TY - JOUR JF - sjimu JO - J. Ilam Uni. Med. Sci. VL - 30 IS - 5 PY - 2022 Y1 - 2022/12/01 TI - Effect of Salix Alba Leaves Hydro-Alcoholic Extract on PTZ-Induced Seizure in Male Mice TT - اثر عصارۀ هیدروالکلی برگ بید سفید (Salix Alba) بر تشنج القاشده با پنتیلن تترازول (PTZ) در موش سوری نر N2 - Introduction: Regarding the chronic nature of epilepsy and resistance to chemical drugs, herbal medicine has received remarkable interest. This study investiagted the anticonvulsant effects of hydro-alcoholic extract of Salix Alba leaves on PTZ-induced seizure in male mice. Material & Methods: In total, 56 albino male mice weighing 20-25 g were divided randomly into seven groups (8 animals per group) including negative (saline), positive (Phenobarbital) control, and five groups which received different doses of hydro-alcoholic extract of Salix Alba leaves. After 45 min, all groups received the convulsant pentylene tetrazole, and the onset time of myoclonic, tonic-clonic seizures, and the 24-hour mortality rate were measured. (Ethic code: IR.GUMS.REC.1394.566) Findings: The extract significantly delayed the onset of myoclonic and tonic-clonic seizures at a dose of 100 mg/kg (P<0.01) and for other doses (P<0.001), compared to the control group. Moreover, the extract decreased the 24-h death. This was significant at 1000 mg/kg (P<0.001), as well as 300, 500, and 800 mg/kg (P<0.05), compared to the control group. Discussion & Conclusion: It seems that the hydro-alcoholic extract of Salix Alba leaves has a significant diminishing effect on PTZ-induced seizures in male mice which is due to its anti-inflammatory and anti-oxidant effects. SP - 32 EP - 39 AU - Khalighi Sigaroudi, Fakhri AU - Rostampour, Mohammad AU - Soltani tehrani, Bahram AD - Cellular and Molecular Research Center, Facultyof Medicine, Guilan University of Medical Sciences, Rasht, Iran KW - Mice KW - Pentylenetetrazol KW - Salix Alba leaves KW - Seizure UR - http://sjimu.medilam.ac.ir/article-1-7373-en.html ER -