:: Volume 20, Issue 5 (3-2013) ::
Journal of Ilam University of Medical Sciences 2013, 20(5): 149-157 Back to browse issues page
Synthesis of antimicrobial peptides in bacteria
M Hamidi, S d Mosavi nasab *, N Ahmadi, Gh Basati, Gh r Avlad, M Zargar
Abstract:   (18075 Views)
Antimicrobial peptides -AMP- are diverse group of antimicrobial compounds, which are due to the emergence of pathogenic bacteria resistant to common antibiotics, are of great interest. These molecules like proteins often contain amino acids that are modified by deformation and the polypeptides made by ribosomes are not found. These compounds include both bacteriocin and peptide antibiotics, which are classified based on their mechanism of biosynthesis. Bacteriocins are synthesized by ribosomes and active against bacteria are closely related. Antimicrobial peptides are not synthesized by ribosomes and synthesized during the reaction compression stage with a non-ribosomal peptide complex large (NRPS). The main obstacle to the use of AMP as antibiotics is the lysis of eukaryotic cells. As they apply to pharmaceutical agents must also have a high antimicrobial activity, have low hemolytic activity. Other obstacles such as other toxicity, high cost of production, poor bioavailability and so on should also be considered. Multiple host systems -vector to produce AMP using recombinant DNA technology has been used that the E.coli had the highest use. Thus, there is great potential in the field of antimicrobial peptides and further research in this area can lead to excellent results that have significant effects on food and medicine
Keywords: peptide, antimicrobial, bacteria
Full-Text [PDF 285 kb]   (18624 Downloads)    
Type of Study: Research | Subject: Medical microbiology
Received: 2013/03/17 | Accepted: 2013/10/15 | Published: 2013/10/15

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Volume 20, Issue 5 (3-2013) Back to browse issues page