AU - Jahani, Majid AU - Matin Homaie, Hasan AU - Farzanegi, Parvin TI - Effect of Continuous and Interval Exercise on the Necroptosis and Apoptosis of Endoplasmic Reticulum Proteins in the Heart of Diabetic Wistar Rats PT - JOURNAL ARTICLE TA - sjimu JN - sjimu VO - 28 VI - 5 IP - 5 4099 - http://sjimu.medilam.ac.ir/article-1-6366-en.html 4100 - http://sjimu.medilam.ac.ir/article-1-6366-en.pdf SO - sjimu 5 ABĀ  - Introduction: Diabetes is the most prevalent endocrine disease. Apoptosis and necroptosis play a major role in the development of diabetes-related heart diseases; however, the effects of continuous and interval exercise on apoptosis and necroptosis of the heart cells in diabetics are unclear. This study aimed to investigate the effect of different intensities of aerobic exercise on apoptosis and necroptosis of the cardiac tissue of diabetic mice. Materials & Methods: In total, 32 mature, male, and white Wistar rats (mean age of 12±2 weeks and weight of 175±15 g) were randomly divided into four groups of eight animals per group. The groups included a healthy control (C), diabetic control (D), diabetic with moderate-intensity continuous training (55 min with 26 m/min speed daily) (D+MICT), and diabetic with high-intensity interval training at the 85-90% of maximum speed (D+HIIT) (5 days/week for 8 weeks). Before the training protocol, the running speed was calculated to obtain the maximum oxygen consumption. Western blot analysis was utilized to evaluate the changes in the expression of the proteins associated with apoptosis and necroptotic death path in the diabetic heart muscle myocardium. Furthermore, the one-way analysis of variance was used to determine the differences among the study groups. A p-value less than 0.05 was considered statistically significant. Ethics code: IAU.SARI.REC.1397.8 Findings: The results indicated that type 2 Diabetes Mellitus significantly increased both apoptotic and necroptotic cell death (P=0.001). However, both continuous and interval training moderated the apoptotic cell death (P≤0.05). Nonetheless, the effect of interval training was higher than that of the continuous one. It is worth mentioning that only interval training had a significant effect on reducing the necroptosis (P≤0.05). Discussions & Conclusions: It seems that continuous and interval exercise affects apoptotic death; however, intense interval exercise is more effective in necroptotic death. CP - IRAN IN - Dept of Exercise Physiology, Faculty of Physical Education and Sports Sciences, Central Tehran Branch, Islamic Azad University, Tehran, Iran LG - eng PB - sjimu PG - 53 PT - Research YR - 2020