TY - JOUR T1 - The Evaluation of Ethanol Effects on Fibroblast Cells Viability TT - بررسی تاثیر اتانل بر بقای سلول‌ های فیبروبلاست انسانی JF - sjimu JO - sjimu VL - 21 IS - 2 UR - http://sjimu.medilam.ac.ir/article-1-1129-en.html Y1 - 2013 SP - 170 EP - 176 KW - ethanol KW - fibroblast KW - MTT assay KW - morphologic studies N2 - Introduction: Ethanol known as ethyl alc-ohol is a volatile, flammable, colorless liq-uid. It is primarily known as the type of alcohol found in alcoholic beverages. Its consumption is very high around the world. It has been reported that ethanol intake is associated with different diseases. There-fore, here in this study the effect of ethanol on human fibroblast cells was investigated. Materials & Methods: We have carried out cell survival and morphologic studies via Invert Microscope and MTT assay methods to evaluate survival rate and morphological alterations of human fibroblast cells treated with different concentrations of alcohol. Findings: Our findings suggested that etha-nol could possibly change human fibroblast cells morphology and survival rate after 48 h incubation. In addition to this, examining fibroblast cells after 48 h culturing without ethanol showed the maintenance of these changes in next generation of the cells. Discussion & Conclusion: It can be conclu-ded that ethanol can possibly cause genetic alterations of the human fibroblast cells, so karyotype evaluations is required to deter-mine these consequences. M3 ER -