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Showing 3 results for Dexamethasone

N Manuchehrian, M Arjomandi, M,h Bakhshaeu, P Hajian, N Alipur, A Farhanchi,
Volume 19, Issue 4 (1-2012)
Abstract

Abstract Introduction: Post dural puncture headache (PDPH) is an important complication of spinal anesthesia, especially in young parturient women after cesarean section. The usage of glucocorticoids such as dexamethasone is a drug suggested to treat PDPH. The aim of this study was to determine the effect, of intravenous dexamethasone in prevention of PDPH after spinal anesthesia in cesarean section. Materials & Methods: This is a doubleblind randomized clinical trial in which 246 cases of parturients candidated for cesarean section. Patients were divided randomly in 6 equal groups(n=41) according to the number of punctures (1, 2 or > 2 punctures) and administration of 8 mg intravenous dexamethasone. All the patients received spinal anesthesia using 75 mg of 5% lidocaine with a 25G quincke needle. Then, thepatientqs age,history of surgery,previous spinal anesthesia and headache,new onset and duration of PDPH and vital signes of patients were recorded. Finally the obtained data were analyzied by SPSS software. Findings: 44(17.9%) patients out of the 246 ones were affected by headache. 12.2% of patients who had received dexamethasone and 23.6% of patients who had not received it suffered from headache,(p-v= 0.030)/ The frequency of hypotension during surgery in patients who had received dexamethasone and those who had not received it were 63.4% and 76.4%, respectedly, (P-v=0.037). Discussion & Conclusion: Administration of intravenous prophylactic dexamethasone caused a significantly decrease in the incidence of PDPH & intraoperative hypotension.So, we suggest the use of 8mg intravenous dexamethasone in susceptive patients for prevention of PDPH.
Majid Ahmadi, Mahfouz Ghaderi, Syvan Khoshnam, Mohammad S Karami, Dalir Aparviz, Azad Rezazadeh, Parviz Veispanah,
Volume 23, Issue 4 (10-2015)
Abstract

Introduction: Studies have shown that pain, nausea and vomiting after abdominoplasty are the most common complications that lead to accumulation of hematoma, delay in discharge and more postoperative drug usage. Researchers use numerous medications, including corticosteroids to reduce these complications to the minimum possible extent. The present study aims at investigating the effects of intravenous Dexamethasone on post abdominoplasty pain, nausea and vomiting.
Materials & methods: This controlled clinical study was conducted on 44 patients who were candidates for abdominoplasty surgery. Patients were randomly divided into two groups, namely intervention and control ones. The intervention group received 8 mg intravenous Dexamethasone and the control group received nothing. The patients underwent identical anesthesia and surgery. After every 6 hours, pain and nausea were assessed by pain measurement scale and vomiting was analyzed through a questionnaire for 24 hours. Finally, the data were analyzed by repeated measures ANOVA test and proportion test was used to compare qualitative variables. Findings: the average of postoperative pain and nausea immediately after the surgery, after 6, 12, 18, 24 hours were significantly different in the intervention group than in the control one (P=0.03). However, there was no vomiting in both of the groups.
 Discussion & Conclusion: the results of the study indicated that Dexamethasone can reduce the postoperative pain and nausea after abdominoplasty surgery. However, due to the absence of vomiting in the two groups, there were no clear effects on vomiting.


Mohammad Bagher Ghayour, Arash Abdolmaleki, Morteza Behnamrasouli , Ali Moghimi, Naser Mahdavishahri,
Volume 26, Issue 4 (11-2018)
Abstract

Introduction: Peripheral nervous system has an innate regenerative ability, and in severe injuries leading to nerve destruction, repair does not occur spontaneously and medical intervention is required. In this regard, dexamethasone is one of useful drugs prescribed for neurological recovery after spinal cord injury. The objective of the present study was to assess the effect of dexamethasone on functional recovery and histological changes following sciatic nerve transect and regeneration with the acellular scaffolds in male Wistar rats.
 
Materials & Methods: Fifty male Wistar rats were randomly divided into five groups of 10. The groups included: negative control group(left sciatic nerve was transecte), sham-operated group) surgical procedure without the nerve transect ), and experimental groups 1 and 2 (sciatic nerve was transected and regenerated with acellular nerve scaffold) treated with 1 and 2 mg/kg of dexamethasone, respectively. Experimental group 3 (sciatic nerve was transected and regenerated with acellular nerve scaffold) was injected with vehicle. Then, 1 cm of left sciatic nerve was exposed and replaced with a piece of scaffold. Behavioral, electrophysiological, and morphological alterations were evaluated during the experiment.
 
Findings: with dexamethasone in comparison with the control group (P < 0.05). Analysis of gastrocnemius muscle mass in groups treated with dexamethasone in comparison with negative control group showed that muscle atrophy was reduced; also the dexamethasone-treated group presented significantly greater nerve fiber, axon diameter, and myelin sheath thickness (P < 0.05).
 
Discussion & Conclusions: The results showed that the administration of dexamethasone after sciatic nerve transects and grafting the acellular scaffold increased motor function in a rat animal model.



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مجله دانشگاه علوم پزشکی ایلام Journal of Ilam University of Medical Sciences
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