TY - JOUR JF - sjimu JO - J. Ilam Uni. Med. Sci. VL - 26 IS - 1 PY - 2018 Y1 - 2018/5/01 TI - Analyzing Association of the IRF-5 rs10954213 Gene Polymorphism with the Risk of IdiopathicRecurrent Pregnancy Losses in South Iranian Women TT - بررسی ارتباط پلی مورفیسم rs10954213 ژن IRF-5 با خطر بروز سقط مکرر ایدیوپاتیک در زنان جنوب ایران N2 - Introduction: Recurrent pregnancy loss (RPL) is defined as the occurrence of two or more abortion before 20th week of gestation. The etiology of RPL is unknown in 50% of cases, which defines as idiopathic RPL (IRPL). Immune-related embryo injuries play an important role in the occurrence of RPL. Interferon regulatory factor-5 (IRF-5) is a member of IRF family of transcription factor, acts as upstream regulatory element of inflammatory cytokines (IL-6, and TNF-α). The aim of the present study was to investigate the relationship between IRF-5 gene rs10954213 polymorphism in the occurrence of IRPL. Materials & Methods: In this case- control study, blood samples were collected from 176 IRPL women with a history of at least 2 miscarriages with mean age of 34.2±10.9 years as the patient group, and 173 healthy postmenopausal women with at least two live births, and without a history of previous miscarriage (mean age±SD; 56.5±7.7 years) as the control group. Genotyping was performed using T-ARMS PCR. The data were analyzed using SPSS v.16 software. Findings: The frequency of G allele was lower in cases compared to control subjects. This difference was statistically significant and supported the protective effect of this allele against miscarriage (OR: 0.7, 95%CI: 0.5-0.9, p=0.04). The frequency of G carriage genotypes (GG+GA vs. AA) in women with IRPL was lower compared to the women of the control group and showed the protective role of this allele (OR:0.45, 95%CI:0.22-0.91, p-0.02). Discussion & Conclusions: Regarding the results of the present study, the rs10954213G allele of the IRF-5 gene demonstrated a protective marker against idiopathic recurrent pregnancy losses in Iranian women. SP - 94 EP - 102 AU - Amiri Jahromi, Rakhshan AU - Nasiri, Mahboobeh AD - Dept of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran KW - idiopathic recurrent pregnancy loss KW - polymorphism KW - IRF-5 gene KW - south Iranian women UR - http://sjimu.medilam.ac.ir/article-1-3747-en.html DO - 10.29252/sjimu.26.1.94 ER -