TY - JOUR JF - sjimu JO - J. Ilam Uni. Med. Sci. VL - 14 IS - 4 PY - 2007 Y1 - 2007/1/01 TI - The Effect of Intravenous Lidocaine Premedication and Slow Rate of Fentanyl Administration on Fentanyl – Induced Coughing TT - تأثیر پیش داروی لیدوکائین وریدی و تزریق آهسته فنتانیل بر سرفه ناشی از فنتانیل در بیهوشی N2 - Abstract Introduction: Intravenous (IV) administration of Fentanyl bolus elicits cough in more than one – third of the patients. Coughs may sometimes be explosive leading to hypoxia, vomiting, with increases in intracranial, intraocular and intraabdominal pressures. Materials & Methods: This double blind clinical trial included 360 patients below 60 years with ASA status I & II, who were scheduled for elective surgeries. They were randomized into 3 groups of 120. Group I received Normal Saline as placebo, 60 secounds late fentanyl was administred slowly over a period of 30 secounds. Group II was given fentanyl over 5 secounds, 1 minute after Lidocaine, (1.5 mg/kg IV). Group III also received Normal Salin, 60 secounds before the Fentanyl was given in 5 secounds. Fentanyl dose was 2 µg/kg. Then, incidence and severity of cough was recorded, and the results were analyzed using Chi square test. P.value of 0.05 was considered significant. Results: The incidence of cough was 2.5% in group I, 9.2% and 22.5% in groups II & III respectively. The finds showed that the incidence of cough was significantly higher in group III (P SP - 31 EP - 35 AD - KW - : Fentanyl KW - Cough KW - Lidocaine KW - Injection time UR - http://sjimu.medilam.ac.ir/article-1-55-en.html ER -