TY - JOUR T1 - The protective effects of zinc on malathion-induced acute oxidative injury in ‎‎blood rats ‎ TT - بررسی اثر حفاظتی روی بر بیومارکرهای آسیب اکسیداتیو در تماس حاد با مالاتیون درموش ‏صحرایی نر ‏ JF - sjimu JO - sjimu VL - 22 IS - 4 UR - http://sjimu.medilam.ac.ir/article-1-1344-en.html Y1 - 2014 SP - 147 EP - 152 KW - Malathion KW - Zinc KW - Oxidative stress KW - Rat N2 - The protective effects of zinc on malathion-induced acute oxidative injury in ‎male rats ‎ Abstract Introduction: Malathion is one of the most toxic organophosphorus insecticides (OPIs). OPIs may induce oxidative stress in various tissues leading to generation of free radicals and alteration in antioxidant system. The objective of this study was to investigate the possible protective effects of Antioxidant effects of zinc were evaluated against malathion-induced oxidative damage in male rat. Materials & Methods: Rats received malathion (250 mg /kg/day, IP) and zinc (5 mg/kg/day, IP) in combination or alone. 20 male rats were equally divided in to 4 groups (5 rats each). Group I (control), while Group II was given malathion. Animals of Groups III received only zinc. Group IV was given zinc+ malathion once for acute test. After treatment, blood was isolated. Cholinestrase activity (ChE) and oxidative stress marker such as total thiol groups (TTG) and total antioxidant capacity (TAC) concentration were measured. Results: Malathion reduced activity of ChE enzyme, TTG and TAC in blood. The changes in TTG and TAC, were restored by zinc. Conclusion:d. It is concluded that oxidative damage is the mechanism of toxicity of malathion that can be recovered by zinc. M3 ER -