmaceutical Inhibitor Design against Cyclooxygenase2 to Reduce the Inflammation and Pain}, abstract ={Introduction: In the current study, to reduce the side effects of anti-inflammatory drugs and increase their specificity, a new pharmaceutical inhibitor was designed by computational Biology and Bioinformatics knowledge. Materials & methods: For this purpose, first, 150000 compounds with medicinal properties from ZINC database and also the files related to the structure of the enzyme cyclooxygenase2 from RCSB (Research Collaboratory for Structural Bioinformatics) were extracted. After preparing them, all of these chemical compounds were docked with the target enzyme in order to select the best pharmaceutical inhibitor (ligand). Findings: After checking the computation, 10 compounds of ligands that were the results of Docking, were selected according to the Gibbs free energy (least ΔG). Based on the results of the docking operation, inhibitor binding to cox2 causes conformational changes of enzyme, potential energy reduction, and increasing the stability of inhibitor-enzyme complex. Discussion & conclusions: According to the results obtained from the study, the inhibitors can reduce the inflammation and pain in different inflammatory diseases, by placing in the active site on the basis of more specificity and finally less toxicity.}, Keywords = {Cyclooxygenase2, Molecular docking, Nonsteroidal anti-inflammatory drug, Virtual screening, molecular dynamics}, volume = {24}, Number = {6}, pages = {203-212}, publisher = {Ilam University of Medical Sciences}, doi = {10.18869/acadpub.sjimu.24.6.203}, url = {http://sjimu.medilam.ac.ir/article-1-3336-en.html}, eprint = {http://sjimu.medilam.ac.ir/article-1-3336-en.pdf}, journal = {Journal of Ilam University of Medical Sciences}, issn = {1563-4728}, eissn = {2588-3135}, year = {2017} }