@ARTICLE{Kenarkoohi, author = {Abdi, Jahangir and Shams, Morteza and Visani, Yousef and Karimiyan, Mohammad and Kenarkoohi, Azra and }, title = {Prevalence of Microsporidia in HIV-infected Patients in Iran: A Meta-Analysis and Systematic Review}, volume = {28}, number = {3}, abstract ={Introduction: Microsporidiosis is an increasing opportunistic infection in patients with HIV/AIDS. There are five species of Microsporidia, including Enterocytozoon bieneusi, Encephalitozoon hellem, Encephalitozoon cuniculi, Septata intestinalis, and Pleistophora species that have been reported in HIV-infected individuals each causes a wide range of symptoms. This meta-analysis and systematic review aimed at determining the prevalence of Microsporidia in HIV-infected patients in Iran. Materials & Methods: Databases of Magiran, Scopus, Web of Sciences, Iran Medex, SID, Pubmed, Google scholar, and Irandoc were searched to investigate the studies on "Prevalence of Microsporidia in patients with HIV/AIDS in Iran". Moreover, the meta-analysis was performed using a random-effect model, and the heterogeneity among the studies was determined using the I2 test. Findings: Based on the data obtained from the studies, out of 8 studies, 1794 patients with HIV/AIDS were investigated in Iran between 2012 and 2016. According to the results, the prevalence of Microsporidia in patients with HIV/AIDS was evaluated using the PCR technique (0.8-0.18: %95 CI, 13%). The amount of heterogeneity among the studies (P<0.001) was obtained at I2=93.3. The most common Microsporidia were Enterocytozoon bieneusi, D, M, and WL-11 genotypes. However, Encephalitozoon intestinalis, Encephalitozoon cuniculi (genotypes 1 and 2), and Encephalitozoon hellem (genotype 1A) were also isolated. Discussion & Conclusions: The present study showed that the mean prevalence of Microsporidia in patients with HIV/AIDS in Iran (13%) is close to its global mean (15%). The most common Microsporidia in HIV-infected patients is Enterocytozoon bieneusi (genotype D) which is a common genotype between humans and animals; therefore, the patients should avoid contact with animals. }, URL = {http://sjimu.medilam.ac.ir/article-1-6306-en.html}, eprint = {http://sjimu.medilam.ac.ir/article-1-6306-en.pdf}, journal = {Journal of Ilam University of Medical Sciences}, doi = {10.29252/sjimu.28.3.21}, year = {2020} }