TY - JOUR T1 - Impacts of Treatment Management Methods onControl of Toxicity And Side Effects of Chemotherapy Regimens in Breast Cancer TT - تاثیر راهکارهای مدیریت درمان بر کاهش سمیت و عوارض داروهای شیمی درمانی در مبتلایان به سرطان پستان JF - sjimu JO - sjimu VL - 20 IS - 1 UR - http://sjimu.medilam.ac.ir/article-1-623-en.html Y1 - 2012 SP - 42 EP - 50 KW - toxicity-adjuvant therapy KW - breast cancer KW - side effects N2 - Introduction: Specific effects of chemo-therapy regimens and their side-effects considerably influence on patients lives and their desires of accepting or rejecting therapies. It is obvious that the patient`s idea about the effectiveness of therapy process and accepting the treatment by the patient can facilitate the recovery process greatly. In this study, the side effects and toxicity of Docetaxel-Adriamicine-Cycl-ophosphamide (TAC) and Adriamicine-Cyclophosphamide- 5 FU (FAC) as two chemotherapy regimens were investigated. Materials & Methods: This investigation was done on a cohort of 100 patients suffering from breast cancer with node- positive being treated with TAC or FAC as a double blind study. Data was gathered by completing special check-lists as interviews at the last session of chemotherapy and surveying the patients` medical records. Data was analyzed by relevant statistical tests such as Independent T-test. Findings: The results showed that in most the aspects such as amenorrhea, anemia, febrile neutropenia, hyper pigmentation and nail disorder, neurologic toxicity, convul-sion, nomeness and edema, the average mean was higher in TAC arm statistically significant. Discussion & Conclusion: Applying treat-ment managing approaches tend more to emphasize on patient’s education and im-proving their knowledge before starting chemotherapy cycle, convening of compul-sory consult meetings with expert psychiat-rists and psychologists and establishing su-pportive groups by patients who have recovered from cancer can lead to better and more conscious encountering for such patients and help them accept the therapy more conveniently. M3 ER -